Chapter 20 21 Lymphatic System and Immunity Pearson Marieb Anatomy and Physiology – Flashcards
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A "nonself" substance that can provoke an immune response is called a(n)
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Antigen
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Active artificially acquired immunity is a result of
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Vaccination
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Complement proteins work by
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Forming pores in the membranes of target cells
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Cytotoxic T cells kill target cells
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Through insertion of perforins into the target's membrane
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Lymphocytes that develop immunocompetence in the thymus are
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T lymphocytes
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Saliva and lacrimal fluids contain this enzyme that destroys bacteria
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Lysozyme
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The immune cell is able to respond quickly after any subsequent encounter with the same antigen
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Memory cell
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These molecules are secreted by leukocytes and macrophages and result in a fever
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Pyrogens
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This type of disease results from the inability of the immune system to distinguish self-from nonself-antigens
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Autoimmune disease
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When a localized area exhibits increased capillary filtration, hypermia, and swelling it is an indication that
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Inflammation is occuring
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Which cell does NOT have a direct role in phagocytosis?
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NK cells
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Which cells stimulate both arms of the immune response?
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Helper T cells
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Which nonspecific defense cells specialize in attacking cancer cells and virus-infected cells?
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Natural killer cells
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Which of the following is a nonspecific barrier defense?
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Mucous membranes
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Which statement below is characteristic of a secondary humoral response?
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It occurs much more than a primary response.
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Which type of molecule is produced by virus infected cells to communicate to noninfected cells the presence of a virus?
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Interferon
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Which of the following is NOT a surface barrier to pathogen influx?
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Complement cascade
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Which of the following is NOT one of the cardinal signs of inflammation?
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Opsonization
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The process that begins when a helper T cell binds to a class II MHC protein on a displaying cell is known as
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Costimulation
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All of the following are examples of autoimmune disorders, EXCEPT
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Sickle-cell anemia
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Which of the following is NOT an innate defense mechanism of the body?
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B lymphocytes
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Which of the following steps is the first step in an inflammatory response?
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Release of leukocytosis-inducing factor
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In the respiratory burst, ____ are released, which have a potent cell-killing ability
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Free radicals
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Leukotrienes cause
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Dilation of the small blood vessels in an injured area
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Toll-like receptors are found on
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Macrophages
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Interferons can be used to treat all of the following, EXCEPT
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Muscular dystrophy
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All of the following are functions of interferons, EXCEPT that_____
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They only occur naturally
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Which of the following minerals needed fro bacterial reproduction do both the liver and spleen sequester during a fever?
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Zinc
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Which hypersensitivity is caused by T lymphocytes:
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Delayed
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Without _______ there is no adaptive immune response
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T lymphocytes
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Left subclavian vein
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Into which blood vessel will lymph flow if it starts at the red arrow?
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cytotoxic T
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The cells directly responsible for cellular immunity are the ________ cells.
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Tonsils
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________ are large lymphatic nodules that are located in the walls of the pharynx.
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Plasma
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The cells responsible for the production of circulating immunoglobulins are ________ cells.
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Bone Marrow
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Stem cells that will form B cells or NK cells are found only in the
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NK cells recognize abnormal or cancer cells by a specific antigen on their cell membrane.
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Which of the following is NOT a characteristic of Natural Killer (NK) cells? -NK cells recognize abnormal or cancer cells by a specific antigen on their cell membrane. - NK cells attack transplanted organs. -NK cells induce the target cell to undergo "apoptosis" (cell suicide). -NK cells attack infected or cancerous cells.
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interferons
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What innate internal defenses work by interfering with viral replication?
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The phagocytes recognize molecules on pathogens not normally found on body cells.
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How do phagocytes recognize foreign cells or bacteria?
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complement proteins
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Which of the innate defense mechanisms can lyse bacteria and mark cells for phagocytosis?
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antibodies and complement proteins
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What can act as opsonins on bacteria, thus enhancing phagocytosis?
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NK
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The cells that perform immunological surveillance are the ________ cells.
