Helminths – Microbiology – Flashcards
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| Nematodes |
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| Round worms |
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| Cestodes |
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| tape worms (segmented) |
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| trematodes and Tx |
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| flukes (non-segmented); tx: praziquantel (all) |
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| Mode of infection for Cestodes |
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| Ingestion |
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| Tx for Cestodes |
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| albendazole, praziquantel, niclosamide |
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| Taenia Saginata |
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| Beef Tape Worm |
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| Taenea Solium |
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| Pork Tapeworm |
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| Cysticercosis and tx |
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| When humans eat taenia solium eggs, which hatch in the intestine, migrate throughout the body and encyst in the brain (causing seizures or blindness)or skeletal muscle Tx: albendazole and corticosteroids |
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| Worms seen in vitreous humor |
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| Taenia Solium |
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| Tx of T. Solium GI infx |
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| Praziquantel, niclosamide |
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| Diphyllobothrium Latum and Tx |
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| Fish tapeworm and Praziquantel |
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| Helminth that competes for B12 |
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| Diphyllobothrium Latum |
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| Echinococcus Granulosus and tx |
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| Dog Tapeworm and Albendazole followed by cyst aspiration; tx: albendazole followed by cyst aspiration |
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| Hydatid cyst dz |
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| Manifestation of Echinococcus Granulosus; can involve the liver, lungs and brain causing dysf(x) |
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| Snails are intermediate hosts |
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| Flukes |
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| Clonorchis Sinensis and tx |
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| Chinese Liver Flukes; tx: praziquantel |
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| Helminth infx from undercooked fish |
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| clonorchis sinensis and diphyllobothrium latum |
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| Helminths that mature in biliary tree |
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| clonorchis sinensis |
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| Helminth infx assoc. w/ cholangiosarcoma |
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| Clonorchis sinensis |
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| paragonimus westermani and tx |
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| Lung fluke; tx: praziquantel |
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| Helminth infx assoc. w/ hemoptysis |
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| paragonimus westermani |
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| Helminth infx from ingesting under-cooked shellfish |
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| Paragonimus westermani |
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| Schistosomes; transmission; tx |
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| Blood flukes; larvae released in to water, penetrate exposed skin and migrate to target tissues via bloodstream; Tx: praziquantel |
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| Katayama fever |
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| constitutional sx after infx by schistosomes: HA, fever, hives, weight loss and cough. |
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| swimmer's itch |
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| dermatitis after schistosome infx |
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| Helminth assoc. w/ portal HTN |
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| Schistosoma Japonicum and Schistosoma mansoni |
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| Helminth assoc. w/ intestinal polyps |
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| schistosoma japonicum and schistosoma mansoni |
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| Helminth assoc w/ UTI sx and squam cell ca of the bladder |
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| Schistosoma hematobium |
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| MC Helminth infx in the world |
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| Ascaris lumbricoides |
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| Tx for ascaris lumbricoides |
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| pyrantel pamoate, mebendazole, albendazole |
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| Helminth assoc. w/ migration to lungs -> trachea-> GIT |
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| Ascaris lumbricoides, strongyloides stercoralis, hookworms (necator americanus and ancylostoma duodenale) |
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| Helminth that causes malnutrition |
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| Ascaris lumbricoides |
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| Enterobius Vermicularis and tx |
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| Pin worms; pyrantel pamoate, mebendazole, albendazole |
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| scotch tape test |
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| dx of Enterobius Vermicularis |
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| intense peri-anal itching |
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| enterobius vermicularis |
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| Trichuris Trichuria and tx |
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| Whip Worm; Tx: mebendazole and abendazole |
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| Helminth assoc. w/ bloody diarrhea |
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| trichuris trichuria |
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| Trichinella spiralis and tx |
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| Pork roundworm; tx: mebendazole, abendazole and corticosteroids (for muscle cysts) |
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| Helminth assoc. w/ myocarditis and encephalitis |
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| Trichinella spiralis |
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| Helminth not dx w/ visualizing eggs |
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| Trichinella spiralis |
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| Dracunculus Medinensis and tx |
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| Guinea Worm; Tx: surgical removal of nodules or slowly pulling out with matchsticks |
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| Helminth tx by pulling out with stick |
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| Drancunculus Medinensis |
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| Helminth that live in crustaceans |
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| Dracuncularis medinensis |
