FDNS4100 Test 3 Old Test Questions – Flashcards

d. Flushing Symptoms include - dermatitis - dementia - diarrhea - death

a. The parietal cells in the stomach secrete intrinsic factor Cubulin is associated with VitB12 absorption. Must have Ca2+ present to bind.

a. Thiaminases Thiaminases are bacterial and may cause Chastak paralysis (cook fish before eating) Hydroxyphenols are also antagonists

FALSE The Dietrich Pathway does that! Preiss-Handler Pathway: NAD de novo pathway Tryptophan --> NAD Nicotinic acid --> NAD

d. Methylene tetrahydrofolate reductase

b. Thiamin diphosphate

FALSE RBCs are used for this becuase they have higher folate levels than plasma

Folate accumulates in the form of 5'-methyl THF, because the activity of methionine synthase is reduced. Megaloblastic anemia results, since the vital coenzyme, THF, is not available for use in the thymidylate or purine cycles.

c. Cardiac hypertrophy

TRUE

b. Milk eggs, meats, green veggies, and enriched grains are also good sources

a. pyruvate --> acetyl CoA b. α-ketoglutarate --> succinate c. ribose 5-P + xyulose 5-P --> sedoheptulose 7-P + glyceraldehyde 3-P d. ALL OF THE ABOVE

c. Achlorohydra can prevent cobalamin and animal protein from separating, rendering cobalamin unable to bind to intrinsic factor to be absorbed

d. Decreased; Increased

a. Albumin

c. SLC19A2 This transporter is expressed in the early portions of the GI tract Mutations in SLC19A2 causes Rogers syndrome SLC19A3 is also a high affinity transporter - these are inhibited by alcohol

b. It participates in one-carbon metabolism Functions of Niacin include: - oxidation/reduction reactions - catabolic reactions - biosynthetic reactions - posttranslational modification of proteins (ADP-ribosylation)

a. Use of defined diets b. Recognition that certain diseases are related to diet c. Development of appropriate animal models d. ALL OF THE ABOVE

d. Catalyzes decarboxylation reactions Functions of Riboflavin include: - oxidation/reduction reactions - energy production via respiratory chain - protect cells from oxidative stress

TRUE 5'deoxyadenosylcobalamin (AdoCbl) is the major form in the liver

b. Impairing tryptophan absorption Also affects niacin synthesis, and can lead to pellagra

c. Dementia Clinical symptoms of Riboflavin Deficiency include: - Seborrheic dermatitis - Cheilosis - Glossitis - Burning, itching eyes

b. Propionyl CoA is in equilibrium with propionyl carnitine; the increase in propionyl CoA results in increased excretion of carnitine in the urine as propionyl carnitine.

a. It is the ilial intrinsic factor receptor b. It recognizes the intrinsic factor-B12 complex c. It uptakes the vitamin complex through receptor-mediated endocytosis d. ALL OF THE ABOVE ARE TRUE

b. methylmalonyl CoA reductase

c. Plamsa FAD Proper indicators include: - Erythrocyte gluathione reductase - Erythrocyte flavin - Urinary excretion of riboflavin

d. A coenzyme for an enzyme catalyzing reactions that produce NADPH in the pentose phosphate pathway Functions also include: Catalyze oxidative decarboxylation - pyruvate --> acetyl CoA - alpha-ketoglutarate --> succinyl CoA Thiamin Triphosphate

a. Germ Theory

a. Megaloblastic anemia b. Peripheral neuropathy c. Dementia d. Degeneration of the spinal cord e. ALL OF THE ABOVE

c. Oxidation/reduction reactions Functions of Choline include: - Methyl metabolism - Lipid and cholesterol transport & metabolism - Structural integrity of cell membranes - Transmembrane signaling

a. Serum methylmalonic acid Plasma homocysteine is not specific for B12, it changes with Folate & VitB6

a. Monoglutamate / polyglutamate

b. Holocarboxylase synthase deficiency Thiamin responsive genetic disorders: - Pyruvate decarboxylase deficiency - Wernicke-Korsakoff syndrome - Maple syrup urine disease

a. Consumption of 100g protein/day will meet the RDA for niacin

b. Dihydrofolate reductase; thymidylate cycle

c. Glutamates allow folate to be retained in tissues

TRUE

b. Myelomeningocele

a. Hypotension

TRUE

a. Phosphatidylethanolamine methyltransferase pathway

e. Cobalamin

d. There was an increase in serum alanine aminotransferase levels, indicating liver damage.

a. Phosphatidylethanolamine methyltransferase pathway

d. Kynurenine mono-oxygenase

c. Most of the Thiamin in the body is found in skeletal muscles

c. Folic acid in supplements (taken w/o food)

a. Acetyl CoA carboxylase

a. Acetyl CoA carboxylase; acetyl CoA malonyl CoA

Nicotinamide is synthesized in the liver from tryptophan

c. Coenzyme A

b. Marasmus The 4 were Scurvy, Rickets, Pellagra, and Beriberi

a. Niacin

c. Fruits Good sources include unrefined cereals and enriched cereals, meats, nuts, and legumes

a. A 43 year-old alcoholic man Populations at risk include - congenital heart disease - cancer - excessive alcohol intake - diabetes

b. Erythrocyte count

Thiamin --> Beriberi Niacin --> Pellagra Folate --> Neural Tube Defects VitD & Calcium --> Rickets VitC --> Scurvy VitB12 --> Megaloblastic anemia