chapter 14 mastering – Flashcards
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Certain traits that allow pathogens to create infection and cause disease are termed
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virulence factors.
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Which of the following enzymes breaks down the "glue" that holds cells together?
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Hyaluronidase
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Which of the following virulence factors would be found in Staphylococcus aureus?
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Staphylokinase
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How do fibrinolysins enhance a pathogen's virulence?
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They break down fibrin proteins that are involved in clot formation, allowing the cells to penetrate deep into damaged skin.
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What are leukocidins?
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Molecules that are capable of destroying phagocytes
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Measles viruses are capable of inactivating host defenses by
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suppressing the immune system.
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Meningitis and gonorrhea are caused by
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Neisseria species.
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How do superantigens enable pathogens to hide from the immune system if they actually stimulate the immune system?
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They cause the immune system to produce an exaggerated response, distracting it from the actual pathogen.
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How can capsules enable bacteria to evade the immune system?
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Capsules block the complement biding sites on the surface of the pathogen.
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How are immune cells able to detect foreign pathogens?
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They are able to detect structures on the surfaces of foreign cells that are not found in the host.
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How does a capsule help certain bacteria evade detection by the immune system?
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The capsule is composed of polysaccharides that are similar to those found in the host; thus, the immune system does not recognize it as foreign.
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Which of the following microorganisms actually grows inside the macrophage?
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Tuberculosis bacterium
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How does the protozoan Trypanosoma evade detection by the immune system?
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It can change the surface antigens frequently, preventing the immune system from tracking it.
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An exotoxin that has the ability to kill or damage host cells is referred to as a(n)
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cytotoxin.
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Which domain of the A-B toxin binds to cell surface receptors on the host cell?
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B domain
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How are superantigens different from other types of exotoxins?
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Superantigens cause an overstimulation of the host immune system.
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A person who attended a picnic early in the day develops a very high fever and is unresponsive by the evening. This person most likely has been exposed to a(n)
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superantigen.
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A patient who has been hospitalized with uncontrolled muscle spasms has probably been infected with bacteria that secrete a(n)
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neurotoxin.
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Which of the following features of Salmonella prevent it from being phagocytosed?
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Flagella
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Where do Salmonella pathogens grow and replicate in the infected host?
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Inside phagocytes
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Where is the site of Shigella attachment in the host?
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M cells
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How do Shigella cells move between host cells?
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They can polymerize actin molecules from the epithelial cells into tail-like structures that propel them from one cell to another.
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What is the etiologic agent of typhoid?
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Salmonella
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Endotoxins are also known as
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Lipid A.
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When would endotoxins be released from a bacterial cell?
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When the cell dies
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Which of the following would be the first sign of an infection that resulted in the release of endotoxin?
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Fever
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Why is a release of endotoxin into the bloodstream potentially deadly?
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It can lower blood pressure and cause the patient to go into shock.
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Which of the following would be considered a fomite?
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An infected toy
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Which of the following would be considered a vector?
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A fly carrying disease from fecal matter to food
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When aerosols containing pathogens spread disease from a distance of less than one meter, it is considered
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contact transmission.
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Which of the following is considered a major category of transmission of disease?
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Contact, vehicle, and vector transmission
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Which is an example of vehicle disease transmission?
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The presence of Listeria on undercooked chicken served for dinner
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Epidemiology is defined as the study of
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where and when a disease occurs, and how it is transmitted.
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What is the role of epidemiology?
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To learn how to treat and prevent various diseases.
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Expected prevalence of a disease is
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the expected occurrence of a disease based on past observations.
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In the sixth segment of the animation, why is the disease epidemic in North America?
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The disease occurs at a higher rate than what would normally be expected in this region.
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In the last segment of the animation, how many regions of the world experience the pandemic during April of year four?
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Five
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In the last segment of the animation, when does the first epidemic occur?
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January of year three
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If a disease occurs at a fairly stable rate, it is said to be
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endemic.
