KINE-292 Chapter 12 – Flashcards
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            Cancer:
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        Abnormal, uncontrolled multiplication of cells, which, if left untreated, can ultimately cause death
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            Cancer is responsible for __ out of every 4 deaths each year.
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        1 out of 4
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            The second leading cause of death after CVD is?
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        Cancer
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            How many people die a day from cancer?
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        1600
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            What percentage of cancer deaths are related to tobacco use?
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        29%
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            Tumor:
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        A mass of tissue that serves no physiological purpose; also called a neoplasm.
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            Benign Tumor:
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        A non-cancerous tumor (like a wart).
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            Benign Tumor (Detailed):
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        1. Made of cells similar to normal surrounding cells 2. Covered by a membrane that prevents them from penetrating neighboring tissues. 3. They are dangerous only if their physical presence interfere body function (compression of artery in brain).
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            Malignant tumor:
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        A cancerous tumor, capable of invading in neighboring tissue (blood vessel, lymphatic system, nerves) as well as can travel to distant body organ.
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            Every cancer starts with the change in:
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        cell division control mechanism.
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            Metastasis:
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        Spread of cancer cells from one part of the body to another
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            Metastasis (Detailed:)
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        1. Occurs because cancer cells do not stick to each other as strongly as normal cells. They can invade near by tissue or can travel to distant organs, and multiply there to form new colonies. 2. This new tumor is called as metastases or secondary tumor. 3. To control the cancer, every single cancerous cell must be removed
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            The 5 Major Causes of Cancer:
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        1. The role of DNA 2. Tobacco use 3. Dietary factors 4. Obesity and inactivity 5. Carcinogens in the environment
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            Oncogene:
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        A gene that has mutation, and is involved in transformation of a normal cell into a cancer cell. E.g. Mutation of a tumor suppressor gene.
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            Cancer Promoters:
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        They don't cause mutation but promote cancer by accelerating the growth of cells, which means less time for a cell to repair DNA damage caused by other factors. E.g. Estrogen.
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            Smoking is responsible for up to ____ of lung cancer deaths and for about ____ of all cancer deaths.
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        90% and 29%
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            Overall tobacco use is responsible for nearly ____ premature deaths each year.
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        480,000
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            Phytochemical:
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        Naturally occurring substance found in plant foods that may help prevent chronic diseases such as cancer and heart disease
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            ____ millions American diagnosed with cancer every year, and more than ____ die
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        1. 1.6 Million 2. 580,000
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            ACS estimates that ____ cases of skin cancer can be prevented by protecting skin from sun rays.
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        90%
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            ____ of lung cancer could be prevented by avoiding the exposure to tobacco smoke.
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        87%
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            9 Types of Common Cancers:
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        1. Lung cancer 2. Colon and rectal cancer 3. Breast cancer 4. Prostate cancer 5. Cancer of female reproductive tract  6. Skin cancer 7. Head and Neck cancer 8. Testicular cancer 9. Others cancers
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            Lung cancer is the most common cause of cancer deaths in the U.S. and is responsible for ___ deaths a year.
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        158,000
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            Smokers are at risk for lung cancer by:
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        10 times or more.
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            Second hand smoke causes ____ lung cancer deaths a year.
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        7,000
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            Only ____ of lung cancer patients are alive ____ after diagnosis.
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        15% 5 years
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            Third most common type of cancer in both men and women is?
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        Colon and Rectal Cancer
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            The biggest risk factor for Colon and Rectal Cancer is?
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        Age  90% of cases are diagnosed in people age 50 or older.
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            What increases the risk for Colon and Rectal cancer?
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        red meat, smoked meat and fish, excessive smoking and alcohol
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            ACS recommends regular yearly screening for Colon and Rectal cancer after the age of ___
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        50 yrs old
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            The 5 year survival rate of Colon and Rectal cancer is ____ if detected early.
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        90%
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            The second most deaths due to cancer is?
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        Breast Cancer
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            ____ in 8 women suffer from breast cancer and ____ in 30 die from the disease.
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        1 and 1
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            The biggest factor for breast cancer is
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        genetic factor
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            If a woman has 2 close relatives with breast cancer she is at ____ risk of developing the disease.
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        4 times
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            Other risk factors for breast cancer:
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        1. Early-onset menstruation, or late-onset menopause 2. Having no children or having a first child after age 30  3. Hormone replacement therapy 4. Being obese 5. Alcohol: 6. Smoking
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            Female hormone estrogen may be common element in some risk factors
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        Estrogen promotes cell growth in responsive tissues (breast, uterus). So any factor that increases estrogen exposure may raise the risk of breast cancer.
