Chapter 18 Blood Anatomy – Flashcards
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erythrocytes
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red blood cells
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leukocytes
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white blood cells
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platelets
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help clot blood
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plasma
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fluid portion
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what does blood transport?
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oxygen, carbon dioxide, hormones, nutrients, waste products
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what does blood regulate?
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body temperature, pH, fluid balance
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about how much blood is in an adult?
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5 liters
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why do veins appear blue?
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the way blue light is reflected back to the eye
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how much more viscous is blood than water?
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4-5 times
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what is the pH of blood?
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between 7.35-7.45
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what is the temperature of blood?
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about one degree higher than body temperature
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albumins
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smallest and most abundant plasma proteins, 58%
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globulins
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37%, smaller alpha-globulins and larger beta-globulins
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gamma globulins
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immunoglobulins or anitbodies
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fibrinogen
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contribute to blood clot formation
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serum
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plasma with clotting proteins removed
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regulatory proteins
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enzymes to accelerate chemical reactions
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hemopoiesis
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continual production of formed elements occurs in red bone marrow
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colony-stimulating factors
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increase formation of specific formed elements
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thrombopoietin
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stimulates production of platelets
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erythropoietin (EPO)
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hormone produced by kidneys that increases rate of production of erythrocytes
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hemocytoblasts
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hemopoietic stem cells that can differentiate into many types of cells
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myeloid line
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forms erythrocytes and leukocytes
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lymphoid line
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forms lymphocytes
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erythropoiesis
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erythrocyte production
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leukopoiesis
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leukocyte production
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thrombopoiesis
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platelet production
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megakaroblast
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produced by myeloid stem and forms megakarocyte
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spectrin protein
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provides support and flexibility to erythrocyte
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hemaglobin
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red pigmented protein
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oxyhemoglobin
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bound to oxygen
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deoxyhemoglobin
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not bound to oxygen
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carbaminohemoglobin
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carbon dioxide bound to amino acid group
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heme group
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contains porphyrin ring and an iron ion in center, which binds oxygen for transport
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how many oxygen molecules can each hemoglobin bind to?
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four
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what stimulates EPO (erthropoietin)?
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decreased blood oxygen (altitude, exercise, blood loss)
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hemolysis
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rupture of erthyrocyte
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diapedesis
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leukocytes squeezing through endohelial cells of blood vessels
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chemotaxis
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attraction of leukocytes to infection site
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granulocytes
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visible granules seen with light microscope
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agranulocytes
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smaller granules not seen with light microscope
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neutrophils
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most numerous leukocyte
multilobed nucleus
phagocytize infectious pathogens
increase with bacterial infection
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eosinophils
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bilobed nucleus
phagocytize antigen-antibody complexes or allergens
active in parasitic infection
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basophils
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bilobed nucleus
histamine (vasodialation)
heparin inhibits blood clotting
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lymphocytes
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T-lymphocytes manage immune response
B-lymphocytes become plasma cells and produce antibodies
NK cells attack abnormal and infected tissue cells
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monocytes
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c shaped nucleus
transform into macrophages
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leukopenia
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reduced number of leukocytes, increases risk of developing infection
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leukocytosis
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slightly elevated leukocyte count, may be caused by infection or stress
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neutrophilia
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increase in neutrophils
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neutropenia
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decreased neutrophil count
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lymphocytosis
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increase in lymphocytes
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lymphocytopenia
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decreased lymphocyte count
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platelets characteristics
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membrane enclosed cellular fragments without a nucleus, blood clotting
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thrombocytopenia
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abnormally small number of platelets in blood
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hemostasis
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process of blood clotting
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what are the three phases of hemostasis (blood clotting?
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vascular spasm
platelet plug formation
coagulation phase
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vascular spasm
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sudden constriction of blood vessels that limits blood able to leak from vessel. increased by the release of serotonin and thromboxane A2
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platelet plug
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formed from platelets arriving at injury site
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prostacyclin
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local hormone that coats the endothelial wall that keeps it very smooth
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von willebrand factor
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plasma protein that is released from platelets and endothelium cells
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degranulation
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massive release if chemicals stored in granules
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coagulation
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blood clotting
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clot retraction
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occurs as clot is forming
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actinomyosin
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contractile protein within platelets contracts and squeezes the serum out of a developing clot
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fibrinolysis
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actual clot destruction
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plasmin
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enzyme
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if more than 10% of blood is lost, what is the sympathetic response?
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increased vasoconstriction
increased heart rate
increased force of heart contraction
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plasma is composed of about ____% of water
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92
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protein that maintains osmotic pressure
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albumin
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transports lipids
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alpha and beta globulin
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a type of antibody for defense
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gamma globulin
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helps with blood clotting
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fibrinogen
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used and produced in cellular respiration
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plasma gasses
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vitamins, lipids, sugars, amino acids transported to cells for use in metabolic processes
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plasma nutrients
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waste produced in metabolism and amino acids
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nonprotein nitrogenous substances
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the most abundant formed elements of the blood is/are
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erythrocytes
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choose the correct statement regarding the function of platelets.
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they secrete procoagulants, or clotting factors, which promote blood clotting
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the cell fragments that are a component of blood are
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platelets
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if an individual's erythrocytes exhibit surface antigen D, the person is said to be Rh negative.
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false
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a simple protein that makes up approximately 58% of the plasma proteins. Many act as transport molecules
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albumin
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a simple protein that makes up approximately 38% of the plasma proteins. Many act as part of the immune system
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globulin
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a protein that forms blood clots
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fibrin
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plasma without the clotting factors
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serum
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the liquid portion of blood connective tissue
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plasma
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in a patient, the differential count shows neutrophil levels are very high. This may indicate a(n)
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bacterial infection
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the red pigmented protein in erythrocytes that transports oxygen and carbon dioxide is called
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hemoglobin
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leukocytes in the elderly are usually more efficient and higher in number compared to earlier in life.
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false
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a deficiency in leukocyte number may lead to an increase in opportunistic infections.
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true
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platelets are formed from
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pieces of the megakaryocyte breaking off