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Home Page Flashcards Arecoline hydrobromide C8H14BrNO2 structure - Flashcards

Arecoline hydrobromide C8H14BrNO2 structure – Flashcards

Flashcard maker : Robert Lollar

Molecular Formula C8H14BrNO2
Average mass 236.106 Da
Density
Boiling Point
Flash Point
Molar Refractivity
Polarizability
Surface Tension
Molar Volume
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Predicted – Mcule
  • Experimental Physico-chemical Properties

    • Experimental Melting Point:

      171-176 °C SynQuest
      172 °C TCI A0523
      171-176 °C SynQuest 62335, 4H56-9-Z4
      176 °C Biosynth Q-100382

    • Experimental Boiling Point:

      209 °C Biosynth Q-100382

    • Experimental Flash Point:

      81.1 °C Biosynth Q-100382

    • Experimental Gravity:

      81.1 g/mL Biosynth Q-100382

    • Experimental Solubility:

      10 mM in DMSO MedChem Express HY-B0489
      DMSO 47 mg/mL; Water 47 mg/mL MedChem Express http://www.medchemexpress.com/Hygromycin-B.html, HY-B0489
  • Predicted Physico-chemical Properties

    • Predicted Melting Point:

      172 °C TCI
      172 °C TCI A0523
  • Miscellaneous

    • Appearance:

      Not Available Novochemy
      [NC-35688]

    • Safety:

      20/21/22 Novochemy
      [NC-35688]
      20/21/36/37/39 Novochemy
      [NC-35688]
      GHS07 Biosynth Q-100382
      GHS07; GHS09 Novochemy
      [NC-35688]
      H302 Biosynth Q-100382
      H332; H403 Novochemy
      [NC-35688]
      IRRITANT Matrix Scientific 083401
      P102; P210; P262; P270; P302+P352; P308+P313 Novochemy
      [NC-35688]
      P301+P312; P330 Biosynth Q-100382
      R52/53 Novochemy
      [NC-35688]
      Toxic/Light Sensitive/Store under Argon SynQuest 4H56-9-Z4, 62335
      Warning Biosynth Q-100382
      Warning Novochemy
      [NC-35688]

    • Target Organs:

      AChR antagonist TargetMol T2198

    • Compound Source:

      betel nuts (Arica catechu) Microsource
      [01500680]

    • Bio Activity:

      Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. MedChem Express http://www.medchemexpress.com/Hygromycin-B.html, HY-B0489
      Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. ;Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membrane of neurons of the locus coeruleus [2]. Arecoline (1 nM – 1 microM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 microM) abolished the arecoline (80 nM)–induced contraction. M3 receptor antagonist, 4 – DAMP (0.4 microM), abolished the arecoline (80 nM)–related response, whereas M2 receptor antagonist, gallamine (0.4 microM), did not affect the effect of arecoline. These results suggest that arecoline excites MedChem Express HY-B0489
      GPCR/G protein MedChem Express HY-B0489
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0489
      mAChR MedChem Express HY-B0489
      Muscarinic AChR TargetMol T2198
      Neuroscience TargetMol T2198

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

No predicted properties have been calculated for this compound.

Density:
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
Molar Refractivity:
#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:
ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
Polarizability:
Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

  • 1-Click Docking
  • 1-Click Scaffold Hop

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