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passive immunization
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In an experimental situation, a rabbit is exposed to a viral antigen to which it makes antibodies. These antibodies are then purified and injected into a human with the same viral disease. This is an example of?
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antigen-presenting cells
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Class II MHC proteins are found on which of the following cell types?
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class II MHC proteins
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Which class of MHC proteins presents exogenous antigens?
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CD8
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Class I MHC proteins are recognized by which of the following cell types (that are destined to become T cells)?
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all nucleated cells
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What types of cells display protein fragments produced by the cancer within them?
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CD8
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Which major class of lymphocytes become cytotoxic T cells?
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cytotoxic T lymphocytes
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Which defense cells can specifically identify and directly kill disease cells?
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cytotoxic T
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When an antigen is bound to a Class I MHC molecule, it can stimulate a ________ cell.
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IgE
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Which class of immunoglobulins sensitizes cells to allergens?
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innate external defenses
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Tears and mucus membranes would be a part of which defense system?
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innate internal defenses
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Phagocytotic cells such as macrophages identify a variety of enemies by recognizing markers unique to pathogens. They would be classified as which type of defense system?
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plasma B cells
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What cells make antibodies?
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antigenic determinant
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What is the name of the unique area (specific region) that a lymphocyte recognizes and binds to?
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humoral immunity
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What type of immunity can be transferred by bodily fluids from one person to another, thus conferring immunity to the recipient?
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cellular immunity
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If a virus attacks a cell, which type of immunity would be activated?
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Cytotoxic T cells
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Cancer cells would be attacked by which of the following cells?
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Helper T Cells
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B cells are primarily activated by the activities of
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bone marrow and thymus
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Which of the following are primary lymphoid organs?
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white pulp of the spleen
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Which of the following areas in a secondary lymphoid organ allows intimate contact between blood and the lymphocytes?
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deep in the cortex
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Where in the lymph node do the T cells first encounter antigens presented by dendritic cells?
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germinal centers of the cortex
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Where in the lymph node do the B cells first encounter antigens presented by dendritic cells?
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Peyer's patches
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Collections of lymphoid tissues, called MALT, are strategically placed throughout the respiratory, digestive, and genitourinary systems. Which one of these is located at the end of the small intestine?
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thymus
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There is a decrease in our ability to fight infection as we age. Which lymphoid organ may have a role in this decline?
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lymphocytes
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The lymphoid tissue of the spleen ("white pulp") contains many __________.
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right arm
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Which of these organs does not drain its lymph into the thoracic duct? -left leg - right leg - left arm - right arm
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B
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The cells responsible for humoral immunity are the ________ cells.
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cytotoxic T
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Lymphocytes that destroy foreign cells or virus-infected cells are ________ cells.
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naturally acquired active
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Immunity that results from exposure to an antigen in the environment is called ________ immunity.
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IgG
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Immunoglobulins that are most abundant and are responsible for resistance against many viruses, bacteria, and bacterial toxins are
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False
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( T or F ) Lymph is important in transporting carbohydrates.
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False
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( T or F ) The right lymphatic drains 3/4 of the body.
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submandibular, cervical, axillary, inguinal
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List places large clusters of lymph nodes are found
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lymphocytes
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The white pulp of the spleen is important because it contains?
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Because it provides a physical and chemical barrier to pathogens
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Why is the skin called the "first line of defense"?
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kupffer cells
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Which of the following is a type of fixed macrophage? a. kupffer cells b. leukocytes c. T cells d. monocytes
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helper T cells
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Which T cell is responsible for stimulating B cells?
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plasma cell
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Which of the following cells makes and releases antibodies?
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Creating your own antibodies either by actually getting the illness or through a vaccine
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Define active immunity
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afferent lymphatic vessels
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Lymph vessels that conduct lymph into a lymph node are termed
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maintain extracellular fluid balance, collect excess fluid from the interstitial space, defend the body against foreign cells and molecules
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The lymphatic system functions to?
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False
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( T or F ) Lymphatic capillaries are less permeable than systemic capillaries.
