Amiodarone

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CLASS:
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Antidysrhythmic
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ACTION
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-Slows sinus rate, prolongs PR and QT intervals, decreases peripheral vascular resistance. -Prolongs action potential and refractory period.
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INDICATIONS:
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VTACH and VFIB
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CONTRAINDICATIONS:
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Sever sinus node dysfunction, Sinus Brady, 2nd and 3rd degree blocks
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SPECIAL CONSIDERATIONS:
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Heart Failure
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ONSET:
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Rapid/DURATION 30-45 minutes
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DOSE: ADULT:
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150 mg over 10 min flowed by 1mg/min for 6 hours
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PEDS:
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5mg/kg IV/IO mas dose 15mg/kg
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ADVERSE REACTIONS:
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Hypotension, nausea, tremors, anorexia, malaise, ventricular ectopic beats
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DRUG/FOOD TO AVOID
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St. John’s wart decreased the effect. Grapefruit juice; toxicity.
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DRUG/LAB TESTS
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T4, ALT, AST,GGT, alk phos, cholesterol, lipids, PT, INR
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NURSING CONSIDERATIONS/PT TEACHING
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I&O; monitor: electrolytes, K+ liver functions, AST, ALT, bilirubin, alkaline phosphatase, dehydration, hypovolemia. PT TEACHING: *report side effects *skin discoloration is usually reversible *dark glasses may be needed for photophobia* use sunscreen *take as prescribed, no double dosing *complete follow up appts including outpt testing.

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