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Home Page Flashcards PD173074 C28H41N7O3 structure - Flashcards

PD173074 C28H41N7O3 structure – Flashcards

Flashcard maker : Alexander Rose

C28H41N7O3 structure
Molecular Formula C28H41N7O3
Average mass 523.670 Da
Density 1.2±0.1 g/cm3
Boiling Point
Flash Point
Molar Refractivity 153.8±0.3 cm3
Polarizability 61.0±0.5 10-24cm3
Surface Tension 48.7±3.0 dyne/cm
Molar Volume 450.2±3.0 cm3
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Experimental Physico-chemical Properties

    • Experimental Melting Point:

      98-100 °C LabNetwork LN00198200

    • Experimental Solubility:

      10 mM in DMSO MedChem Express HY-10321
      Soluble in DMSO and Ethanol Axon Medchem 1673
      Soluble to 100 mM in DMSO and to 100 mM in ethanol Tocris Bioscience 3044
  • Miscellaneous

    • Safety:

      5 Axon Medchem 1673
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1673
      IRRITANT Matrix Scientific 097442
      no pictogram Axon Medchem 1673
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1673
      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3044
      Warning Axon Medchem 1673

    • Target Organs:

      FGFR inhibitor; VEGFR inhibitor; Src inhibitor TargetMol T2642

    • Bio Activity:

      Enzyme-Linked Receptors Tocris Bioscience 3044
      FGFR Tocris Bioscience 3044
      FGFR MedChem Express HY-10321
      FGFR1 and -3 inhibitor Tocris Bioscience 3044
      FGFR1;VEGFR2;c-Src;EGFR TargetMol T2642
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src. MedChem Express
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.; IC50 value: ~25 nM (FGFR1); 100-200 nM (VEGFR2) [1]; Target: FGFR1; VEGFR; in vitro: PD173074 is an ATP-competitive inhibitor of FGFR1 with Ki of ~40 nM. MedChem Express HY-10321
      PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM, ~1000-fold selective for FGFR1 than PDGFR and c-Src.;IC50 value: ~25 nM (FGFR1); 100-200 nM (VEGFR2) [1];Target: FGFR1; VEGFR;In vitro: PD173074 is an ATP-competitive inhibitor of FGFR1 with Ki of ~40 nM. PD173074 is also an effective inhibitor of VEGFR2. Compared to FGFR1, PD173074 weakly inhibits the activities of Src, InsR, EGFR, PDGFR, MEK, and PKC with 1000-fold or greater IC50 values. PD173074 inhibits autophosphorylation of FGFR1 and VEGFR2 in a dose-dependent manner with IC50 of 1-5 nM and 100-200 nM, respectively[1]. PD173074 inhibits FGF-2 promotion of granule neuron survival in a dose-dependent manner with IC50 of 12 nM, exhibiting 1,000-fold greater potency than that of SU 5402 [2]. PD173074 specifically inhibits FGF-2-mediated effects on proliferation, differentiation, and MAPK activation in oligodendrocyte (OL) lineage cells [3].;In vivo: Administration of PD173 MedChem Express HY-10321
      Protein Tyrosine Kinase/RTK MedChem Express HY-10321
      Protein Tyrosine Kinase/RTK; MedChem Express HY-10321
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 3044
      Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEG
      F- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expres
      sing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. Tocris Bioscience 3044
      Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models. Tocris Bioscience 3044
      Tyrosine Kinase/Adaptors TargetMol T2642

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.599
Molar Refractivity: 153.8±0.3 cm3
#H bond acceptors: 10
#H bond donors: 3
#Freely Rotating Bonds: 13
#Rule of 5 Violations: 2
ACD/LogP: 3.33
ACD/LogD (pH 5.5): 0.91
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 2.90
ACD/LogD (pH 7.4): 1.23
ACD/BCF (pH 7.4): 1.09
ACD/KOC (pH 7.4): 6.01
Polar Surface Area: 114 Å2
Polarizability: 61.0±0.5 10-24cm3
Surface Tension: 48.7±3.0 dyne/cm
Molar Volume: 450.2±3.0 cm3

Click to predict properties on the Chemicalize site

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