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intestinal, jugular, bronchomediastinal, lumbar, subclavian
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List lymphatic trunks
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produce RBC in fetus, break down old RBCs and store Fe , store platelets, surveillance of the immune system
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List functions of the spleen
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lymphatic are more permeable, lymphatic only move lymph toward the heart, detours through lymph glands
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List the differences between lymphatic capillaries and systemic capillaries
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False
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(T or F) Bacteria only live inside other cells
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False
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(T or F) A lymph node contains fewer afferent lymphatic vessels than efferent.
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Complement
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Which of the following are proteins which result in the formation of MAC?
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False
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T or F: The production of antibodies against an antigen is an example of nonspecific immunity.
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interferon
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What are antiviral proteins that also stimulate NK cells and macrophages?
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False
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T/F: Immunity from getting a vaccine is an example of active naturally acquired immunity.
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True
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T/F: Viruses only live inside other cells.
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True
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T/F: Immunity to an infant via breast milk is an example of passive naturally acquired immunity.
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return of tissue fluid to the cardiovascular system
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A major function of the lymphatic system is __________.
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Peyer's patches
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Aggregates of lymphoid nodules located in the wall of the ileum of the small intestine are __________.
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the thymus
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Collections of lymphoid tissue (MALT) that guard mucosal surfaces include all the following, EXCEPT __________.
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spleen
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In addition to its lymphoid function, this organ holds a reservoir of platelets.
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reticular connective tissue
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The lymphoid tissue's structural framework of is composed of __________.
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appendix
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This structure, attached to the cecum, is in an ideal location to destroy bacteria before they breach the intestinal wall.
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lymphatic capillary
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What lymphatic structure absorbs excess tissue fluid?
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lacteal
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What lymphatic structure absorbs lipids in the intestine?
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palatine tonsils
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What lymphatic structures trap bacteria in the posterior oral cavity?
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lymphocytes
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Which of the following are located in the spleen's white pulp?
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capillaries, vessels, trunks, ducts
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Which sequence best describes the flow of lymph through the lymphatic system?
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It maintains blood volume and, hence, pressure.
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Which statement below describes the lymphatic system's role in relation to the cardiovascular system?
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It drains the lymph from the entire left side of the body and the right abdomen and leg.
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Which statement is true of the thoracic duct?
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They have fewer efferent vessels than afferent vessels.
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Which statement is true about lymph nodes?
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a one-way system of vessels beginning with blind-ended lymphatic capillaries
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Which of the following best describes the arrangement of lymphatic vessels?
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thymus
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Which of the following is the major lymphoid organ that "trains" T lymphocytes to become immunocompetent?
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lymph nodes
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Which of the following are the principal lymphoid organs in the body?
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the tonsils
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The lymphoid organ(s) located in the throat that defend(s) against invading bacteria coming in through the mouth and nose is (are) __________.
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It is best to perform a splenectomy if the spleen is damaged in a car accident.
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Which of the following statements about the spleen is FALSE?
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lymphatics
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Which of the following vessels transport fluid that leaks from the vascular system back into the blood?
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CSF
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Excess tissue fluid in the brain drains into the __________.
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red lines under the skin that are sensitive to touch
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Lymphangitis presents itself as __________.
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transport of chyle
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Which of the following features is NOT common to both lymphatic collecting ducts and veins?
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germinal centers
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When B lymphocytes are dividing rapidly, the __________ of the lymphoid tissue enlarge(s).
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in the medullary cords
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Where are plasma cells found in a lymph node?
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lymph sinuses
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Large lymph capillaries in a lymph node spanned by crisscrossing reticular fibers are known as __________.
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monocytes
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Which of the following cells would NOT be found in a germinal center in a lymph node?
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spleen
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Which lymphatic structure may also be a site of erythrocyte production in the fetus?
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white pulp
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Areas of lymphocytes suspended by reticular fibers in the spleen are known as __________.
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that receives lymph drainage from a body area suspected of cancer
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A sentinel node is the first lymph node __________.
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False
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Blood plasma and lymph are identical except for their respective locations in the body.
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lymphatic capillaries
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What part of the lymphatic system is most closely associated with capillary beds?
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Lymphatic collecting vessels have endothelial flap valves, but veins do not.
