Itopride hydrochloride C20H27ClN2O4 structure

Flashcard maker : Lily Taylor

C20H27ClN2O4 structure
Molecular Formula C20H27ClN2O4
Average mass 394.892 Da
Boiling Point
Flash Point
Molar Refractivity
Surface Tension
Molar Volume
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Experimental Physico-chemical Properties
    • Experimental Melting Point:

      191 Ā°C LKT Labs
      194 Ā°C Biosynth Q-201260
      194-1950 Ā°C LabNetwork LN01303528
    • Experimental Flash Point:

      262.3 Ā°C Biosynth Q-201260
    • Experimental Gravity:

      262.3 g/mL Biosynth Q-201260
    • Experimental Solubility:

      DMSO:52mg/mL MedChem Express HY-B0732
      Soluble in water or methanol. Sparingly soluble in acetic acid. LKT Labs
  • Miscellaneous
    • Safety:

      P261; P262 Biosynth Q-201260
    • Target Organs:

      AChR antagonist;Dopamine Receptor antagonist TargetMol T1552
    • Bio Activity:

      AChE MedChem Express HY-B0732
      Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor. MedChem Express
      Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.; Target: AChE; Itopride is a gastroprokinetic benzamide derivative. MedChem Express HY-B0732
      Itopride hydrochloride is an AChE inhibitor (acetylcholinesterase) and D2DR inhibitor.;Target: AChE;Itopride is a gastroprokinetic benzamide derivative. The IC50 of itopride with AChE (2.04 +/- 0.27 microM) was, however, 100-fold less than that with BuChE, whereas in the case of neostigmine with AChE (11.3 +/- 3.4 nM), it was 10-fold less. The inhibitory effect of itopride on cholinesterase (ChE) activity in guinea pig gastrointestine was much weaker than that on pure AChE. the IC50s of itopride against ChE activities were found to be about 0.5 microM. The IC50 of itopride for electric eel and guinea pig gastrointestinal AChE inhibition was 200 times and 50 times as large as that of neostigmine, respectively [1]. MedChem Express HY-B0732
      Musciarinic AChR;Dopamine receptor TargetMol T1552
      Neuronal Signaling MedChem Express HY-B0732
      Neuronal Signaling; MedChem Express HY-B0732
      Neuroscience TargetMol T1552

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

No predicted properties have been calculated for this compound.

Boiling Point:
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Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
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#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

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