Micro Chapter 6 Test – Flashcards

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Viruses have typical cellular structure like other living organisms. T/F
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False
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Viruses in the extracellular state possess few, if any, active enzymes. T/F
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True
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Which is not true of viruses?
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The infect animal and plant cells only
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Which of the following is true of viruses in the extracellular phase?
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They behave as a macromolecular complex and are no more alive than are ribosomes.
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A complete virus particle is called a
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virion
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The nucleic acids carried by viruses usually consist of
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either DNA or RNA
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Which of the following is not true of viruses?
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Viruses replicate by binary fission
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Viruses infecting protists, including algae, have never been detected. T/F
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False
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One way in which small viruses package more information into a very small genome is to use overlapping genes so that the same base sequence is read in more than one reading frame. T/F
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True
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Almost all known plant viruses are RNA viruses. T/F
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True
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Virus morphology does not include which of the following characteristics?
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Host range
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__________ are glycoprotein spikes protruding from the outer surface of the viral envelope.
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peplomers
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Icosahedral viruses are constructed from ring- or knob-shaped units called __________.
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Capsomers
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Viruses that are polyhedrons with 20 sides are said to have __________ symmetry.
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icosahedral
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The most common capsid morphologies are icosahedral and helical. T/F
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True
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The largest of the viruses are similar in size to some small bacteria and are large enough to be seen with a light microscope. T/F
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True
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The presence or absence of an envelope is not useful in classifying viruses because any given virus may at one time have an envelope and at another time not have an envelope. T/F
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False
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Viruses such as MS2 and Qß pack additional information into their genomes through the use of overlapping genes. T/F
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True
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The simplest viruses consist of
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RNA or DNA in a protein coat
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Viral capsid protein subunits are called
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protomers
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In an enveloped virus, the part of the virus including the nucleic acid genome and the surrounding protein coat but not the envelope is called the
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nucleocapsid
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Some complex viruses have icosahedral symmetry in the head region and helical symmetry in the tail. Overall, these viruses are said to have __________ symmetry.
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binal
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Glycoprotein spikes protruding from the outer surface of viral envelopes function as
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factors that bind to host cells
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A __________ genome exists as several separate, nonidentical molecules that may be packaged together or separately.
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segmented
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Many of the enzymes found in virus particles are
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involved in the replication of viral nucleic acid
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Which of the following is/are not true about viral envelopes?
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They are typical lipid monolayers with embedded viral proteins
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Viral envelopes are composed of
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proteins, lipids, carbohydrates
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Two major types of symmetry found in viruses include
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icosahedral and helical
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The function of the viral protein coat is to
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protect the viral genetic material and aid in the transfer of the viral genetic material between host cells.
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The protein coat surrounding the viral genome is called the
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capsid
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Which of the following is most true of a viral DNA genome?
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It may have the normal bases found in prokaryotic and eukaryotic DNA, or it may have one or more unusual bases.
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Virion size ranges from
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10-400nm
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Viral capsids are generally constructed without any outside aid once the subunits have been synthesized. This process is called
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self assembly
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In which of the following stages of the viral infectious cycle do enveloped viruses usually acquire their envelopes?
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release
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Most enveloped viruses use the host __________ membrane as their envelope source.
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plasma
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Poliovirus receptors are found
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in nasopharynx, gut, and spinal cord anterior horn cells
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Nonenveloped viruses most often gain access to eukaryotic host cells by
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endocytosis
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Which of the following represent(s) the way(s) in which enveloped viruses acquire their envelopes?
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Budding through the plasma membrane, Budding through internal cellular membranes.
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Virus receptors are often not distributed uniformly over the surface of host cells, but are instead concentrated in lipid rafts. T/F
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True
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Enveloped viruses may enter their host cells by fusion of their envelope with the cytoplasmic membrane, thereby depositing their nucleocapsid within the cell. T/F
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True
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Enveloped viruses may enter their host cells by engulfment within coated vesicles (endocytosis). T/F
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True
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Some viruses cause abnormal growth of cells rather than destruction. This is called __________.
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transformation
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Human cancer causing viruses most often have a ___________ genome.
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dsDNA
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Adult T-cell leukemia is thought to be caused by
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retroviruses
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Genes whose expression (or abnormal expression) causes cancer are called
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pncpgenes
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Which of the following has been associated with a form of liver cancer?
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Hepatitis B virus.
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Microscopic or macroscopic degenerative changes or abnormalities in infected host cells and tissues are called __________ __________.
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cytopathic effects
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In a plaque assay, the number of infectious virions is usually identical to the number of virus particles present. T/F
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False
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Animal viruses have been cultivated in
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suitable host animals, embryonated eggs, tissue cultures (monolayers of animal cells).
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Which of the following can be used to cultivate plant viruses?
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Cultures of separated plant cells, Whole plants, Plant protoplast cultures.
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0.2 mls of a 10-4 dilution of a virus preparation yields 90 plaques. What is the number of PFU per ml in the undiluted virus preparation?
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4.5 *10^6
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A ________ assay is most useful for determining the viability of a viral preparation?
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plaque
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Hemagglutination is
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the clumping together of red blood cells in the presence of a viral suspension.
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Like bacteria and eukaryotic microorganisms, most viruses can be cultured using artificial media. T/F
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False
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Bacterial viruses are so named because they have prokaryotic cell structures similar to their bacterial hosts. T/F
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False
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Localized areas of destruction occurring on plants that have been infected by a virus are referred to as __________ lesions.
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necrotic
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Which of the following is not a mechanism by which viruses cause cancer?
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They produce defective interfering particles.
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Which of the following is not true regarding the human hepatitis D virusoid?
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Its genome is a circular, single-stranded RNA molecule. It needs a helper virus to infect host cells. It produces one protein called the delta antigen.
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Which of the following is not true of viroids
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Extracellular viroids have a lipid bilayer envelope.
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Viroids are of economic significance because they cause disease in
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plants
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Viroids are:
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short infectious single stranded RNAs that can infect some plants.
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Prions are of significance because they cause infections of
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domestic animals and humans.
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Which of the following diseases is (are) caused by prions?
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Scrapie. Mad cow disease. Kuru and Creutzfeldt-Jakob Disease.
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Prions consist of proteins and have no apparent nucleic acid genome. T/F
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True
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Available evidence is consistent with the proposal that prion diseases are caused by infectious proteins. T/F
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True
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The mechanism of pathogenesis by prions may involve a conformational change in the prion protein (PrP) to an abnormal form. T/F
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True
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There are no known human diseases that have been linked to prions. T/F
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False
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