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Gilteritinib C29H44N8O3 structure – Flashcards

Flashcard maker : Jonathan Walsh

Contents

Experimental Solubility:
Bio Activity:

Molecular Formula	C₂₉H₄₄N₈O₃
Average mass	552.711 Da
Density	1.2±0.1 g/cm³
Boiling Point	696.9±55.0 °C at 760 mmHg
Flash Point	375.3±31.5 °C
Molar Refractivity	157.8±0.3 cm³
Polarizability	62.5±0.5 10^-24cm³
Surface Tension	60.2±3.0 dyne/cm
Molar Volume	444.9±3.0 cm³

Experimental data
Predicted – ACD/Labs
Predicted – ChemAxon

Experimental Physico-chemical Properties
- Experimental Solubility:
  
  100 mM in DMSO MedChem Express HY-12432
  
  10Mm in DMSO MedChem Express HY-12432

Miscellaneous

Bio Activity:

Axl MedChem Express HY-12432

Axl FLT3 MedChem Express HY-12432

Gilteritinib(ASP-2215) is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/<1 nM respectively; shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.; IC50 value: 0.29 nM(FLT3); <1 nM(Axl kinase); Target: FLT3/AXL inhibitor; ASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. MedChem Express HY-12432

Gilteritinib(ASP-2215) is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/<1 nM respectively; shows potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.;IC50 value: 0.29 nM(FLT3); <1 nM(Axl kinase);Target: FLT3/AXL inhibitorASP2215 inhibited the growth of MV4-11 cells, which harbor FLT3-ITD, with an IC50 value of 0.92 nM, accompanied with inhibition of pFLT3, pAKT, pSTAT5, pERK, and pS6. ASP2215 decreased tumor burden in bone marrow and prolonged the survival of mice intravenously transplanted with MV4-11 cells. ASP2215 may have potential use in treating AML. MedChem Express HY-12432

Protein Tyrosine Kinase/RTK MedChem Express HY-12432

Protein Tyrosine Kinase/RTK; MedChem Express HY-12432

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density:	1.2±0.1 g/cm³
Boiling Point:	696.9±55.0 °C at 760 mmHg
Vapour Pressure:	0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization:	102.1±3.0 kJ/mol
Flash Point:	375.3±31.5 °C
Index of Refraction:	1.627
Molar Refractivity:	157.8±0.3 cm³
#H bond acceptors:	11
#H bond donors:	4
#Freely Rotating Bonds:	9
#Rule of 5 Violations:	2

ACD/LogP:	4.35
ACD/LogD (pH 5.5):	1.03
ACD/BCF (pH 5.5):	1.00
ACD/KOC (pH 5.5):	4.53
ACD/LogD (pH 7.4):	2.89
ACD/BCF (pH 7.4):	54.79
ACD/KOC (pH 7.4):	327.45
Polar Surface Area:	121 Å²
Polarizability:	62.5±0.5 10^-24cm³
Surface Tension:	60.2±3.0 dyne/cm
Molar Volume:	444.9±3.0 cm³

Click to predict properties on the Chemicalize site

Gilteritinib C29H44N8O3 structure – Flashcards

Experimental Solubility:

Bio Activity:

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