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How are lymphatic collecting vessels different from veins?
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subclavian veins
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All lymph is eventually returned to circulation via the __________.
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delivery of nutrients to tissues
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Which of the following is NOT a function of lymphatic vessels?
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produces antibodies
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phagocytic cell
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phagocytic cell
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fibroblast-like cell that produces the reticular fiber stroma
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captures antigens and brings them back to lymph nodes
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produces antibodies
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fibroblast-like cell that produces the reticular fiber stroma
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captures antigens and brings them back to lymph nodes
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False
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Reticular connective tissue is found in all lymphoid organs and tissues.
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Lymph nodes produce lymph.
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Which of the following is NOT a characteristic of lymph nodes?
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afferent vessel, subcapsular sinus, medullary sinuses, efferent vessel
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Which of the following lists the correct order of lymph flow through the lymph node?
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serve as a site of T cell maturation
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Which of the following is NOT a role of the spleen?
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After puberty, the thymus begins to decrease in size.
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Choose the true statement about the thymus.
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gather and remove pathogens entering through the pharynx
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The main role of the tonsils is to __________.
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the spleen
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Which of the following is NOT a part of the mucosa-associated lymphatic tissue (MALT)?
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tonsils
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Except for the __________ and the spleen, the lymphoid organs are poorly developed at birth.
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lymphatic capillary
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collects excess tissue fluids
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right lymphatic duct
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drains right head and neck region
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thoracic duct
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larger of the two lymphatic ducts receiving lymph from all but the right head and neck region
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lymphatic trunk
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drains lymph from specific body areas
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lymph node
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houses lymphatic cells and filters lymph
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lymph noes
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large collections of bean-shaped structures in the inguinal, axillary, and cervical regions
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appendix
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a tubular offshoot from the cecum
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spleen
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a filter and reservoir for the blood
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thymus
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causes T cells to become immunocompetent
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tonsils
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invite infection to promote immunity
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lymphatic collecting vessels
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same three tunics as veins; the second-smallest lymph vessels
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lymphoid tissue
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a type of loose connective tissue called reticular connective tissue; dominates all lymphoid organs except thymus
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lymphatic trunks
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same three tunics as veins; the largest of lymph vessels
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lymphatic capillaries
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begin as blind-ended tubes that weave between tissue cells and blood capillaries in loose connective tissues; the smallest vessels
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lymph node
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bean-shaped structure surrounded by a dense fibrous capsule with fibrous strands that divide it into compartments
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lymphatic capillaries
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collects fluid that leaks from blood capillaries into tissue fluid
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lymph nodes
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distinct bean-shaped structures that "filter" lymph fluid as it is moved toward the circulatory system
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lymphatic ducts
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largest vessels; carry lymph fluid to subclavian veins
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lymphatic collecting vessels
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collect lymph fluid draining from lymphatic capillaries
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lymphoid tissue
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provides a proliferation site for lymphocytes and furnishes surveillance vantage point for lymphocytes and macrophages
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hilus
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the indented region on the concave side of the node leading into the efferent vessels
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subcapsular sinus
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a large, baglike structure leading into a number of small sinuses
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afferent lymphatic vessels
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vessels leading into lymph node
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efferent lymphatic vessels
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vessels leaving the lymph node
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tonsils
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lymphoid organs; found around the entrance to the pharynx
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mucosa-associated lymphatic tissue (MALT)
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small lymphoid tissues found in digestive and respiratory tracts
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spleen
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soft, blood-rich organ about the size of a fist (largest lymphoid organ)
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Peyer's patches
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isolated clusters of lymph follicles located mostly in the wall of the appendix
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thymus gland
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located in the inferior neck and extends into the superior thorax
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t cell
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deep cortex
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b cell
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within germinal center
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plasma cells
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medullary cords
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macrophages
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lymph sinus
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dendritic cells
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surrounding the germinal center
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Peyer's patches
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destroy bacteria in appendix; generate "memory" lymphocytes for long-term memory in intestine
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thymus
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important in early years of life by training T lymphocytes to become immunocompetent
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tonsils
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guard the throat by "inviting" bacteria into the lymphatic system and then destroying them
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MALT
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protects the digestive and respiratory tracts from never-ending onslaughts of foreign matter entering mucosa-lined cavities
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spleen
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provides a large, blood-filled site for lymphocyte proliferation and immune surveillance and response; cleanses the blood
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interstitial fluid
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What is the composition of lymph most similar to?
