Exam 4 Chemistry Review/Study Questions Part 4 – Flashcards

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question
What is the formula for the % Tf Saturation?
answer
(Total Iron / TIBC ) x 100
question
True or False:
Ferritin levels in serum will decrease BEFORE total iron content is depressed
answer
True
question
What does Total Serum Iron Measure?
answer
Iron bound to Tf
question
What is Transferrin often measured by?
answer
Nephelometry
question
What is Total Iron Binding Capacity a measure of?
answer
Capacity of transferrin to bind more iron
question
Usually Tf is what percent saturated with iron?
answer
20-50%
question
What is the formula to calculate TIBC knowing Tf?
answer
TIBC = Tf x 1.25
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True or False:
You can not calculate TIBC if Tf<70
answer
True
question
True or False:
You can not calculate % Tf Saturation is TIBC<5
answer
True
question
Name the condition associated with the following:
Iron - Decreased
Ferritin - Decreased
Transferrin - Increased
RBC Count - Decreased
H&H - Decreased
MCHC - Decreased
Micro/Hypo
answer
IDA
question
Name the condition associated with the following:
Iron - Increased
Ferritin - Increased
Transferrin - Decreased
Hemochromatosis
answer
Iron Overload
question
Name the condition associated with the following:
Iron - Decreased
Ferritin - Normal to Increased
Transferrin - Decreased
answer
Anemia of Chronic Disease
question
What is the term used to describe hereditary iron overload disease?
answer
Hemochromatosis
question
What can you use to treat Iron Overload?
answer
Therapeutic phlebotomy or chelators
question
Which iron disorder is connected to the following:
Cancer
Hogkins
SLE
Renal failure with decreased erythropoietin
answer
Anemia of Chronic Disease
question
Given the following Determine the Iron Disease State:
Total Fe - Decreased
Ferritin - Decreased
Transferrin - Increased
TIBC - Increased
% Saturation - Decreased
answer
IDA
question
Given the following Determine the Iron Disease State:
Total Fe - Increased
Ferritin - Increased
Transferrin - Decreased
TIBC - Decreased
% Saturation - Increased
answer
Hemochromatosis
question
Given the following Determine the Iron Disease State:
Total Fe - Decreased
Ferritin - Normal to Increased
Transferrin - Decreased
TIBC - Decreased
% Saturation - Decreased
answer
Anemia of Chronic Disease
question
Match the trace element with the deficiency results:
o Hypochromic anemia
o Bone malformation
o Menke's syndrome
o Wilson's disease
answer
Copper
question
Match the trace element with the deficiency results:
o Impaired immunity and wound healing
o Impotence
o Growth retardation
oSensory alterations
answer
Zinc
question
Match the trace element with the deficiency results:
o Megaloblastic anemia
answer
Cobalt
question
Match the trace element with the deficiency results:
o Reduced glucose tolerance
answer
Chromium
question
Match the trace element with the deficiency results:
o Bone defects and stunted growth
o Clotting disorders
o Epilepsy
answer
Manganese
question
Match the trace element with its Functions:
Erythropoiesis
Cellular respiration
Skeletal development
Nucleic acid/protein synthesis
Collagen formatio
answer
Copper
question
Match the trace element with its Functions:
Enzyme structure
RNA/DNA synthesis
Sensory development
Growth
Wound healing
Immune response
answer
Zinc
question
Match the trace element with its Functions:
Constituent of Vit B12
Needed for folate metabolism
answer
Cobalt
question
Match the trace element with its Functions:
“Glucose Tolerance Factor”,
increases effects of insulin
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Chromium
question
Match the trace element with its Functions:
Enzyme activator
Reproductive function
Bone and tissue formation
answer
Manganese
question
What is the formula of the Henderson-Hasselbalch Equation?
answer
pH = pK' + log (Buffer/Acid)
question
Define the following:
Acid
answer
Yield hydrogen ions (H+) when dissolved in H2O
Primary sources in the blood:H+, H2CO3 (carbonic acid) and pCO2
question
Define the following:
Base
answer
Yield hydroxyl ions (OH-)
Primary source in the blood: HCO3 (bicarbonate)
question
Define the following:
Buffer
answer
A system consisting of a weak acid and
a weak base that resists pH changes
question
Great quantities of H+ come from where?
answer
Cell metabolism and food digestion
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Define the following:
Total CO2
answer
The sum of the various CO2-containing substances in plasma
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Acidemia/acidosis = arterial pH below
answer
7.35
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Alkalemia/alkalosis = arterial pH above
answer
7.45
question
What are the various CO2-containing substances in plasma?
answer
Dissolved CO2 gas from cellular respiration (pCO2)
Carbonic acid (H2CO3)
Bicarbonate ion (HCO3-)
question
Total CO2 = ______ mmol/L
answer
23-29
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HCO3 = ________mmol/L
answer
22-26
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True or False:
Bicarbonate-Carbonic Acid System is the principle buffering system
answer
True
question
Normally, the ratio of HCO3 to CO2 is _____
answer
20:1
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A fall in the ratio of HCO3 to CO2 results in what?
answer
Acidosis
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A rise in the ratio of HCO3 to CO2 results in what?
answer
Alkalosis
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What 2 organs will respond to restore the 20:1 HCO3 to CO2 ratio?
answer
Lungs and/or Kidneys
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True or False:
If plasma becomes acidic, HCO3 can diffuse out of the RBC to buffer the blood
answer
True
question
As HCO3 diffuses out of the RBC to buffer the blood, what moves in?
answer
Chloride
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____ventilation: More CO2 is lost and blood becomes alkaline
answer
Hyperventillation
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____ventilation: CO2 accumulates and blood becomes acidic
answer
Hypoventilation
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True or False:
The response time to ventilation changes occurs within seconds
answer
True
question
True or False:
Tubules will excrete or retain acid (H+) or alkaline (HCO3)
answer
True
question
When H+ is retained by the kidneys, what is excreted?
answer
Na+
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When Na+ is retained by the kidneys, what is excreted?
answer
H+
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As H+ is excreted or Retained by the kidneys, what moves with it?
answer
K+
question
Correction of pH may take how much time when regulated by the kidneys?
answer
2-4 days
question
What is it called when:
pH has returned to normal, other 2 parameters are abnormal
answer
Fully Compensated
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What is it called when:
the pH and 1 other parameter are abnormal
answer
Uncompensated
question
What is it called when:
All 3 parameters are abnormal
answer
Partially Compensated
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