S6: Lung cancer (Wiki) – Flashcards
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Respiratory symptoms
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Coughing , wheezing(+haemoptosis), shortness of breath.
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Systemic symptoms
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Weightloss, weakness, fever, clubbing.
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Non-smoking causes
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Genetic predisposition, asbestosis, air pollution, radon gas.
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Diagnosis
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Chest imaging, usually CT scanning. Histology/biopsy.
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Classifications (of carcinomas) (2)
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Non-small-cell lung carcinoma and small-cell carcinoma
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Treatment
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Surgery, radiotherapy (creates radicals, oxidative dna damage), chemotherapy.
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SCLC
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Extremely rapid progression/highly metastatic. Arises in peribronchial locations. (Oat cell, more rare)
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3 types of NSCLC
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Adenocarcinoma, squamous cell carcinoma, large-cell carcinoma
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Adinocarcinoma
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Malignant tumours in glandular structures in epithelium.
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Squamous-cell carcinoma
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Malignant carcinoma of squamous epithelium lining alveoli.
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Large-cell carcinoma
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Heterogenous group of undifferentiated malignant neoplasms that lack features of small cell or other non-small cell malignancies.
