Telomeres and cancer – Flashcards
8 test answers
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What happens once telomeres are shortened to a certain minimal threshold?
answer
End to end chromosome fusion occurs
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What happens when end to end chromosome fusion occurs?
answer
Apoptosis or proliferative arrest
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question
How do tumors survive so many cell divisions without shortening of their telomeres?
answer
They have activated telomerase which maintain normal telomere length
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question
Where is telomerase normally located?
answer
This enzyme is usually present in germ cells only
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