Substance Abuse Chapter 4 study questions – Flashcards
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The process of maintaining our internal environment within certain limits is called ___.
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homeostasis
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In addition to neurons, the brain contains an even larger number of another cell type known as ___.
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glia
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Which of these is NOT one of the four important regions found in every neuron? -cell body -dendrites -axon -glia
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glia
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Gated ion channels for sodium and potassium open and close in rapid succession, causing the neuron to depolarize and then return to its normal resting level, during each ___.
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action potential
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Cocaine selectively blocks Na+ (sodium) channels, which is the mechanism that leads to ___.
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local anesthetic effects
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The disease ___ results from a loss of myelin wrappings.
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multiple sclerosis
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Parasympathetic and sympathetic refer to the two branches of the ___.
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autonomic nervous system
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Parkinson's disease produces tremors and muscular rigidity because of damage to ___.
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dopamine neurons in the nigrostriatal pathway
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The neurotransmitter at the end organ of the sympathetic branch of the autonomic nervous system is ___.
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norepinephrine
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The ___ is an important link between the brain and the pituitary gland, and is involved in feeding, drinking, temperature regulation and sexual behavior.
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hypothalmus
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Neural centers controlling vomiting and respiration are found in the ___.
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Brain stem
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Which chemical pathway appears to be important both in some types of psychotic behavior and in the reinforcing properties of various drugs?
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mesolimbic dopamine pathway
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Weight control, aggression, impassivity and psychological depression have all been associated with ___.
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serotonin pathways
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Natural chemicals in the brain that produce effects similar to those of morphine and other opium-derived drugs are called ___.
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endorphins
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The process in which enzymes within neurons convert precursors into neurotransmitter molecules is called ___.
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synthesis
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Neurotransmitter molecules are released into the small space between two neurons called the ___.
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synapse
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Specialized structures that recognize neurotransmitter molecules and when activated may cause a change in the electrical activity of the neuron, are called ___.
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receptors
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Which of the following neurotransmitters is found in most parts of the brain and is considered inhibitory?
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GABA
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Whether the effect of a neurotransmitter is excitatory or inhibitory depends on ___.
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the type of receptor
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Drugs can effect neurotransmitter systems in two main ways: either by altering the availability of the neurotransmitter in the synapse, or by ___.
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acting directly on the receptors
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Suppose you wanted to prescribe a hypothetical drug that would have an overall excitatory effect on the nervous system. Which would you choose? -a glutamate metabolizer -a dopamine metabolizer -a GABA antagonist -a norepinephrine antagonist
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a GABA antagonist
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The brain imaging technique that involves injection of radioactive chemicals in order to measure brain function is called ___.
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positron emission tomography (PET)
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T or F. Unlike neurons, glial cells in the brain are purely for support and are incapable of communication with each other.
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False
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T or F. The complex branching parts of a neuron that receive information from other neurons are called dendrites.
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True
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T or F. In the neuron, neurotransmitters are stored in the myelin sheaths.
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False
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T or F. It is possible to have an action potential that is relatively small in magnitude (if few channels are open).
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True
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T or F. Parkinson's patients are often treated with dopamine because L-dopa cannot cross the blood-brain barrier.
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False
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T or F. One of the main ways that drugs can affect neurotransmitter systems is by cutting off blood flow to a specific brain structure.
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False
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MRI and PET are two types of neurotransmitter chemicals.
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False
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GABA and glutamate are similar in that they are found throughout the brain and are primarily inhibitory neurotransmitters.
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False
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Describe the structure of a neuron.
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Neurons have four regions: -cell body: containing the nucleus -dendrites: treelike features that extend from the cell body and contain receptors -axon: long slender extension of the cell body responsible for conducting the action potential to the axon terminals -axon terminals: bulbous structures at the end of the axon where neurotransmitters are stored in vesicles
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Describe the differing effects of the sympathetic and parasympathetic branches of the autonomic nervous system.
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Sympathetic-"fight or flight" reactions: opens bronchi, decreases blood supply to skin, increases heart rate, reduces stomach motility, dilates pupils Parasympathetic-inhibits heart rate, constricts pupils, increases stomach motility, dilates skin blood vessels, constricts bronchi
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What are the steps involved in the life cycle of a neurotransmitter?
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-uptake of precursors -synthesis of transmitter -storage in vesicles -release into the synapse -interaction with the receptor -reuptake into the releasing neuron -metabolism by enzymes
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The actions of drugs on neurotransmitter systems can be divided into two main types. What are they?
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Drugs can alter the availability of the neurotransmitter in the synapse or affect the receptors by: -mimicking the action of the neurotransmitter -occupying the receptor preventing the neurotransmitter from activating