Hot Zone part 2 – Flashcards
Flashcard maker : Tilly Wilkinson
Reston, Virginia
10 miles west of Washington D.C.; can see Washington Monument; first planned suburbs in America; symbol of American belief
Hazleton Research Products
Division of Corning, Inc that has the Monkey house
Corning’s Hazleton unit
involved with the importation and sale of laboratory animals
Hazleton monkey house
The Reston Primate Quarantine Unit
Dan Dalgard
Doctor of veterinary medicine at the Reston Primate Quarantine Unit; Took care of the monkeys if they became sick or needed medical attention; shy and calm
Hazelton Washington
company whose headquarters are on Leesburg Pike in Vienna, Virginia
Ferlite Farms
wholesale facility located not far from the city of Manila in the Philippines; Where Hazleton Research Products accepted the shipment of monkeys from
Mindanao
Philippines where the crab-eating monkeys really originated from
Crab-eating monkyes
lives along rivers and in mangrove swamps in Southeast Asia; common lab animals because they are cheap and easily obtained; whitish fur on chest and cream-colored fur on back
Macaque
type of crab eater; long-tailed; protrusive, doglike snout with flaring nostrils and sharp canine teeth; do not like humans; love vegetables and steal them from crops
The troop
Name of the crab monkey hierarchy; led by dominant male who maintains control by staring and will kill a human who does so
John Jaax
shot many times in a violent killing
Reed Buente
police officer who took the case of John Jaax at Kansas City Homicide
John Weaver
John Jaax’s business partner; died of heart attack; possibly murdered John
Tom Geisbert
intern who discovered and took the first image of the bacteria inside the monkeys; compared what he saw to peter cardinal’s liver cells
Peter Jahrling and Tom Geisbert
whiffed flask with monkey virus
Slammer
level 4 biocontainment hospital; air locks and double steel doors, tended by nurses and doctors wearing space suits
Peter Jahrling
took his own blood and Geisbert’s to level 4 hot lab and compared them with pieces of liver from Monkey 053
Bill Volt
Dissected at least 50 infected monkeys
Hott Zone AA-4
Jahrling’s office where he fiddled with the flasks of virus culture from the monkey house
Musoke
Person’s blood used to test Marburg
Boniface
Person’s blood to test for Ebola Sudan
Mayinga
Person’s blood to test for Ebola Zaire
Glowing
The way to determine weather the virus was Ebola Zaire/Sudan or Marburg
Centers for Disease Control (C.D.C)
given mandate by congress to control human disease
Frederick A. Murphy
ne of the original discoverers of Ebola virus; wizard with electron microscope; first photographed Ebola virus; work hung in art museums
C.J. Peters
Leader of Army mission against new virus
16,000
number of wild monkeys imported to the US from tropic regions each year
Bill Volt
colony manager at Reston monkey house
Room F
Room at Reston Monkey House that contained only crab-eating monkeys from the October shipment from Ferlite Farms in the Philippines
“chronology of events”
Dalgard’s diary of what he saw inside the monkeys
Just what Dalgard saw in the monkeys
swollen spleen; enlarged kidneys; hemorrhage in organs; anorexia; lethargy; nasal discharge; bloody nose
splenomegaly
swollen spleen
epistaxis
bloody nose
spleen
filters blood and plays role in immune system; normal one is like a jelly doughnut: soft sack with a a drippy red center
infected monkey spleen
solid blood clot the size of a tangerine
Peter Jahrling
civilian virologist; reputation for knowing something about monkey viruses; thought monkeys had Simian hemorrhagic fever (SHF); hunted for viruses in fain forest
What pissed Jahrling off about shipped Monkey 053 spleen
meat was wrapped in aluminum foil like pieces of leftover hot dog and leaked over the ice
way to identify a virus
make it grow inside living cells in a flask of water, drop sample of virus on the flask and it will spread through the cells. If virus likes the cells, it will multiply
Joan Rhoderick
civilian technician
Growing up a virus
A lot like making beer….you follow the recipe and you keep the brew nice and warm until something happens
Thomas Geisbert
photographed the cardinal strain that looked like a tangled mass of 6s, Us, gs, Ys, snakes, and Cheerios missed up with patly liquefied human flesh
Joan Rhoderick
technician who had started the Reston culture; examined flask contained cells that had been infected with the simian-fever virus that came form Monkey 052; Saw a complicated world in the flask; looked like fried eggs, sunny-side up
“the cells were off the plastic”
the cells were exploded and dead… they detached from the surface of the flask and floated away in the broth
Jahrling
guessed flask had been contaminated and wiped out by pseudomonas
pseudomonas
common soil bacterium; smells like Welch’s grape juice
“put it in the beam”
to look in the electron microscope
electron microscope
more powerful than a light microscope and can see deeper into the universe within
incubation period of a filovirus
3-18 days
Jaime Jaax
12 years old
Jason Jaax
13 years old
Curtis Dunn
Nancy’s father; dying of cancer
Ada
Jerry’s mother; widow living on a ranch
Dalgard
sacrificed all the monkeys in room F in case of possible infection
Dalgard
Believed monkeys had SHF
Room H
Over thanksgiving, 5 monkeys randomly died in this room
diamond knife
metal object about an inch long; costs about $4,000; diamond edge; sharpest cutting edge of any tool on earth; sharp enough to split a virus cleanly in half;
Tom Geisbert
used his diamond knife to slice the virus and found it was a filovirus… feared it was Marburg; virus resembled Peter Cardinal’s liver cells
“chips” or “inclusion bodies”
resembled chocolate-chip cookie that was mostly chocolate chips; crystal-like blocks of pure virus
crystalloids
bricks
growth of the virus
virus grows in cell..crystalloids appear at center..move outward, toward the surface of cell..breaks apart into hundreds of individual viruses…viruses that are shaped like threads that grow out of the cell like grass….bricks distort cell and bulge it…cell bursts and dies…threads leave into bloodstream and multiply to take over more cells…process repeats
cell swells
what happens when cells are ready to burst
Colonel Clarence James Peter
military chain of command; chief of disease-assessment division of the institute; Texas drawl; spent years hunting hot agents in Central and South America; wore jeans and Hawaiian shirts; used excuse of athletes foot for lack of uniform
dangerous unknowns
“The interesting stuff” Colonel Clarence James Peters called
“a major pucker factor”
military slang term that refers to a certain tightening sensation in the nether regions of the body in response to fear
ebola
species jumper
2 options to contain biocontainment
1. seal off monkey colony and watch them die 2. sterilize whole place