Exam 3 Liver Disorders & Lab Analysis

question

With which Disorder is the following associated with:
[image]
answer

Cirrhosis
question

What is the main cause of a Fatty Liver?
answer

Alcoholism
question

What may a Fatty Liver progress to?
answer

Alcoholic Hepatitis
Permanent Cirrhosis
question

How would you describe Hepatitis?
answer

Inflammation of the liver
question

What Disorder are the following associated with?
Bacteria, parasites, radiation, alcohol, drugs, chemicals, toxins, Jaundice
answer

Hepatitis
question

Describe the chemical tests for Hepatitis in association with bilirubin, albumin, AST, and ALT
answer

Increased Direct & Indirect Bilirubin
Positive Urine Bilirubin
Increased ALT & AST
Decreased Albumin
question

What are the 2 leading causes of Cirrhosis?
answer

Alcohol Abuse
Chronic HCV
question

Cirrhosis causes what type of abilities of the liver to be reduced?
answer

Synthesizing
question

What will be increased and decreased in Cirrhosis?
answer

Decreased Albumin
Decreased Clotting Factors
Increased GGT
Increased PT
question

True or False:
Cirrhosis causes a decrease in albumin and clotting factors which leads to an increase in PT and bleeding disorders
answer

True
question

What type of electrophoresis pattern is associated with Cirrhosis?
answer

Beta-Gamma Bridging
question

What is the 12th leading cause of death in the United States of America?
answer

Cirrhosis
question

What can be attributable to HBV & HCV?
answer

Tumors
question

What is the marker for tumors due to liver disorders?
answer

AFP
question

What disorder is usually following a viral or URT infection?
answer

Reye’s Syndrome
question

Which disorder is associated with aspirin use?
answer

Reye’s Syndrome
question

Reye’s Syndrome is associated with increased levels of what 3 substances?
answer

Ammonia
ALT
AST
question

What are most Drug-Induced Disorders of the Liver associated with?
answer

Ethanol
question

What over-the-counter drug is often associated with Drug-Induced Disorders of the Liver?
answer

Acetaminophen
question

Which disorder are the following attributed to:
Inherited iron storage disease
Sideroblastic anemia results
Pigmentation to skin
answer

Hemochromatosis
question

What type of stain helps visualize iron deposits?
answer

Prussian Blue
question

What method is the following consistent with?
Serum + Diazo Reagent –> Azobilirubin
answer

Conjugated Bilirubin
question

What method is the following consistent with?
Serum + Accelerator + Diazo Reagent –>
Azobilirubin
answer

Total Bilirubin (Conjugated + Unconjugated)
question

What methods is the following consistent with?
Azobilirubin + Alk Tartrate –> Blue color at 600 nm
answer

Total Bilirubin (Conjugated + Unconjugated)
& Conjugated Bilirubin
question

Serum + Diazo Reagent –> ?
answer

Azobilirubin
question

Serum + Accelerator + Diazo Reagent –> ?
answer

Azobilirubin
question

Azobilirubin + Alk Tartrate –> ?
answer

Blue color at 600 nm
question

Malloy & Evelyn method uses what?
answer

Methanol Accelerator
question

Jendrassik-Grof method uses what?
answer

Caffeine Accelerator
question

What is Delta Bilirubin?
answer

Conjugated bilirubin bound to albumin
question

What is Delta Bilirubin seen in?
answer

Severe Liver Obstruction
question

What does Delta Bilirubin react as in testing?
answer

Conjugated Bilirubin
question

Who should a Direct Spectrophotometry be used on?
answer

Newborn Serum that does not contain carotinoids
question

Direct Spectrophotometry – Absorbance at _______ is proportional to concentration
answer

450 nm
question

Direct Spectrophotometry – After the child is 1 month of age what method do you use?
answer