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| Toxocaris Canis and tx |
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| Dog ascaris; tx: infx is self-limited, but steroids may help |
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| Helminth assoc. w/ dog shit |
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| Toxocaris canis |
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| Visceral Larva Migrans |
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| Toxocaris Canis |
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| Stronyiloides stercoralis and tx |
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| Threadworm; tx: ivermectin and thiabendazole Use Ivermectin to overcome strongyloides |
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| Helminth assoc. w/ autoinfection |
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| Stongyloides stercoralis |
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| Helminth assoc. w/ larvae in stool |
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| Strongyloides stercoralis |
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| Helminth that penetrates skin |
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| Strongyloides stercoralis, schistosomes, hookworms (ancylostoma duodenale, necator americanus, cat or dog hookworm) |
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| Necator Americanus |
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| New World Hook Worm |
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| Ancylostoma Duodenale |
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| Old Work Hook worm |
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| Tx for hookworm |
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| mebendazole, pyrantel pamoate, Fe and folic acid for anemia |
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| Helminth assoc. w/ microcytic anemia |
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| Hookworm |
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| Helminth that penetrates the skin, but cannot penetrate basemenet membrane |
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| Cat or dog hookworm |
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| Cutaneous larva migrans and tx |
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| Cat or dog hookworm; tx: self-limited |
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| Onchocerca Volvulus and tx |
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| River Blindness; tx: ivermectin for microfilarae only, surgery for nodules |
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| Arthropod borne Helminth |
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| Onchocera Volvulus, loa loa, wucheria bancrofti |
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| Black Fly |
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| Onchocera Volvulus |
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| Adult Helminths cannot migrate, die in skin and cause fibrotic nodules |
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| Onchocera Volvulus |
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| Loa Loa and tx |
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| Eye Worm; tx: diethylcarbamazapine |
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| Chrysops Fly |
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| Loa Loa |
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| Calabar Swellings |
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| Episodic swellings assoc. w/ loa loa infx |
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| Can be seen migrating through subconjunctiva |
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| Loa loa |
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| Wucheria Bancrofti and tx |
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| Elephantiasis; tx: diethylcarbamazapine and doxy |
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| Helminth transmitted by mosquito bite |
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| Wucheria Bancrofti |
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| Adults migrate to and fibros in lymphatics causing edema |
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| wucheria bancrofti |
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| Swelling of the genitals and lower limbs |
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| Wucheria bancrofti |
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| dx made by seeing in blood at night |
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| wucheria bancrofti |
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| Management of extraperitoneal rectal injury |
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| Primary repair or diverting colostomy to allow injury to heal |
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| Management of intraperitoneal rectal injuries |
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| Primary repair; only need to divert if the pt has severe associated injuries with significant blood loss |
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| Management of blunt kidney injury |
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| # do nothing unless injury is bilateral or if pt only has one kidney # if leaving it in situ leads to persistant hypertension, delayed nephrectomy indicated. |
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| Management of distal ureter injury |
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| # ideal: spatulate both ends and do end-to-end anastamosis over a double J stent. # if not enough length: psoas hitch to mobilze the bladder; uretero-ureterostomy; mobilize the kidney and bring into pelvis; # damage control: ligate both ends of ureter, perform nephrostomy later, and delayed repair of ureter; temporary cutaneous ureterostomy over J stent |
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| Clinically significant hemodynamic alterations in late term pregnant women to be aware of in trauma |
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| Blood volume is increased but volume is increased proportionately more which would increase the amount of blood loss required to produce hypotension and tachycardia |
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| Clinically significant phsysiologic alterations in late term pregnant women to increase O2 delivery to fetus and to be aware of in trauma |
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| # increased minute ventilation which causes mild respiratory alkalosis, but decreases mother's FRC and respiratory reserve # increased 2,3-DPG to aid in O2 offloading from hemoglobin |
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| Anatomic changes of later pregnancy to keep in mind during trauma |
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| # fetus may compress IVC, so lay mother on LLD position # more prone to aspiration from cranially displaced stomach so early NGT placement # constant stretching of peritoneum leads to desensitization making it possible that the mother will not show peritoneal signs |
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| Management of suspected bladder injury |
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| # CT cystogram if hematuria in presence of pelvic fxs # Intraperitoneal: open 3-layer repair with chromic suture and suprapubic cystostomy # Extraperitoneal: foley catheter drainage for 7-10 days |
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| Management of suspected blunt cardiac injury |
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| # Order troponin and EKG; If neg, repeat both in 8 hrs; 2 consecutive negatives rules it out. # if either EKG or trop are positive, admit for obs in a monitored bed # If unstable, stat echo to look for anatomic abnormality; if neg, invasive monitoring +/- pressor; if positive, problem is addressed |
