Final – 1168 words – Flashcard
Flashcard maker : Alexander Barker
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Transduction
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Transfer of bacterial genetic info using bacteriophage.
Generalized and specialized
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Transposition
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insertion of genetic information into genome
may carry additional info disrupt normal gene or insert new info
may carry additional info disrupt normal gene or insert new info
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Intracellular bacterial infection
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Th1 mediated DTH, CTLs and ADCC
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Extracellular bacterial infection
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Th2 ab mediated response;opsonization, C’, ADCC
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Innate response to Bacteria
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Inflamation – phagocytic cells, C’Mac lysis if unencapsulated Gram -/ cell wall-less
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Id Ag specific T cells
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MHC class I tetramers;bound to biotinylated avidin
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Cytotoxicity Assay
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51Cr release assay; 51Cr added to infected target cell lysed? by CD8;measure release –> effective killing?
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Microtoxicity assay
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Trypan blue test;Anti-HLA for MHCI;
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TGF-beta
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secreted by platelets, macrophages, lymphocytes and mast cells. Fxn: stimulate epithelial and mesenchymal growth. Downregulates proinflamatory activities. Induces IgA class switching
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IL-1
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Secreted by mono, macro, dendritic, endothelial, B and other •major role in the development of innate response
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ТIL-2
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Secreted by activated T cells
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IL-3
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Secreted by T cells, NK cells, eosinophils and mast cells
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IL-4
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Secreted by T cells, NK cells and mast cells– Regulates some stages of hematopoiesis
