Home Page Flashcards Donepezil hydrochloride C24H30ClNO3 structure - Flashcards

Donepezil hydrochloride C24H30ClNO3 structure – Flashcards

Flashcard maker : Carmen Dawson

Contents

Experimental Flash Point:
Experimental Gravity:
Experimental Solubility:
Appearance:
Safety:
Drug Status:
Compound Source:
Bio Activity:

Molecular Formula	C₂₄H₃₀ClNO₃
Average mass	415.953 Da
Density
Boiling Point
Flash Point
Molar Refractivity
Polarizability
Surface Tension
Molar Volume

Experimental data
Predicted – ACD/Labs
Predicted – ChemAxon

Experimental Physico-chemical Properties

Experimental Flash Point:

273.1 °C Biosynth Q-201040
Experimental Gravity:

273.1 g/mL Biosynth Q-201040

Experimental Solubility:

10 mM in H2O (free soluble); MedChem Express HY-B0034

DMSO water MedChem Express http://www.medchemexpress.com/amrubicin.html, HY-B0034

Soluble in water and DMSO Axon Medchem 1438

Soluble to 75 mM in water and to 10 mM in DMSO Tocris Bioscience 4385

Soluble to 75 mM in water and to 25 mM in DMSO Tocris Bioscience 4385

Miscellaneous

Appearance:

Not Available Novochemy
[NC-08046]

Safety:

20/21/22 Novochemy
[NC-08046]

20/21/36/37/39 Novochemy
[NC-08046]

5 Axon Medchem 1438

GHS07; GHS09 Novochemy
[NC-08046]

H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1438

H304; H332 Novochemy
[NC-08046]

IRRITANT Matrix Scientific 090394

no pictogram Axon Medchem 1438

None LKT Labs
[D5753]

P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1438

P102; P210; P262; P270; P302+P352; P308+P313 Novochemy
[NC-08046]

P261; P262 Biosynth Q-201040

R22 Novochemy
[NC-08046]

Warning Novochemy
[NC-08046]

Warning Axon Medchem 1438

Drug Status:

approved BIONET-Key Organics KS-1051
Compound Source:

synthetic; E-2020, BNAG Microsource
[01504403]

Bio Activity:

AChE MedChem Express HY-B0034

Cholinesterases Tocris Bioscience 4385

Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. ;IC50 Value:;Target: AChE;It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer’s disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats. MedChem Express HY-B0034

Enzymes Tocris Bioscience 4385

Esterases Tocris Bioscience 4385

Neuronal Signaling MedChem Express HY-B0034

Neuronal Signaling; MedChem Express HY-B0034

Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active. Tocris Bioscience 4385

Potent AChE inhibitor Tocris Bioscience 4385

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

No predicted properties have been calculated for this compound.

Density:
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction:
Molar Refractivity:
#H bond acceptors:
#H bond donors:
#Freely Rotating Bonds:
#Rule of 5 Violations:

ACD/LogP:
ACD/LogD (pH 5.5):
ACD/BCF (pH 5.5):
ACD/KOC (pH 5.5):
ACD/LogD (pH 7.4):
ACD/BCF (pH 7.4):
ACD/KOC (pH 7.4):
Polar Surface Area:
Polarizability:
Surface Tension:
Molar Volume:

Click to predict properties on the Chemicalize site

Donepezil hydrochloride C24H30ClNO3 structure – Flashcards

Experimental Flash Point:

Experimental Gravity:

Experimental Solubility:

Appearance:

Safety:

Drug Status:

Compound Source:

Bio Activity:

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