NIM: cancer, molecular mechanisms – Flashcards
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nitrite cured foods w/ regular fruit/veg intake--mechanism
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ascorbic acid in freshies inhibits nitrosamine formation in stomach
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52 yo w/ cancerous polyp, diet & future CA risk
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freshies slow accumulation of DNA mutations
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antioxidant defenses for free radical damage in cytosol
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superoxide dismutase
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phase 1 enzyme rxns
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hydroxylation of nitrosamines
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elderly man, smoked fish
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hydroxylation of polycyclics....phase 1 enzymes incr DNA adduct formation
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most important dietary polycyclic aromatic hydrocarbons
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charbroiled pork chop
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DNA from colon CA 67 yo vegetarian
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CA from one specific cell w/ p53 mutation
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colon carcinoma 44 yo
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adenoma & carcinoma from same precursor cell
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single hydroxyl free radical, membrane changes
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several membrane phospholipids oxidized
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aflatoxins from molds, mechanism of CA risk
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form DNA adducts in exposed tissue
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activities enhanced by phase 2 enzyme activators
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benzpyrene glucuronidation
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essential cofactor of vit E
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ascorbate
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middle aged smoker, broccoli & cheese
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broccoli promotes conjugation of carcinogens
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young man, burgers
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compounds, DNA incr mutation risk
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37 yo chain smoker, excess vit E
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in combination w/ ...incr free radicals
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several colon polyps, incr risk of CA
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w/ oncogene mutation...generate cancerous cell
