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Home Page Flashcards Sildenafil citrate C28H38N6O11S structure - Flashcards

Sildenafil citrate C28H38N6O11S structure – Flashcards

Flashcard maker : James Hopper

Molecular Formula C28H38N6O11S
Average mass 666.700 Da
Density
Boiling Point
Flash Point
Molar Refractivity
Polarizability
Surface Tension
Molar Volume
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Experimental Physico-chemical Properties

    • Experimental Melting Point:

      186-188 °C LabNetwork LN01302765

    • Experimental Solubility:

      DMSO 23 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL MedChem Express HY-15025A
      DMSO:50 mg/ml;ethanol:50 mg/ml;DMF:20 mg/ml; MedChem Express HY-15025A
      Soluble in DMSO Axon Medchem 2046
      Soluble to 100 mM in DMSO Tocris Bioscience 3784
  • Miscellaneous

    • Appearance:

      White to off-white powder Chemodex S0078

    • Safety:

      5 Axon Medchem 2046
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 2046
      no pictogram Axon Medchem 2046
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 2046
      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3784
      Warning Axon Medchem 2046
      Xi Abblis Chemicals AB1009362

    • Target Organs:

      PDE inhibitor TargetMol T0467

    • Bio Activity:

      Enzymes Tocris Bioscience 3784
      Metabolic Enzyme/Protease; MedChem Express HY-15025A
      Metabolism TargetMol T0467
      Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Tocris Bioscience 3784
      Orally active, potent PDE5 inhibitor Tocris Bioscience 3784
      Others MedChem Express HY-15025A
      PDE MedChem Express HY-15025A
      PDE5, PDE6 TargetMol T0467
      Phosphodiesterases Tocris Bioscience 3784
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. MedChem Express
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.; IC50 Value: 5.22 nM [1]; Target: PDE 5; in vitro: Pretreatment with 1 umol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P < 0.05) [2]. MedChem Express HY-15025A
      Sildenafil citrate, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction.;IC50 Value: 5.22 nM [1];Target: PDE 5;In vitro: Pretreatment with 1 umol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone (P < 0.05) [2]. pretreatment of cells with sildenafilsuppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs [4].;In vivo: Sildenafil at a dose ranging from 10 to 40mg/kg statistically increased psychomotor seizure threshold in mice. Moreover, sildenafil enhanced the anticonvulsant action of all the studied AEDs in this test [3]. Administration of oral sildenafil MedChem Express HY-15025A

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

No predicted properties have been calculated for this compound.

Density:
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
Molar Refractivity:
#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:
ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
Polarizability:
Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

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