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Capillary beds
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Lymphatic collecting vessels are most closely associated with:
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Veins have fewer internal valves than do lymphatic vessels
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Which of the following statements is true regarding veins versus lymphatic collecting vessels?
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Venous circulation
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Once collected, lymph is returned to:
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return tissue fluid to the bloodstream
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Lymphatic vessels:
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Plasma cells
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Antibodies are produced by _______.
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Thymus
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Which of the following lymphoid tissues/organs does not contain reticular connective tissue?
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They filter lymph
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Which of the following is a role of lymph nodes?
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Bone marrow
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Which of the following is not a lymphoid tissue/organ?
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Palantine tonsils
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The ________ is (are) the most likely to become infected.
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along the small intestine
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Peyer's patches are located:
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thymus
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The first lymphoid organ to appear in development is (are) the:
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False
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Lymph arrives to the lymph nodes via efferent lymphatic vessels.
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True
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The thymus functions strictly in maturation of T cells.
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blood vessels
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Which of the following is NOT a part of the lymphatic system?
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increase permeability
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What is the role of the mini-valves in lymph capillaries?
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lymphocytes
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Which of the following are considered the primary immune system cells?
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lymph nodes
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What is/are the principal lymphoid organ(s) in the body?
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Spleen
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Which lymphoid organ provides a site for lymphocyte proliferation and immune surveillance and response and provides blood-cleansing functions?
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thymus gland
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Which lymphoid organ serves as the site where T lymphocytes become immunocompetent T cells?
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Tonsils
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Which of the following is/are the simplest lymphoid organ(s)?
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lymph nodes
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Which of the following is NOT a part of the MALT?
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distal portion of the small intestine
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Where are Peyer's patches located?
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eosinophil
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Which of the following is NOT a lymphoid cell?
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intact skin and mucous membranes
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What constitutes the body's first line of defense against disease?
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T cells
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Which of the following is NOT a nonspecific internal defense against disease?
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inflammation
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Which defense mechanism results in redness, heat, pain, and swelling?
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to develop antibodies against various diseases
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Why are children given vaccinations?
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interferon
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Which antimicrobial protein is produced by a virus-infected cell?
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It occurs immediately after the body is challenged by foreign material
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Which of the following does NOT describe the adaptive immune response?
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antigens
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What mobilizes the adaptive defenses and provokes an immune response?
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dendritic cells
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Which cells engulf antigens and present fragments of them on their own surfaces where they can be recognized by cells that will deal with them?
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helper T cell
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Which cell of the immune system is absolutely required for an adaptive immune response?
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processed fragments of protein antigens displayed on surfaces of body cells
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What types of antigen are recognized by T cells?
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T cells
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Which of the following is/are not a part of the innate immune defenses?
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antibodies
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Proinflammatory signals include all of the following except:
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Chemotaxis
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____________ is the final step of phagocyte mobilization.
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IFNs help the body combat viral infections
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Which of the following is a role of interferons (IFNs)?
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Opsonization
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Which of the following is an effect of complement activation?
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fever
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Pyrogens induce __________.
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T cells
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Cellular immunity is attributed to the action of:
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Thymus
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T cells achieve self-tolerance in the _______.
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Natural killer cells
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Which of the following does not serve as an antigen-presenting cell?
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A primary response results when naïve lymphocytes are activated, while a secondary response is a result of activating memory cells.
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Choose the true statement regarding the primary versus the secondary immune response.
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Natural passive
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___________ immunity protects a baby who is fed breast milk.
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IgG
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________ is the most abundant class of antibodies in plasma.
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T cytoxic cells
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________ are lymphocytes that directly kill virus infected cells.
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T helper cells
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Antigens bound to MHC II activate:
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The T cell enters a state of anergy.