Jendrassik-Grof Method
question

What method measures light reflected from the skin?
answer

Transcutaneous Method
question

Who should the Transcutaneous Method be used on?
answer

Newborn Serum that does not contain carotinoids
question

Where is urobilinogen detected at?
answer

Urine
Feces
question

What reagent do you use with urobilinogen to get a colored compound?
answer

Ehrlich’s Reagent
question

Low levels of what is seen in malnutrition or starvation?
answer

Albumin
question

A prolonged PT indicates severe what?
answer

diffuse liver disease
question

Is a prolonged PT a good prognosis or a bad prognosis?
answer

bad prognosis
question

You will see increased levels of what in Reye’s Syndrome, Cirrhosis, Drug Toxicity, and Hepatoma?
answer

Ammonia
question

What can you use Ammonia to assess?
answer

Detoxification and Excretion Function of the Liver
question

Encephalopathy =
answer

Hepatic Coma
question

Enzymes are considered indicators of ____ _____ rather than cell function?
answer

cell damage
question

What type of disorder are the following associated with:
ALP: N
GGT: N
AST/ALT: N
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: N
Urine Bilirubin: Negative
Urine Urobilinogen: Increased
answer

Prehepatic
question

What type of disorder are the following associated with:
ALP: Increased
GGT: Increased
AST/ALT: VERY Increased
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: Increased
Urine Bilirubin: Positive
Urine Urobilinogen: N/Increased
answer

Hepatic
question

What type of disorder are the following associated with:
ALP: N/Increased
GGT: VERY Increased
AST/ALT: Increased
Albumin: Decreased
Total Bilirubin: Increased
Direct Bilirubin: N/Increased
Urine Bilirubin: Various
Urine Urobilinogen: Various
answer

Alcoholic Hepatitis
question

What type of disorder are the following associated with:
ALP: VERY Increased
GGT: Very Increased
AST/ALT: Increased
Albumin: N
Total Bilirubin: Increased
Direct Bilirubin: Increased
Urine Bilirubin: Positive
Urine Urobilinogen: Decreased
answer

Obstruction
question

Match the findings with the condition:
Inherited iron storage disease causing sideroblastic anemia
answer

Hemochromatosis
question

Match the findings with the condition:
Leading cause of cirrhosis; elevated GGT, beta-gamma bridging
answer

Alcoholism
question

Match the findings with the condition:
Highest levels of AST and ALT seen
answer

Viral hepatitis
question

Match the findings with the condition:
Liver disease following the flu; elevated ammonia
answer

Reye’s syndrome
question

Match the findings with the condition:
Alpha fetoprotein used as a marker
answer

Hepatoma
question

Match the findings with the condition:
Gallstones cause the appearance of pale stools
answer

Obstructive jaundice
question

Match the bilirubin results with the most likely condition:
Posthepatic jaundice
answer

Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
question

Match the bilirubin results with the most likely condition:
Obstruction
answer

Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
question

Match the bilirubin results with the most likely condition:
Hemolytic anemia
answer

Increased indirect bilirubin; increased urine urobilinogen
question

Match the bilirubin results with the most likely condition:
Viral hepatitis
answer

Increased direct & Increased Indirect Bilirubin; positive urine bilirubin and urobilinogen
question

Match the bilirubin results with the most likely condition:
Gallstones
answer

Increased direct bilirubin, positive urine bilirubin,
negative urine urobilinogen, pale stools
question

Match the bilirubin results with the most likely condition:
Prehepatic jaundice
answer

Incrased indirect bilirubin; increased urine urobilinogen
question

What over-the-counter drug is highly toxic to the liver?
answer

acetaminophen
question

What protein is decreased in liver disease, but also decreased in malnutrition and starvation?
answer

Albumin
question

Name the coagulation test that, when prolonged, may be an indicator of diffuse liver disease.
answer

PT
question

What liver enzyme is commonly elevated in bile duct obstructions?
answer

ALP & GGT
question

What is the purpose of the caffeine accelerator in the J-G method for total bilirubin?
answer

Converts indirect bilirubin to water soluble form
question

How should specimens for bilirubin analysis be stored?
answer

Protect from light
question

How will hemolysis affect test results?
answer

Falsely decreases
question

What methodology is commonly used to test for bilirubin in the serum of newborns?
answer

Direct spectro
question

What is Delta bilirubin?
answer

Direct bilirubin bound to albumin
question

In what condition will delta bilirubin be elevated?
answer

Severe obstruction

Get instant access to
all materials

Become a Member