Bio 1404 Chapter 9: The Cell Cycle – Flashcards
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Starting with a fertilized egg (zygote), a series of five cell divisions would produce an early embryo with how many cells?
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32
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If there are 20 Chromatids in a cell, how many centromeres are there?
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20
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In eukaryotic cells, chromosomes are composed of DNA
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and proteins
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What is produced if a cell divides by mitosis but does not undergo cytokinesis?
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One cell with two nuclei, each identical to the nucleus of the parent cell.
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Humans produce skin cells by mitosis and gametes by meiosis. The nuclei of skin cells produced by mit. will have
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Twice as much DNA as the nuclei of gametes produced by meiosis
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Compared to most prokaryotic cells, eukaryotic cells typically have
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More DNA molecules and larger genomes
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At which phase are centrioles beginning to move apart in animal cells?
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Prophase
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If there are 20 centromeres in a cell at anaphase, how many chrom. are in each daughter cell following cytokinesis?
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10
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Where do the microtubules of the spindle originate during mitosis in animal cells?
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Centrosome
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Taxol is anticancer drug...in animal cells, it disrupts microtubule formation by binding them an accelerating assembly from Tubulin..stops mitosis affecting
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the formation of mitotic spindle
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Which of the following are primarily responsible for cytokinesis in plant cells but not in animal cells?
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Golgi-derived vesicles
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Movement of the chromosomes during anaphase would be most affected by a drug that prevents
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Shortening of microtubules
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Measurements of the amount of DNA per nucleus were taken on a large number of cells from a growing fungus. The measured DNA levels ranged from 3 to 6 picograms per nucleus. In which stage of the cell cycle did the nucleus contain 6 picograms of DNA?
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G2
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A group of cells is assayed for DNA content immediately following mitosis and is found to have an average of 8 picograms of DNA per nucleus. How many picograms would be found at the end of S and the end of G2?
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16;16
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The beginning of anaphase in indicated by which of the following?
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Cohesion is cleaved enzymatically.
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During which phase of mitosis do the chromatids become chromosomes?
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Anaphase
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What is a cleavage furrow?
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A groove in the plasma membrane between daughter nuclei
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Using which of the following techniques would enable your lab group to distinguish between a cell in G2 and a cell from the same organism in G1?
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Radioactive-labeled nucleotides
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You have the technology necessary to measure each of the following in a sample of animal cells: chlorophylls, organelle density, picograms of DNA, cell wall components, and enzymatic activity. Which would you expect to increase significantly from M to G1?
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Organelle density and enzymatic activity
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A plant-derived protein known as colchicine can be used to poison cells by blocking the formation of the spindle. Which of the following would result if colchicine is added to a sample of cells in G2?
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The chromosomes would coil and shorten but have no spindle to which to attach.
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Motor proteins require which of the following to function in the movement of chromosomes toward the poles of the mitotic spindle?
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ATP as an energy source.
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When a cell is in late anaphase of mitosis, which of the following will we see?
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A clear area in the center of the cell
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Cells from advanced malignant tumors often have very abnormal chromosomes as well as an abnormal number of chromosomes. What might explain the association between malignant tumors and chromosomal abnormalities?
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Cell cycle checkpoints are not in place to stop cells with chromosome abnormalities.
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Which is the first checkpoint in the cell cycle where a cell will be caused to exit the cycle if this point is not passed?
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G1
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Which of the following is released by platelets in the vicinity of an injury?
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PDGF
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Which of the following is a protein synthesized at specific times during the cell cycle that associates with a kinase to form a catalytically active complex?
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Cyclin
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Which of the following is a protein maintained at constant levels throughout the cell cycle that requires cyclin to become catalytically active?
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Cdk
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Which of the following triggers the cell's passage past the G2 checkpoint into mitosis?
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MPF
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The cyclin component of MPF is destroyed toward the end of which phase?
