oncology NAPLEX review – Flashcards
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pulmonary fibrosis (myelosuppression also)
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busulfan hallmark toxicity
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nausea and vomiting (peripheral neuropathy, nephro and ototox)
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cisplatin hallmark toxicity
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hemorrhagic cystitis, myelosuppression (can give hydration with this - must give with ifosfamide)
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cyclophosphamide hallmark toxicity
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peripheral neuropathy
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oxaliplatin
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pneumonitis (pulmonary fibrosis)
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bleomycin hallmark toxicity
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cardiotoxicity (and alopecia, and myelosuppression
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doxo, dauno, ida rubicin hallmark tox
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capecitabine (XELODA)
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oral prodrug of 5FU
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cytarabine
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monitor handwriting to check neurotox with this drug
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capecitabine
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hand-foot syndrome is associated with what chemo agent
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mucositis, myelosuppression, pulmonary fibrosis, hepatotoxicity, nephrotoxicity (affects almost every organ - given once weekly)
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methotrexate toxicities (list)
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myelosuppression
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toxicity of gemcitabine
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stomatisis, myelosuppression, N/V, diarrhea
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5 - FU toxicities
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fluid retention, complete alopecia
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docetaxel toxicities
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paclitaxel
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cremophore that this chemo agent is prepared in may cause anaphylaxis
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peripheral neuropathy, complete alopecia
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paclitaxel toxicities
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myelosuppression
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vinblastine toxicity
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peripheral neuropathy (DON'T GIVE INTRATHECALLY)
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vincristine toxicity
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vincristine
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do not give ____ intrathecally
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diarrhea
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irinotecan toxicity
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n/v, myelosuppression
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topotecan toxicity
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orally
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any cancer drug that ends in "nib" can be taken ____
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CML (first line agent)
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dasatinib indication
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CML (first line agent)
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imatinib indication
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Lung cancer (acne like rash toxicity because of EGFR MOA)
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erlotinib indication
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CML (first line agent)
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nilotinib indication
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Breast cancer (toxicity is diarrhea)
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lapatinib indication
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NIB (can be taken orally)
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suffix for tyrosine kinase inhibitors
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TKIs (cyp 3A4 and antacids)
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DDIs common with what class of chemo
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AML M3
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ATRA (tretinoin) used in what disease _____
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peripheral neuropathy
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bortezomib associated with what toxicity?
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blood glucose (can cause hyperglycemia)
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monitor ____ in patients on temsirolimus
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reactivation of hepatitis B
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rituxan's black box warning
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HER2/NEU breast cancers, cardiotoxicity
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trastuzumab indication and hallmark toxicity
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bleeding ( it's a VEGF which inhibits angiogenesis)
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bevacizumab toxicities
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fatal enterocolitis (can be treated if caught early with high dose corticosteroids)
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ipilimumab associated with what toxicity
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G-CSF, for neutropenia EPO for anemia (palliative only)
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treatment for bone marrow suppression in chemo patients
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rubicins and taxanes (doxorubicin and paclitaxel)
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which chemo agents most associated with alopecia ?
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doxorubicin-DMSO, vincas-heat
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Which chemo agents most associated with extravasation?
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ifosfamide (and cyclofosfamide - can give MESNA)
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which chemo agents most associated with hemorrhagic cystitis?
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etoposide and cyclophosphamide
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which chemo agents most associated with secondary malignancies?
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tamoxifen
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which chemo agent is associated with increased incidence of endometrial cancer?
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5 years
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what is the recommended duration of tamoxifen?
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metastatic colon cancer
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FOLFOX regimen used in _____
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peripheral neuropathy (especially to the cold - gloves for the fridge)
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oxaliplatin associated with what hallmark toxicity
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bactrim (given to immunosuppressed patients)
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prophylaxis for PCP drug
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non hodgkins lymphoma
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R-CHOP indication (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone)
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colon cancer (stage 3)
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FOLFOX (5FU, leukovorin, oxaliplatin) indication
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AML
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7 + 3 indication (cytarabine + idarubicin)
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breast cancer
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AC indication (doxorubicin and cyclophosphamide)
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HER2/NEU + breast cancer
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herceptin (trastuzumab) indication
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CML
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gleevex indication
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cisplatin, cyclophosphamide ,(AC therapy) doxorubicin (require aprepitant or fosarepitant + 5HT + dexamethasone)
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what are the highly emetogenic chemotherapies?
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increase K, uric acid, phosphate, decreased Ca
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electrolye abnormalities with tumor lysis syndrome
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pamidronate, zoledronic acid, calcitonin
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drugs used in hypercalcemia of malignancy
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saline (incompatible with dextrose alone)
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cisplatin requires ____ for dispensing
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non-PVC tubing
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paclitaxel dispensing req
