antifungal agents – Flashcards
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| echinocandin agents moa |
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| inhibition of transmembrane glucan synthase complex cell wall looses integrity and cell lyses |
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| pore forming agents |
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| amphotericin b nystatin |
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| ergasterol synthesis inhibitors |
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| azole derivatives miconazole fluconazole |
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| amphotericin b use |
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| broad spectrum invasive infections |
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| amphotericin b moa |
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| binds to ergasterol in fungal cell and causes a pore loss of ions and other molecules is fatal |
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| nystatin use |
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| topical mucocutaneous candidiasis |
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| nystatin moa |
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| binds to ergasterol in fungal cell membranes and forms pore loss of ions and molecules lethal to cell |
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| ergasterol synthesis ihibitors azole derivatives |
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| miconazole ketoconazole fluconazole |
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| ergasterol synthesis inhibitor allylamine |
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| terbinafine |
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| allylamines use |
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| anti-dermatrophytic agent |
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| allylamies moa |
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| blocks ergasterol synthesis inhibits formation of ergosterol precursor |
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| azole two chemical classes |
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| imidazoles (two Nitrogens in ring) triazoles (three nitrogens in ring) |
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| azole derivative use |
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| broad spectrum anit-fungal |
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| azole derivative moa |
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| blocks ergasterol synthesis |
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| miconazole use |
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| vaginal infections due to candida albicans several fungal infections of skin |
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| ketoconazole use |
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| chronic mucocutaneous fungal infections 6-12 months therapy |
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| fluconazole use |
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| candidiasis |
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| inhibitor of THFA synthesis |
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| sulfa/tmp |
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| sulfa/tmp use |
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| treatment and prophylaxis of PCP (pneumocystis pneumonia) |
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| sulf/tmp moa |
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| inhibits THFA synthesis and enzymes needed for purine synthesis stops DNA and RNA synthesis |
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