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M
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Proteins that are involved in the regulation of the cell cycle, and that show fluctuations in concentration during the cell cycle, are called
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Cyclins
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The MPF protein complex turns itself off by
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Activating a process that destroys cyclin components
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Density-dependent inhibition is explained by which of the following?
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As cells become more numerous, the cell surface proteins of one cell contact the adjoining cells and they stop dividing.
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Which of the following is true concerning cancer cells?
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When they stop dividing, they do so at random points in the cell cycle; they are not subject to cell cycle controls; and they do not exhibit density-dependent inhibition when growing in culture.
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Which of the following describes cyclin-dependent kinase (Cdk)?
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Cdk is present throughout the cell cycle and is an enzyme that attaches phosphate groups to other proteins.
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Besides the ability of some cancer cells to overproliferate, what else could logically result in a tumor?
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Lack of appropriate cell death
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Why do neurons and some other specialized cells divide infrequently?
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They have been shunted into G0
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Which of the following most accurately describes a cyclin?
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It activates a Cdk molecule when it is in sufficient concentration.
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All cell cycle checkpoints are similar in which way?
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They give the go-ahead signal to progress to the next checkpoint.
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At the M phase checkpoint, the complex allows for what to occur?
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Separase enzyme cleaves cohesins and allows chromatids to separate.
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Anchorage dependence of animal cells in vitro or in vivo depends on which of the following?
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response of the cell cycle controls to signals from the plasma membrane
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Researchers began a study of a cultured cell line. Their preliminary observations showed them that the cell line did not exhibit either density-dependent inhibition or anchorage dependence. What could they conclude right away?
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The cells show characteristics of tumors.
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For a chemotherapeutic drug to be useful for treating cancer cells, which of the following is most desirable?
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It interferes with rapidly dividing cells.
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You have a series of cells, all of which were derived from tumors, and you first need to find out which ones are malignant. What could you do?
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Karyotype samples to look for unusual size and number of chromosomes.
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What is the correct chromosomal condition for one daughter nucleus at telophase of mitosis?
(Fig 9.1)
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E
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If the cell whose nuclear material is shown in Figure 9.2 continues toward completion of mitosis, which of the following events would occur next?
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Formation of the telophase nuclei
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In Figure 9.3, mitosis is represented by which numbered part(s) of the cycle?
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IV
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G1 is represented by which numbered part(s) of the cycle? (Fig 9.3)
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I or V
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Which number represents DNA synthesis? (Fig 9.3)
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II
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Which number represents the point in the cell cycle during which the chromosomes are replicated? (Fig 9.3)
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II
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At which of the numbered regions would you expect to find cells at metaphase? (Fig 9.3)
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III Only
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MPF reaches its threshold concentration at the end of this stage.
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III
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A particular cell has half as much DNA as some other cells in a mitotically active tissue. The cell in question is most likely in
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G1
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The drug cytochalasin B blocks the function of actin. Which of the following aspects of the animal cell cycle would be most disrupted by cytochalasin B?
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Cleavage furrow formation and cytokinesis
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Which of the following does not occur during mitosis?
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Replication of the DNA
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In the cells of some organisms, mitosis occurs without cytokinesis. This will result in
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Cells with more than one nucleus
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Through a microscope, you can see a cell plate beginning to develop across the middle of a cell and nuclei forming on either side of the cell plate. This cell is most likely
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a plant cell in the process of cytokinesis.
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Several organisms, primarily protists, have what are called intermediate mitotic organization. These protists are intermediate in what sense?
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They maintain a nuclear envelope during division.
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Several organisms, primarily protists, have what are called intermediate mitotic organization. What is the most probable hypothesis about these intermediate forms of cell division?
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They show some but not all of the evolutionary steps toward complete mitosis.
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(Data table 9.1) Of the following, the best conclusion concerning the difference between the S phases for beta and gamma is that
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Gamma contains more DNA than beta.
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(Data table 9.1) The best conclusion concerning delta is that the cells
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Are actually in the G0 phase