NIM: cancer, molecular mechanisms – Flashcards
Unlock all answers in this set
Unlock answersquestion
nitrite cured foods w/ regular fruit/veg intake--mechanism
answer
ascorbic acid in freshies inhibits nitrosamine formation in stomach
question
52 yo w/ cancerous polyp, diet & future CA risk
answer
freshies slow accumulation of DNA mutations
question
antioxidant defenses for free radical damage in cytosol
answer
superoxide dismutase
question
phase 1 enzyme rxns
answer
hydroxylation of nitrosamines
question
elderly man, smoked fish
answer
hydroxylation of polycyclics....phase 1 enzymes incr DNA adduct formation
question
most important dietary polycyclic aromatic hydrocarbons
answer
charbroiled pork chop
question
DNA from colon CA 67 yo vegetarian
answer
CA from one specific cell w/ p53 mutation
question
colon carcinoma 44 yo
answer
adenoma & carcinoma from same precursor cell
question
single hydroxyl free radical, membrane changes
answer
several membrane phospholipids oxidized
question
aflatoxins from molds, mechanism of CA risk
answer
form DNA adducts in exposed tissue
question
activities enhanced by phase 2 enzyme activators
answer
benzpyrene glucuronidation
question
essential cofactor of vit E
answer
ascorbate
question
middle aged smoker, broccoli & cheese
answer
broccoli promotes conjugation of carcinogens
question
young man, burgers
answer
compounds, DNA incr mutation risk
question
37 yo chain smoker, excess vit E
answer
in combination w/ ...incr free radicals
question
several colon polyps, incr risk of CA
answer
w/ oncogene mutation...generate cancerous cell