Exam 4 Chemistry Review/Study Questions Part 4 – Flashcards
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            | What is the formula for the % Tf Saturation? | 
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        | (Total Iron / TIBC ) x 100 | 
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            | True or False: Ferritin levels in serum will decrease BEFORE total iron content is depressed | 
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        | True | 
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            | What does Total Serum Iron Measure? | 
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        | Iron bound to Tf | 
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            | What is Transferrin often measured by? | 
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        | Nephelometry | 
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            | What is Total Iron Binding Capacity a measure of? | 
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        | Capacity of transferrin to bind more iron | 
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            | Usually Tf is what percent saturated with iron? | 
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        | 20-50% | 
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            | What is the formula to calculate TIBC knowing Tf? | 
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        | TIBC = Tf x 1.25 | 
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            | True or False: You can not calculate TIBC if Tf<70 | 
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        | True | 
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            | True or False: You can not calculate % Tf Saturation is TIBC<5 | 
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        | True | 
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            | Name the condition associated with the following: Iron - Decreased Ferritin - Decreased Transferrin - Increased RBC Count - Decreased H&H - Decreased MCHC - Decreased Micro/Hypo | 
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        | IDA | 
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            | Name the condition associated with the following: Iron - Increased Ferritin - Increased Transferrin - Decreased Hemochromatosis | 
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        | Iron Overload | 
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            | Name the condition associated with the following: Iron - Decreased Ferritin - Normal to Increased Transferrin - Decreased | 
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        | Anemia of Chronic Disease | 
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            | What is the term used to describe hereditary iron overload disease? | 
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        | Hemochromatosis | 
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            | What can you use to treat Iron Overload? | 
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        | Therapeutic phlebotomy or chelators | 
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            | Which iron disorder is connected to the following: Cancer Hogkins SLE Renal failure with decreased erythropoietin | 
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        | Anemia of Chronic Disease | 
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            | Given the following Determine the Iron Disease State: Total Fe - Decreased Ferritin - Decreased Transferrin - Increased TIBC - Increased % Saturation - Decreased | 
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        | IDA | 
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            | Given the following Determine the Iron Disease State: Total Fe - Increased Ferritin - Increased Transferrin - Decreased TIBC - Decreased % Saturation - Increased | 
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        | Hemochromatosis | 
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            | Given the following Determine the Iron Disease State: Total Fe - Decreased Ferritin - Normal to Increased Transferrin - Decreased TIBC - Decreased % Saturation - Decreased | 
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        | Anemia of Chronic Disease | 
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            | Match the trace element with the deficiency results: o Hypochromic anemia o Bone malformation o Menke's syndrome o Wilson's disease | 
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        | Copper | 
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            | Match the trace element with the deficiency results: o Impaired immunity and wound healing o Impotence o Growth retardation oSensory alterations | 
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        | Zinc | 
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            | Match the trace element with the deficiency results: o Megaloblastic anemia | 
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        | Cobalt | 
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            | Match the trace element with the deficiency results: o Reduced glucose tolerance | 
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        | Chromium | 
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            | Match the trace element with the deficiency results: o Bone defects and stunted growth o Clotting disorders o Epilepsy | 
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        | Manganese | 
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            | Match the trace element with its Functions: Erythropoiesis Cellular respiration Skeletal development Nucleic acid/protein synthesis Collagen formatio | 
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        | Copper | 
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            | Match the trace element with its Functions: Enzyme structure RNA/DNA synthesis Sensory development Growth Wound healing Immune response | 
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        | Zinc | 
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            | Match the trace element with its Functions: Constituent of Vit B12 Needed for folate metabolism | 
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        | Cobalt | 
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            | Match the trace element with its Functions: “Glucose Tolerance Factor”, increases effects of insulin | 
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        | Chromium | 
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            | Match the trace element with its Functions: Enzyme activator Reproductive function Bone and tissue formation | 
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        | Manganese | 
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            | What is the formula of the Henderson-Hasselbalch Equation? | 
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        | pH = pK' + log (Buffer/Acid) | 
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            | Define the following: Acid | 
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        | Yield hydrogen ions (H+) when dissolved in H2O Primary sources in the blood:H+, H2CO3 (carbonic acid) and pCO2 | 
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            | Define the following: Base | 
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        | Yield hydroxyl ions (OH-) Primary source in the blood: HCO3 (bicarbonate) | 
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            | Define the following: Buffer | 
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        | A system consisting of a weak acid and a weak base that resists pH changes | 
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            | Great quantities of H+ come from where? | 
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        | Cell metabolism and food digestion | 
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            | Define the following: Total CO2 | 
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        | The sum of the various CO2-containing substances in plasma | 
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            | Acidemia/acidosis = arterial pH below | 
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        | 7.35 | 
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            | Alkalemia/alkalosis = arterial pH above | 
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        | 7.45 | 
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            | What are the various CO2-containing substances in plasma? | 
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        | Dissolved CO2 gas from cellular respiration (pCO2) Carbonic acid (H2CO3) Bicarbonate ion (HCO3-) | 
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            | Total CO2 = ______ mmol/L | 
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        | 23-29 | 
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            | HCO3 = ________mmol/L | 
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        | 22-26 | 
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            | True or False: Bicarbonate-Carbonic Acid System is the principle buffering system | 
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        | True | 
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            | Normally, the ratio of HCO3 to CO2 is _____ | 
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        | 20:1 | 
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            | A fall in the ratio of HCO3 to CO2 results in what? | 
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        | Acidosis | 
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            | A rise in the ratio of HCO3 to CO2 results in what? | 
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        | Alkalosis | 
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            | What 2 organs will respond to restore the 20:1 HCO3 to CO2 ratio? | 
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        | Lungs and/or Kidneys | 
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            | True or False: If plasma becomes acidic, HCO3 can diffuse out of the RBC to buffer the blood | 
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        | True | 
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            | As HCO3 diffuses out of the RBC to buffer the blood, what moves in? | 
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        | Chloride | 
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            | ____ventilation: More CO2 is lost and blood becomes alkaline | 
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        | Hyperventillation | 
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            | ____ventilation: CO2 accumulates and blood becomes acidic | 
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        | Hypoventilation | 
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            | True or False: The response time to ventilation changes occurs within seconds | 
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        | True | 
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            | True or False: Tubules will excrete or retain acid (H+) or alkaline (HCO3) | 
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        | True | 
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            | When H+ is retained by the kidneys, what is excreted? | 
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        | Na+ | 
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            | When Na+ is retained by the kidneys, what is excreted? | 
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        | H+ | 
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            | As H+ is excreted or Retained by the kidneys, what moves with it? | 
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        | K+ | 
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            | Correction of pH may take how much time when regulated by the kidneys? | 
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        | 2-4 days | 
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            | What is it called when: pH has returned to normal, other 2 parameters are abnormal | 
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        | Fully Compensated | 
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            | What is it called when: the pH and 1 other parameter are abnormal | 
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        | Uncompensated | 
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            | What is it called when: All 3 parameters are abnormal | 
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        | Partially Compensated | 
