Therapeutics test 1 drugs Flashcard

Hydrochlorothiazide
thiazide diuretic
chlorthalidone
thiazide diuretic
Indapamide
thiazide diuretic
metolazone
thiazide diuretic
furosemide
loop diuretic
bumetanide
loop diuretic
torsemide
loop diuretic
ethacrynic acid
loop diuretic
amiloride
potassium sparing diuretic
triamterene
potassium sparing diuretic
spironolactone
potassium sparing diuretic
glycerol
osmotic diuretic
mannitol
osmotic diuretic
acetazolamide
carbonic anhydrase inhibitor- diuretic
propranolol
non selective Beta blocker
Timolol
non selective beta blocker
nadolol
non selective beta blocker
metoprolol
selective b1 blocker
atenolol
selective b1 blocker
bisoprolol
selective b1 blocker
betaxolol
selective b1 blocker
acebutolol
selective beta1 blocker with ISA (agonistic effect for mostly b1)
penbutolol
non selective beta blocker with ISA
pindolol
non selective beta blocker with ISA (greater partial agonist for B2 than B1)
carvedilol
non selective beta blocker and selective a1 blocker
labetalol
non selective beta blocker with partial agonistic activity for B2 and selective a1 block
nebivolol
selective beta1 blocker with NO vasodilating effect
captopril
ACE- inhibitor (sulfhydryl containing)
fosinopril
ACE inhibitor (phosphonate-containing)
Enalapril (enalaprilat), benazepril, lisinopril and quinapril
ACE inhibitors (dicarboxylate containing)
Losartan, Candesartan, irbesartan, valsartan, telmisartan, eprosartan
Angiotensin 2 receptor blockers (ARBs)
Aliskiren
Renin inhibitor
Verapamil
non-dihydropyridine L-type calcium channel blocker
Diltiazem
non-dihydropyridine L-type calcium channel blocker
Nifedipine
Dihydropyridine L-type calcium channel blocker
Amlodipine
Dihydropyridine L-type calcium channel blocker
felodipine
Dihydropyridine L-type calcium channel blocker
hydralazine
Vasodilator
Minoxidil
Vasodilator
Nitroprusside
vasodilator
methyldopa
centrally acting a2 agonist
clonidine
centrally acting a2 agonist (diagnoses phenochromocytoma)
guanabenz
centrally acting a2 agonist
guanfacine
centrally acting a2 agonist
guanadrel
adrenergic neuron blocker
guanethidine
adrenergic neuron blocker
metyrosine
tyrosine hydroxylase inhibitor (inhibits synthesis of NE)interferes with sympathetic neuron function
reserpine
inhibits storage of catecholamines into vesicles interferes with sympathetic neuron function
prazosin
selective a1 blocker
terazosin
selective a1 blocker
doxazosin
selective a1 blocker
phenoxybenzamine
non selective a blocker
phentolamine
non selective a blocker
treprostinil
new anti htn agent, prostacyclin analogue
tadalafil
new htn agent, pde inhibitor
Thiazide MOA
inhibits na+/cl- pump on luminal side of DCT (short term: dec CO by dec blood volume) long term: dec sodium in SM= dec sensitivity to vasopressors= dec PVR= dec BP)
Loop Diuretics MOA
inhibit Na+/Cl-/K+ cotrans on apical side of TAL. (dec BV= dec preload= dec. SV= dec CO= dec BP).

also stimulates renin release by blocking TGF by blocking sodium from entering macula densa

Potassium sparing diuretics (spironolactone) MOA
blocks the binding of aldosterone in the collecting duct which decreases sodium and increases K+ and H+
K+ sparing diuretics (amiloride and triamterene)
blocks na+ channel on apical side of late DCT
Osmotic diuretics MOA
increases osmotic pressure of plasma, (mannitol not reabs), reduces conc. grad of sodium which decreases reabs of sodium.
Carbonic anhydrase inhib MOA
inhibits reabs of sodium bicarb. acts at PCT. increases acidity of blood
non-selective beta blockers MOA
blocks NE effects by binding to b1 and b2 receptors (decreases contractility=dec SV= dec CO= dec BP) (dec HR= dec CO= dec BP) BLOCK RENIN RELEASE (inhib Gs in Juxt cells which dec Camp and dec renin release) at first inc PVR but in long term dec.
selective b blockers MOA
more affinity for B1 than B2. (block NE action, dec CAMP= dec ca levels= dec contractility= dec CO= dec HR) DECREASE HR and CONTRACTILITY. BLOCK RENIN RELEASE
Beta blockers w/ ISA MOA
less likely to cause lowered HR and cold extremeties. Decreases CO but doesn’t lower contractility or HR as much b/c ISA calms those effects
combined a and b blockers MOA
blocking a 1 receptor= vasodilation
dec HR and contractility (B1 block) dec PVR ( a1 block)
B blocker w/ NO vasodilating MOA
causes release of NO by binding to B 3 recep on vasculature
ACE inhib MOA
inhib ACE conversion of Ang 1 to Ang 2 therefore inhibiting Angiotensin 2 action (vasoconstrictor) causing vasodilation. and blocks aldosterone (dec BP) Dec arteriole and venous pressure, dec sodium inc. in potassium and dec cardiac afterload= inc CO (compensatory)
ARB MOA
block angiotensin 2 AT1 receptors
– relax SM= vasodilation= inc H2o and sodium excretion= dec in BV
REnin inhib
block angiotension conversion to ang 1
non-dihydropyridine cach block MOA
blocks ca channels in heart and vasculature (sM)
dihydropyridine MOA
block ca channels in BV causing vasodilation on arteriol side dec hr and contractility
Hydralazine MOA
relaxes arteriolar SM (dec SVR= dec BP)
Minoxidil MOA
PRODRUG

activates Katpase channel so lets K+ out of cell to relax

nitroprusside MOA
releases NO which vasodilates (inc cgmp dec SVR dec BP
Centrally acting alpha 2 agonists MOA
bind to a 2 receptor which increase PNS outflow and inc vagal outflow which dec. arteriole and venous tone
adrenergic neuron blocker MOA
drug taken up into neuron by uptake 1 (at postganglionic presynaptic nerve terminal) and replaces NE in vessicles and lets it be eaten up by MAO
metyrosine MOA
block production of NE by stoping tyrosine hydroxylase dec NE dec BP
reserpine MOA
block packagine of NE, DA and seritonin into secretory vesicles and lets it leak into cytosol and be eaten by MAO
selective alpha 1 blockers MOA
block alpha 1 postsynaptically which inhibits vasoconstriction lowering BP. reduce arteriole tone/resistance and dilates venous side (dec CO)
non-selective alpha blockers
a1 in postsyn cell membrane and a2 in presyn nerve terminal. dec PVR and dec BP. venodilators!!!

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