antiviral agents – Flashcards
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| fusion inhibitor |
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| docosanol |
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| docosanol use |
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| active against lipid enveloped viruses topical cream for herpes in immunocompetent pts |
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| docosanol moa |
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| interferes with virl fusion to host cell membrane |
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| uncoating inhibitor |
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| rimantidine |
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| rimantadine use |
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| treatment of influenza A virus infections must be taken quickly after onset of symptoms |
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| rimantadine moa |
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| blocks M2 H+ channel and prevents virus membrane uncoating |
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| inhibitors of reverse transcriptase |
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| AZT 3TC entecavir nevirapine and efavirenz |
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| AZT use |
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| used in combo to treat HIV infection |
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| AZT moa |
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| gets incorporated into viral DNA cannot be added on to terminates viral DNA |
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| AZT stands for |
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| azidothymidine |
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| AZT replaces which base? |
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| thymine |
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| 3TC stands for |
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| 3-thiocytidine |
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| 3TC replaces ___ base |
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| cytidine |
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| 3TC use |
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| in combo with other anti-HIV drugs |
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| 3TC moa |
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| incorporated into viral DNA then terminates chain |
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| non-nucleoside Reverse transcriptase inhibitors |
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| nevirapine efavirenz |
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| nevirapine and efavirenz use |
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| combo with other anti-HIV drugs only against HIV-1, not effective against HIV-2 |
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| nevirapine and efavirenz moa |
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| inhibition of reverse transcriptase by binding to non-active site and causing structural change |
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| nevirapine and efavirenz resistance |
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| common must be used with other drugs |
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| integrase inhibitor |
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| raltegravir |
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| raltegravir use |
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| for protease inhibitor HIV resistant strains |
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| raltegravir moa |
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| inhibits catalytic activity of HIV-1 integrase stops provirus formation |
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| inhibitor of viral dna-dependent dna polymerase |
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| acyclovir |
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| acyclovir use |
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| anti herpes agent |
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| acyclovir moa |
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| incorporated into viral dna and terminates chain |
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| inhibitor of viral rna-dependent rna polymerase |
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| ribavarin |
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| ribavarin use |
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| used with interferon to treat hep c |
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| ribavirin moa |
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| causes abundant lethal mutations to viral dna |
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| inhibitor of viral protein synthesis |
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| interferon |
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| interferon use |
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| treating chronic hep b and c |
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| interferon moa |
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| stimulating degradation of ssrna and inactivation of protein synthesis machinery |
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| inhibitors of viral assembly - hiv protease inhibitors |
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| indinavir nelfinavir atazanzvir saquinavir ritonavir |
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| HIV protease inhibitors use |
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| combo therapy anti-hiv |
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| hiv protease inhibitor moa |
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| bind to active site of protease resulting in inhibition of viral assembly formed viruses are noninfective |
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| viral release inhibitors |
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| oseltamivir zanamivir |
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| oseltamivir and zanamivir use |
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| influenze a and b treatment and prophylaxis |
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| oseltamivir and zanamivir moa |
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| blocks releasing mechanism of virion during budding |