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            ACS recommends annual mammogram at age of ____ and at age _____, every other year.
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        Age 45 and Age 55
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            Biopsy:
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        Removal and examination of small piece of body tissue for purpose of diagnosis
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            Ultrasonography:
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        An imaging method in which inaudible high- pitched sound (ultrasound) is bounced off body structures to create an image on a monitor
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            Lumpectomy:
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        removal of lump and surrounding tissue
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            Mastectomy:
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        removal of breast
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            If discovered early before it has spread, patients have about ____ chance of surviving more than 5 years,
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        98%
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            Overall rate of breast cancer survival is
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        90%
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            The most common cancer in men is ____ and is the second leading cause of cancer death in men.
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        Prostate cancer
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            Prostate cancer has nearly ____ new cases a year and ____ deaths.
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        259,000 new cases 30,000 deaths
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            The strongest predictor in Prostate cancer is
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        age
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            ____ of cases occurring in men over the age ____ and ____ above ____.
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        97% of cases over the age of 50 56% above 65 yrs old
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            ACS Recommends both PSA (Prostate-specific antigen) and rectal examination yearly after the age of ____
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        50 yrs old
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            5 year survival rate for prostate cancer is nearly
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        100%
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            Cervical cancer frequently occurs in women in their ____ and ____
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        20's and 30's
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            ____ New cases and ____ deaths a year from cervical cancer
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        13,000 new cases 4,000 deaths
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            Pap test:
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        Scraping of cells from cervix for examination to detect cancer.
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            Cervical dysplasia:
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        cells are abnormal but not cancerous
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            Uterine or Endometrial Cancer:
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        Cancer of the lining of the uterus most often occurs after age 55
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            ____ New cases and ____ deaths every year due to Uterine or Endometrial Cancer.
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        55,000 New cases 10,000 deaths
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            ____ Cancer is the most common cancer when all highly curable forms are included in the count.
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        skin
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            ____ Cases every year and ____ are of the most serious type Melanoma.
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        2.2 million 74,000 Melanoma
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            Risk for skin cancer ____ in people who have had 5 or more sun burns in the their life time.
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        doubles
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            Basal cell carcinomas
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        Deepest layer of skin
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            Squamous cell carcinomas
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        Surface layer of skin
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            95% of skin cancers happen in?
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        Basal cell carcinomas (deepest layer) and squamous cell carcinomas (surface layer)
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            Melanoma:
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        A malignant tumor of the skin that arises from pigmented cells, usually a mole.
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            Melanoma most common on which sites of the body?
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        Back, chest, abdomen, and lower legs.
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            5 year survival rate of skin cancer is ____ if tumor is localized and ____ if spread to adjacent lymph nodes.
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        98% 63%
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            Head and Neck Cancers:
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        Cancers of the oral cavity, pharynx, larynx, and nasal cavity
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            Head and neck cancers are ____ as often in men as in women.
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        twice
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            5 year survival rate for head and neck cancers is ____
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        66%
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            ____ Cancer is most common cancer among men ages ____ to ___ but is rare overall.
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        Testicular Cancer 20 to 35
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            5 year survival rate for testicular cancer is ___
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        97%
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            Pancreatic cancer kills ____ Americans every year
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        49,000
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            Bladder cancer has ____ new cases and ____ deaths every year.
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        75,000 new cases and 16,000 deaths
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            ____ bladder cancer is curable if detected early.
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        96%
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            Kidney cancer has ____ new cases and ____ deaths each year.
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        62,000 new cases and  14,000 deaths
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            Brain cancer has ____ new cases and _____ deaths each year
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        23,000 new cases and  15,000 deaths
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            Leukemia:
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        1. Cancer of the white blood cells. 2. Starts in bone marrow but can spread to lymph nodes, spleen, liver, other organs, and the central nervous system.
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            Lukemia has ____ new cases and ____ deaths each year.
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        54,000 new cases and  24,000 deaths
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            There are how many stages of Cancer?
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        5 Stages 0, I, II, III, and IV
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            Cancer stage 0:
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        not cancer but can become cancer limited to original layer of cells in which they developed.
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            Cancer Stage I, II, and III:
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        larger, cancer form, spread beyond the organ where it developed (Adjacent tissue). Higher number indicates more extensive.
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            Cancer Stage IV:
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        spread to distant tissue or organ.
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            Treatments of Cancer:
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        1. Surgery( partial or complete removal). For most cancers, surgery most useful treatment 2. Chemotherapy(destroy fast growing cells), many work on DNA replication. 3. Radiations(X-ray or gamma rays; killing tumor cell)