Aminoglycosides/ gentamicin

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Therapeutic uses of gentamicin
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treats serious infections caused by G-, systemic UTI that started un urinary tract
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Mode of Action for gentamicin
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bactericidal; inhibition of bacterial protein synthesis, destroy MO and may cause miscoding.
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Contraindications of gentamicin
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pregos, lactation, severe renal disease, allergies to aminoglycosides, pre-existing hearing loss, myasthenia gravis/parkinsons
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Precautions of gentamicin
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renal, hepatic disease, dehydration
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Adverse Effects of gentamicin
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Serious:ototoxicity, nephrotoxicity, hepatic damage, thrombocytopenia, CNS numbness, photosensitivity, hypersensitivity, GI distress
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Interactions of gentamicin
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it will inactivate aminoglycosides when mixed in the same IV solution; when administered with other ototoxic medications- the risk increases.
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Gentamicin loves_____
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vancomycin
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Pharmacokinetics of gentamicin
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IV: onset is immediate, peaks in 1-2 hours, IM onset is rapid, peaks in 1-2 hours
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Nursing implications for gentamicin
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check hearing impairment, assess pt. nutritional status, store in frig until use

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