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| Order of preference for peripher IV access in a child younger than 6 |
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| 1. AC fossa 2. cutdown on superficial saphenous vein 3. intrerosseous cannulation of proximal tibia 4. interosseous cannulation of distal femur |
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| Cattell maneuver and what vascular structures it's good for exposing |
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| # medial visceral rotation of the cecum and ascending colon; # good for exposing retropertineal structures, like the IVC and R ureter |
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| Kocher maneuver and what vascular structures it's good for exposing |
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| # mobilization and medial rotation of the duodenum # exposes the suprarenal IVC below the liver |
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| Mattox maneuver and what vascular structures its' good for exposing |
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| # medial rotation of the left colon, kidney and spleen toward the midline # combined with division of the left crus of the diaphragm and dividing the celiac plexus, can expose the celiac axis |
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| Way to expose injuries to the distal IVC and iliac vein bifurcations |
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| # division of the R CIA and primary repair |
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| Way to expose injuries to the SMA and the confluence of the portal vein |
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| # division of the neck of the pancreas |
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| Indications for operative management of penetrating or blunt injuries to thoracic structures |
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| 1. Initial hemothorax drainage of > 1500 ml or hemothorax drainage of > 200 ml/hr x 3hrs 2. Caked hemothorax (persistance of a large hemothorax even after a 2nd chest tube 3. Large air leak with inadequate ventilation or persistant collapse of the lung 4. esophageal perforation 5. Cardiac tamponade |
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| Management of a through-and-through injuring to a single lung lobe with an active air leak and bleeding |
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| Pulmonary tractotomy: insertion of linear staple into the bullet hole to create two staple lines and ligating the lung in between to allow access to the bleeding vessels and leaking bronchi |
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| Grading system of duodenal injuries |
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| I-V; Grade I is a simple hematoma and grad V is a massive disruption of a pancreatico duodenal complex |
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| Management of a simple duodenal hematoma |
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| # If recognized pre-operatively, NGT and TPN; # If found intraoperatively and small, leave it alone # If large (involving > 50% of lumen), incise the serosa, drain the hematoma, and reclose the serosa |
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| Management of a full-thickness duodenal laceration |
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| Primary repair, closing transversely, with an omental patch |
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| management of a large ( > 50% of the luminal circumference) duodenal injury |
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| # 1st or 4th portion: resection with a duodenoduodenostomy # 2nd or 3rd and the ampula is not injuried: RNY duodenojejunostomy # distal to the ampula, distal portion of the duodenum is oversewn and EEA anastamosis of jejunum to prox duodenum and drainage of distal duodenum into jejunum |
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| Trauma indication for a Whipple |
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| Massive dissruption of the pancreatic head and duodenum |
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| Management of a pancreatic injury without ductal disruption |
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| Drainage |
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| Management of a distal pancreatic injury with dictal disruption |
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| distal pancreatectomy |
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| Physical exam suggestive of neurogenic shock |
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| Hypotension, relative bradycardia, WWP extremities (reflecting loss of sympathetic tone), evidence of high spinal cord injury and priapism (unopposed parasympathetic stimulation) |
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| Management of hypotension in patient with neurogenic shock |
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| Fluids; once adequately resuscitated, pure alpha agonist- phenylephrine (Neo) |
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| A positive DPL |
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| 1. > 10 mL of free blood aspirated 2. > 100,000/m3 RBC for blunt trauma and > 5000/m3 RBC for penetrating trauma 3. the detection of bile, amylase or vegetable or fecal matter 4. WBC > 500/m3 |
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| Grades of a kidney injury |
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| I: Contusion or subcapsular and non-expanding hematoma II: III: deep lacerations that do not involve the collecting system IV: lacerations involving the collecting system or injury to the man renal artery V: completely shattered kidney or avulsion of the renal hilum |
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| Management of kidney injury |
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| any injury can be managed non-operatively as long as pt is HD stable |
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| management of renal trauma with urinary extravasation |
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| Observation with possible percutaneous drainage or urinary stent placement if it does not resolve on it's own. |
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| Methods of lowering ICP |
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| 1. hypertonic saline with Na goal 155-160 2. mild hyperventilation with pCO2 > 30 (goal is to decrease swelling by causing vasoconstriction, too much vasoconstriction is bad) 3. Mannitol 4. EVD 5. Barbiturate coma to decrease metabolic demands of brain |
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| Management of colonic injuries |
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| # primary repair if less than 50% of the circumference is involved # resection for > 50% circumferential involvement with primary anastamosis if pt stable (and not required too much blood) or possibly if morbidly obese # resection and colostomy if large wound and unstable |
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| Cushing reflex |
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| Hypertension and bradycardia in setting of traumatic inctracranial bleeding |
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| Of the possible sources of significant bleeding, the one that takes precedence over the others |
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| Peritoneal |
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| 3 radiographic findings suspicious for aortic transection |
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| 1. depressed left mainstem bronchus 2. widened mediastinum 3. deviated trachea |
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| Factors that make primary amputation of the leg a better option |
