Step 1 First Aid 2017 – HLA Associations

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HLA-A3
answer

Hemochromatosis “HA3mochromatosis”
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HLA-B8
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1) Addison 2) Myasthenia Gravis 3) Graves disease “Gr8vis and Gr8ves”
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HLA-B27
answer

Seronegative arthropathies(no rheumatoid factor in serum) a) *P*soriastic arthritis b) *A*nkylosing spondylitis c) *I*nflammatory bowel disease d) *R*eactive arthritis(Reiter syndrome) *PAIR* “*B*uy *27 PAIRs* of pants”
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HLA-DR2
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1) Goodpasture’s syndrome 2) Hay fever 3) SLE(Lupus) 4) Multiple sclerosis “2 word dz” G-H & L-M “2-3 SLE”
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HLA-DR3
answer

1) Diabetes Mellitus type I, SLE, Graves disease, Addison “Gr3y”=Graves “2-3 SLE”
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HLA-DR4
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1) Rheumatoid arthritis(RAv-4) 2) DM I 3) Addison disease
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HLA-DR5
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1) Pernicious Anemia ->vitamin B12 def. 2) Hashimoto’s thyroiditis
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HLA-DQ2/DQ8
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*Celiac disease*. “Ate (*8*) Too (*2*) much *gluten* at *D*airy *Q*ueen”

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