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What occurs if a T cell binds to an antigen and the T cell does not receive a co-stimulatory signal?
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T helper cells
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_______ are lymphocytes that coordinate cellular and humoral immune responses.
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Immediate hypersensitivity: allergic contact dermatitis
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Which is mismatched?
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False
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Fever is one of the cardinal signs of inflammation.
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True
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MHC I proteins (major histocompatibility class I proteins) are found on most cells of the body.
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naturally actively acquired humoral immunity
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antibodies passed from mother to fetus via placenta, or to infant in her milk
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artificially actively acquired humoral immunity
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vaccine; dead or attenuated pathogens
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naturally passively acquired humoral immunity
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infection; contact with pathogen
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artificially passively acquired humoral immunity
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injection of immune serum (gamma globulin)
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1. Antigen invades body. 2. Plasma cells produce large amounts of class IgE antibodies against allergen. 3. IgE antibodies attach to mast cells in body tissues. 4. More of same antigen invades body. 5. Antigen combines with IgE attached to mast cells (and basophils), triggering degranulation and the release of histamine. 6. Histamine causes blood cells to dilate and become leaky.
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The stages of the allergic response.
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mast cells
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invoke inflammation when IgE cross-links to them
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helper T cells
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coordinate humoral and cellular immune responses
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plasma cells
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produce immunoglobulins
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macrophages
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a common APC
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gamma globulin
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a class of plasma protein
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opsonization
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this process encourages phagocytosis
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acid mantle
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covers the skin and limits bacterial growth
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leukocytosis
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characterized by high numbers of neutrophils
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saliva and tears
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contains the antibacterial enzyme called lysozyme
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skin
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first line of defense against invading organisms
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stomach mucosa
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produces HCl and enzymes that kill bacteria
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respiratory tract
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sticky mucous membrane lined with cilia
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natural killer cells
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a small subgroup of lymphocytes that will attack cancerous cells
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macrophages
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derived from circulating monocytes
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neutrophils
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phagocytes; will migrate to the site of an infection within a few hours
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hyperemia
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increased blood flow due to vasodilation of blood vessels entering the injured area
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chemotaxis
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the process by which white blood cells are attracted to the site of an injury
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exudate
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seeps from the capillaries and contains clotting factors and antibodies
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edema
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caused by excess blood flow to the injured area; helps to dilute harmful substances and brings in excess oxygen
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leukocytosis
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chemicals released from injured tissues stimulate rapid proliferation and release of cells
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margination
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neutrophils attach to CAMs on the endothelial linings in the injured area
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diapedesis
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neutrophils squeeze through walls of capillaries into the tissues
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chemotaxis
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inflammatory chemicals attract neutrophils to the injured areas
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helper T cells
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attack and lyse cells that are not "self"
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plasma cells
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secrete antibodies
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memory B cells
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bind to antigen-presenting cells to begin the process of co-stimulation
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cytotoxic T cells
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capable of mounting a rapid attack against the same antigen in secondary immune responses
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IgG
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most abundant antibody found in the plasma
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IgA
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levels greatly elevated during severe allergic responses
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IgM
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large antibody released by plasma cells in a primary response
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IgE
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found in body secretions such as milk, saliva, and sweat
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active natural
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immunity gained from being exposed to the pathogen and developing the illness
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active artificial
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immunity gained through injections of dead or attenuated strains of the disease-causing agents
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passive natural
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immunity gained from transport of antibodies across the placental membrane or through the mother's milk
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passive artificial
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immunity gained from injections of clonal antibodies to fight off a current pathogen invasion
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multiple sclerosis
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disease that destroys the myelin sheaths of the brain and spinal cord
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Graves' disease
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thyroid gland becomes hyperactive
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rheumatoid arthritis
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disease that destroys the linings of joints
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myasthenia gravis
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disease that impairs communication between nerves and skeletal muscles
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innate
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barrier and chemical defenses
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adaptive
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defenses we gain through life experiences and exposure to antigens
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pathogens
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harmful microorganisms
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complement
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system of proteins that lyses cell membranes
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immunoglobulins
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proteins that attach to antigen