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A mutation of which of the following structures would most likely render a pathogenic bacterium avirulent?
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Fimbria
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What differentiates droplet transmission from airborne transmission?
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The distance the pathogens travel
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Which of the following describes the typical relationship between the resident microbiota and the transient microbiota?
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antagonism
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The fungus Pneumocystis jiroveci is found in the lungs of most people in low numbers, but in immunocompromised people it overgrows, resulting in severe respiratory problems. The fungus is best described as
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both resident microbiota and opportunistic pathogen.
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Axenic systems of the body include
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the kidneys.
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Which of the following situations might cause normal microbiota to become opportunistic pathogens?
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treatment of a cancer patient with radiation
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Which of the following is considered part of the indigenous microbiota of the female reproductive system?
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both Candida and Lactobacillus
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A pathogen is best described as
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any microorganism that causes disease.
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Opportunistic microorganisms are
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microorganisms that may cause a disease under certain circumstances.
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The condition called parasitism is characterized as
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a relationship between two organisms where one member harms the other.
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An axenic environment is one
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that is free of microbes.
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Normal microbiota may cause disease if they are introduced into an unusual site in the body.
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True
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In the early years of microbiology, scientists often removed disease material from one patient and introduced it into other individuals in an effort to understand what caused the disease. According to Koch's postulates, what was the major flaw in their experimental process?
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They did not isolate pure cultures of the suspected infectious agent.
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Why did the 19th century conclusion that Haemophilus influenzae causes influenza contradict Koch's postulates?
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Some flu victims had no H. influenzae in their lungs.
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Which of the following is NOT an example of a zoonosis?
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typhoid fever
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A reservoir is
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a source of microbial contamination.
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All of the following might lead to a disease caused by an opportunistic pathogen EXCEPT __________.
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an encounter with an infected animal
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Human normal microbiota begin to develop __________.
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during birth
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The typical relationship between the resident microbiota and the transient microbiota is which of the following?
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antagonism
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How was this carrier identified?
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urine culture
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Based on the data supplied, what was the approximate mortality rate for this outbreak?
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14%
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What is the reservoir for this disease organism, Salmonella enterica serotype Typhi?
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humans
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How could this epidemic be stopped without firing the worker?
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Educate the worker about personal hygiene and use of an outhouse or designated bathroom. Instruct him to thoroughly wash his hands with clean soap and water after using the facilities.
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What are the clinical signs and symptoms of typhoid fever?
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fever and rose-spotted rash
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Rabies is an example of a zoonosis that is hard to control because __________.
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its reservoir contains both domestic and sylvatic animals
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What is the standard for tuberculosis surveillance in a hospital?
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Mantoux skin test required annually
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Which vaccination may cause a false positive skin test for tuberculosis?
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BCG vaccine
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This nurse's condition worsened after medical treatment. Which specific medication is immunosuppressive?
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aerosol corticosteroids
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Why must the physicians wait three months to skin test the babies and their mothers?
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Mycobacterium tuberculosis is a slow-growing organism, and it takes the body time to mount a cell-mediated defense that can be detected by the skin test.
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Which of the following was the defining test that determined that this nurse has an active case of tuberculosis?
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the presence of acid-fast bacilli in the sputum sample
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Which of the following is the most effective way to reduce the number of healthcare associated infections (HAIs)?
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handwashing
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According to the animation, surgical infections account for what percentage of nosocomial infections?
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20%
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What type of nosocomial infection is likely to arise from intravenous catheterizations?
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Bacteremia
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How might a patient who is not being treated with an antibiotic still be exposed to an antibiotic?
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Antibiotics can be used in aerosols, thereby entering the environment.
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Why are invasive procedures likely to increase the risk of nosocomial infections?
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These procedures allow microbes from the skin to enter the bloodstream of the patient.
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How can health care workers reduce the occurrence of nosocomial infections?
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Practice more stringent aseptic techniques