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| 1. hemodynamic instability 2. ischemia > 6 hrs 3. complete traumatic amputation 4. tib/fib fx with large soft tissue defect and arterial injury 5. transection of the tibial nerve |
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| Way to diagnose duodenal perforation in the setting of an equivocal CT |
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| Upper GI series with water solube contrast that shows "coiled spring" appearance of the duodenal wall |
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| Stages of damage control surgery |
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| 1. abreviate resuscitative surgery in which hemorrhage and bowel contamination are controled with packing and a temporary abd closure (delay repair of non-life threatening injuries) 2. rewarm, resuscitate and fix coagulopathy in ICU and look for other injuries 3. re-exploration after restoration of normal physiology to remove packs and complete any additional repairs |
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| Type of injury which is a contra-indication to damage control surgery |
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| Arterial injuries |
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| Type of liver injury amenable to suturing and best method for liver suturing |
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| # Superficial lacerations # Chromic suture with blunt needle |
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| Indications for immediate OR explioration of neck wounds |
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| # hard signs fo vascular injury: rapidly expanding hematoma or visible exanguination # shock, even without hard signs b/c the presumption is that the pt exsanguinated in the field |
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| Management of penetrating neck trauma |
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| # To OR if hemodynamically unstable or hard signs of vascular injury # If hemodynamically stable, 4-vessel arteriography or CTA of neck # When feasible, assessment for injuries to the aerodigestive tract (triple endoscopy and/or esophagoscopy) and C-spine # Xray of head neck and chest to look for the bullet |
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| Management of Carotid artery injury |
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| repair if neurological deficit |
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| Definition of flail chest |
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| 3 or more ribs fractured in at least 2 locations |
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| Indications for internal fixation of the chest wall |
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| # flail chest in pts already undergoing thoracotomy for an intrathoracid injury # Flail chest without pulmonary contusion # noticeable paradoxical movement while pt is being weaned # severe deformity of chest wall |
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| Pulsatile exophthalmos in a pt with racoon eyes and/or hemotympanum |
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| Carotid-cavernous fistula |
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| Signs of carotid-cavernous fistula |
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| # pulsatile exophthalmous # eyelid edema # auscultation of a bruit over the eye # edema of the conjunctiva # double vision # swelling of the eye |
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| Management of caroitid-cavernous fistula |
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| open neurosurgical approach or endovascular embolization |
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| Signs of compartment syndrome |
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| # pain out of proportion to the injury # pain on passive motion of the limb # tense edema with tenderness on palpation fo the compartment |
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| # First compartment to be involved in compartment syndrome of the leg # Sx of involvement of that compartment # pathogenesis of said sx |
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| # Anterior compoartment of the leg # numbness in the first web space # entrapment of the deep peroneal nerve which runs in the anterior compartment |
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| In compartment syndrome: # compartment most difficult to decompress # structure contained in that compartment # best way to decompress that compartment |
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| # deep posterior compartment # tibial nerve # detachment of the soleus muscle from the tibia |
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| Grades of traumatic peripheral nerve injuries and definition |
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| # Neuropraxia- focal demyelination from stretch or compression; axon is intact so conduction proximal and distal to the lesion is in tact # Axonotmesis- axon is damagamed but surrounding structures preserved which allows regeneration to occur # Neurotmesis- complete transection or disruption; |
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| Type of peripheral nerve injury a/w distal wallerian degeneration |
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| Axonotmesis |
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| Types of peripheral nerve injuries which are amenable to regeneration and which require surgical repair |
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| # regeneration: neuropraxia and axonotmesis # requires surgery: neurotmesis |
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| MC traumatic peripheral nerve injury |
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| # Upper extremity more common than lower # MC periph nerve injury: radial nerve a/w humerus fx # MC lower extremity periph nerve injury is peroneal nerve a/w posterior knee dislocation |
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| Rate at which peripheral nerves regenerate |
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| 1 mm/day |
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| Grading of pancreatic injuries |
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| # I- minor contusion or laceration # II- # III # IV # V: major disruption of pancreatic head |
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| Management of pancreatic injuries |
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| # 1st step is to determine of the main pancreatic duct is injured and whether it is injured to the R or L of the superior mesenteric vessels--> pancreatography via contrast injected into the GB # if duct disrupted to the left of mesenteric vessels: distal pancreatectomy # if disrupted to R but no major head disruption: drainage and delayed pancreaticoenteric anastomosis if fistula fails to heal # if disrupted to R with major head disruption: pancreaticoduodenectomy # any such operation can be delayed if damage control laparotomy needed |
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| Indications for Whipple in trauma |
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| # injury to main pancreatic duct to R of mesenteric vessels and massive disruption of pancreatic head # devascularization of duodenum |
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| Beck's Triad |
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| Distended neck veins, muffle heart sounds, hypotension==>> pericardial tamponade |
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| Management of tamponade |
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| # IVF first, especially if early, because volume can overcome the tamponade # if stable, fast exam looking for tamponade or abd free fluid; if tamponade confirmed --> OR for median sternotomy and repair # if unstable, left anterolateral thoracotomy in ED, longitudinal incision in pericardium avoiding phrenic nerve, evacuate clot and finger in the injury |