Globular Proteins – Flashcards

Unlock all answers in this set

Unlock answers
question
What is the difference between globular proteins and fibrous proteins?
answer
globular- spherical shape; fibrous- long, thin fibers
question
What are some examples of globular proteins?
answer
insulin, hemoglobin, enzymes, antibodies
question
What are examples of fibrous proteins?
answer
skin, hair, nails, wool
question
What are the oxygen binding proteins?
answer
Myoglobin, Hemoglobin, Cytochromes
question
What transports oxygen from the lungs to various tissues?
answer
hemoglobin
question
Oxygen gets dumped to ___________ because of its __________ affinity for oxygen.
answer
myoglobin; higher
question
Myoglobin has a lesser/higher affinity for oxygen than hemoglobin?
answer
higher
question
The oxygen binding curve for hemoglobin is:
answer
sigmoidal
question
The oxygen binding curve for myoglobin is:
answer
hyperbolic
question
oxygen carriers are ___________ proteins.
answer
globular
question
How many polypeptide chains make up hemoglobin (tetramer)?
answer
four
question
One heme molecule of hemoglobin binds ____ oxygen molecules.
answer
4
question
Taut is low/high affinity?
answer
low
question
Relaxed is low/high affinity?
answer
high
question
Hemoglobin changes from ______ to ______ when it binds with O2.
answer
taut; relaxed
question
What are the different forms of hemoglobin?
answer
oxyhemoglobin, deoxyhemoglobin, methemoglobin
question
hemoglobin plus O2; relaxed (R ) state, more stable (higher affinity for oxygen; more stable than T when oxygen is bound)
answer
oxyhemoglobin
question
has a vacant O2 binding site; tense (T) state (low affinity state; more stable than R when no oxygen bound)
answer
deoxyhemoglobin
question
iron in the oxidized state (Fe+3) plus hemoglobin (Fe+3 can’t bind oxygen)
answer
methemoglobin
question
___ and ___ : have higher affinity for heme (Fe+2) than oxygen; can displace oxygen from Hb
answer
CO; NO
question
What percent of hemoglobin is HbA?
answer
95%
question
What percent of hemoglobin is HbA2?
answer
4%
question
What form of hemoglobin is HbF?
answer
1%
question
Where is HbF usually found?
answer
fetus during 2nd and 3rd trimester
question
HbF-Interaction with 2,3-BPG is _______ resulting in an _______ affinity for O2 and a greater stabilization of the R state. This allows for a more efficient transfer of O2 from maternal to fetal hemoglobin
answer
weaker; increased
question
There are ___ O2 binding sites on one hemoglobin.
answer
4
question
Each O2 binding site is __________.
answer
cooperative
question
Oxygen is a ________ _________ effector.
answer
homotropic positive
question
Positive effectors shift the binding curve to the ______.
answer
left
question
If the binding curve is shifted left, this means that you achieve oxygen saturation slower/quicker?
answer
quicker
question
oxygen saturation is a combination of _________ and __________ hemoglobin.
answer
oxygenated; deoxygenated
question
percentage of hemoglobin molecules that are oxygenated is called:
answer
oxygen saturation
question
Saturation is maximum at _____ O2 pressure, such as in the ______.
answer
high; lungs
question
As hemoglobin moves to peripheral organs and the O2 pressure ____, _______ drops allowing O2 to be supplied to the ________.
answer
drops; saturation; tissues
question
At _______ pO2, small differences in O2 pressure result in big changes in O2 saturation of hemoglobin. This facilitates _________ of O2 in _________ __________.
answer
lower; dissociation; peripheral tissues
question
Describes the rightwards shift in the O2 saturation curve with increasing H+ concentration because oxygen is released more readily (higher CO2 & BPG cause same effect)
answer
The Bohr Effect
question
O2 is released in tissues where [H+] is____ due to CO2 production by metabolism
answer
high
question
What is the byproduct of anaerobic glycolysis if the RBC?
answer
2,3-Bisphosphoglycerate
question
2,3-Bisphosphoglycerate reacts with what?
answer
only deoxygenated RBC
question
when pO2 is decreased, as in chronic tissue deprivation of O2, the level of 2,3-BPG _________. This results in a further_________ shift of the curve facilitating O2 release to the deprived tissues
answer
increases; rightward
question
What causes carbon monoxide poisoning?
answer
Affinity of globin bound heme for CO is 104 times more then that for O2; thus, it will bind preferentially
question
Bound CO allosterically _______ hemoglobin (shifts O2 saturation curve to the _____)
answer
activates; left
question
During carbon monoxide poisoning, Any __ already bound can/can not be released (trapped in R state) so its transport to tissues becomes seriously compromised
answer
O2; cannnot
question
How do you treat CO2 poisoning?
answer
Hyperbaric O2 therapy (administration of 100% O2) is used to treat CO poisoning
question
Fibrous proteins exhibit special _________
properties, based on structure obtained from
combination of specific amino acids in regular,
___________ structural elements
answer
mechanical; secondary
question
Fibrous protein molecules have _______, _________
shape
answer
long, narrow
question
Fibrous proteins usually exist as __________
aggregates (fibers) of many protein chains.
answer
insoluble
question
_________ is a structural connective tissue accounting 30% of total body protein.
answer
collagen
question
Collagen has how many aa residues per chain?
answer
1000
question
How much of our protein is collagen?
answer
30%
question
Many types of collagen super-family exist. Types I-III are _____ forming while IV is ________ type.
answer
fiber; membrane
question
What are some properties of collagen and where do you find it in the body?
answer
insoluble, high tensile strength,
tendons, ligaments, cartilage, cornea
question
What is the primary amino acid sequence for collagen?
answer
(Gly-X-Y) is the primary amino acid sequence, X is often proline.
question
Collagen contains what?
answer
Contain hydroxyproline & hydroxylysine
question
Collagen may also be _________-addition of glucose or galactose before triple helix formation
answer
glycosylated
question
Collagen is synthesized by:
answer
fibroblasts, osteoblasts and condrocytes
question
Where is elastin found?
answer
vascular wall, skin, and lungs
question
What is the difference between elastin and collagen?
answer
Contain proline and glycine like collagen but the protein is not glycosylated and has minimal hydroxylation
question
What gives tissues (bladder, skin, lung blood vessels) their elasticity & resilience (recoil after a stretch)
answer
elastin
question
Large ________ ______ fibrils are interwoven to ______ the stretching and prevent the tissue from _________.
answer
inelastic collagen; limit; tearing
question
Aka brittle bone disease

Mutation in type I collagen genes

1. Prevent triple helix formation
2. Bendy bones, fracture, rotated & twisted spine
3. humpback
4. Type II OI-fatal in utero
answer
Osteogenesis imperfecta
Get an explanation on any task
Get unstuck with the help of our AI assistant in seconds
New