Aromaticity: Benzene, Pyridine and Pyrrole

Flashcard maker : Lily Taylor
Oil
Coal tar distillate
Pharmaceuticals
Plastic
Four uses for benzene
Planar
Fully conjugated
Cyclic
Huckel’s Rule: Three features that a system requires to be aromatic
86kcal/mol
The energy released by benzene when being hydrogenated
Electrophilic addition
Because the product is energetically unfavourable
The type of reaction benzene is expected to undergo (like an alkene)
Why doesn’t it undergo this?
Asprin
Prozac
Daunomycin
Three examples of compounds containing aromatic structures
An anti-cancer agent
What is daunomycin?
It intercalates with DNA
Causes distortion of DNA helix
Prevents cell replication
How daunomycin works
An aromatic compound where one or more of the carbon atoms are been replaced with an atom other than carbon
What is an aromatic heterocycle?
A 6-membered aromatic heterocycle containing nitrogen
Define a pyridine
A 5-membered aromatic heterocycle containing nitrogen
Define a pyrrole

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