|Deoxyribonucleotides are formed by|
| the reduction of ribonucleoside diphosphates.|
All deoxyribonucleotides are synthesized from ……….. by the enzyme ribonucleotide reductase.
nAll deoxyribonucleotides are synthesized from ribonucleotides by the enzyme …….
ribonucleotide reductase. (highly regulated)
Deoxthymidylate (dTMP) is
methylation of deoxyuridine 5’-mono Phosphate (dUMP)
|what is the precursor for all the pyrimidine nucleotides????|
nPyrimidine nucleotides are degraded to ….?
Nucleotide mono-, di-, and triphosphates are …….
For example – UMP → UDP → UTP
Specific nucleoside (X) monophosphate kinases make
XMP + ATP –>XDP + ADP
• A nucleoside diphosphate kinase, with broad substrate specificity,interconverts………… (this enzyme uses both ribo– and deoxynucleosides as substrates)
|dinucleosides and trinucleosides |
nCoenzyme A (CoA)
|nicotinamide adenine dinucleotide|
|Flavin Adenine Dinucleotide|
nPRPP is the KEY molecule in
¨ de novo synthesis of purine and pyrimidine nucleotides
¨salvage of purine and pyrimidine bases
¨ and synthesis of NAD+.
|dUMP can be converted to dTMP using this enzyme:|
|an enzyme targeted by anticancer drugs such as 5-flurouracil|
nThe regeneration of THF from DHF produced in the thymidylate synthase reaction requires
|an enzyme targeted by the drug, methotrexate. |
nAcyclovir a purine analog, and AZT a pyrimidine analog are used in the treatment of
|Acyclovir, a purine analog, and AZT a pyrimidine analog are|
|Cystonesine arbinoside is|