Exam 3 Biochem-Lecture 35 – Flashcards

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Deoxyribonucleotides are formed by
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 the reduction of ribonucleoside diphosphates.
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All deoxyribonucleotides are synthesized from ........... by the enzyme ribonucleotide reductase.
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 ribonucleotides
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nAll deoxyribonucleotides are synthesized from ribonucleotides by the enzyme .......
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ribonucleotide reductase. (highly regulated)
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                   Deoxthymidylate (dTMP) is

formed by

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methylation of deoxyuridine 5’-mono Phosphate (dUMP)

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what is the precursor for all the pyrimidine nucleotides????
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UMP
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nPyrimidine nucleotides are degraded to ....?
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b-amino acids
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Nucleotide mono-, di-, and triphosphates are .......

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interconvertible

For example - UMP → UDP → UTP

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Specific nucleoside (X) monophosphate kinases make

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nucleoside diphosphates

 

XMP + ATP   -->XDP + ADP

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• A nucleoside diphosphate kinase, with broad substrate specificity,interconverts............ (this enzyme uses both ribo- and deoxynucleosides as substrates)

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dinucleosides and trinucleosides
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Nucleotide coenzymes are
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nNAD
nFAD
nCoenzyme A (CoA)
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NAD means

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nicotinamide adenine dinucleotide
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FAD means

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Flavin Adenine Dinucleotide
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nPRPP is the KEY molecule in
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¨ de novo synthesis of purine and pyrimidine nucleotides
¨salvage of purine and pyrimidine bases
¨ and synthesis of NAD+.
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PRPP means
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5-phosphoribosyl-1-pyrophosphate
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dUMP can be converted to dTMP using this enzyme:
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thymidylate synthase

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thymidylate synthase
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an enzyme targeted by anticancer drugs such as 5-flurouracil
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nThe regeneration of THF from DHF produced in the thymidylate synthase reaction requires
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dihydrofolate reductase
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dihydrofolate reductase
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an enzyme targeted by the drug, methotrexate.
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Methotrexate is
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Folic acid antagonist
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Acyclovir is analog
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purine
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AZT is a ...... analog
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pyrimidine
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nAcyclovir a purine analog, and AZT a pyrimidine analog are used in the treatment of
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HSV and HIV infections.
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Acyclovir, a purine analog, and AZT a pyrimidine analog are
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antiviral agents
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6-Mercaptopurine  is
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purine analog
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5-Fluorouracil is
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pyrimidine analog
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Cystonesine arbinoside is
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pyrimidine analog
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