dermatology definition – Flashcards
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hyperkeratosis
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stratum corneum thicken Psoriasis, calluses
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parakeratosis
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hyperkeratosis with nuclei retention in stratum corneum --Psoriasis
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spongiosis
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epidermal accumulation of edematous fluid in intercellular space --Eczematous dermatitis
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acantholysis
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epidermal cell separation --pemphigus vulgaris
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acanthosis
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eidermal hyperplasia (spinosum) --acanthosis nigricans
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albinism
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defective tyrosinase defect tyrosine transport neural crest migration failure
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melasma
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mask of pregnancy
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vitiligo
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depigmentation (autoimmune)
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atopic dermatitis eczema
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flexure baby asthma, allergic rhinitis type I hypersensitivity
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allergic contact dermatitis
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type 4 hypersensitivity nickel, poison ivy
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psoriasis
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acanthosis (spinosum thicken) parakeratosis less granulosum auspitz sign
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rosacea
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inflamm facial skin, no comedones
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seborrheic keratosis
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horn cysts Leser Trelat sign
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Verrucae
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wart hyperkeratosis, koilocytosis,
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impetigo
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superficial skin infection highly contagious honey colored crusting bullous impetigo has ullae (s aureus)
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cellulitis
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deeper dermis & subcutaneous
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erysipela
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upper dermis & superficial lymphatic well defined demarcation
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abscess
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pus within deeper layer of skin
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necrotizing fasciitis
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crepitus bullae & purple skin
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staphlococcal scaled skin syndrome
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exotoxin A & B destroy keratinocyte attachment in granulosum ONLY sloughing upper layers of epidermis copletely
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toxic epidermal necrolysis
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toxin destroys epidermal - dermal junction
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pemphigus vulgaris
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IgG target desmoglein (desmosome) flaccid intraepidermal bullae by acantholysis reticular "net like" pattern nikolsky sign (+)
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bullous pemphigoid
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IgG aganist hemidesmosome "tense blister" spare oral mucosa IF "linear " pattern Nikoisky sign (-)
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dermatitis herpetiformis
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IgA deposit at dermal papillae tip ~ celiac disease
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acanthosis nigrican
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epidermal hyperplasia hyperinsuliniemia, GI adenocarcinoma
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actinic keratosis
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premalignant sun exposure
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erythema nodosum
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painful inflamm lesion of subcutaneous fat anterior shin sarcoidosis, coccidiodomycosis, histoplasmosis, TB strep, leprosy, Crohn
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lichen planus
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pruritis purple polygonal planar papule plaques Wickham striae / reticular white lines sawtooth infiltrate of lymphocyte @ dermal-epidermal junction HCV
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Pityriasis rosea
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"Herald patch" "Christmas tree pattern"
