HBS-Unit 3 Test – Flashcards
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What body system deals with food?
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Digestive
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What body system deals with water?
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Urinary
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What body system deals with oxygen?
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Respiratory
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Rule of 3's
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3 min without air
3 days without water
3 weeks without food
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Definition of enzyme
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A protein serving as a catalyst, a chemical agent that changes the rate of reaction without being consumed by the reaction.
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Definition of substrate
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A substance acted upon by an enzyme.
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Importance of enzymes
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Enzymes are the spark that starts the essential chemical reactions our bodies need to live. They are necessary for digesting food, for stimulating the brain,m for providing cellular energy, and for repairing all tissues, organs, and cells
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How enzymes are named
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Enzyme names end in -ase and are often named after the substrate. For example, the enzyme that catalyzes the hydrolysis of sucrose is sucrase
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Where enzymes are made
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Ribosomes, pancreas, saliva, stomach, intestinal cells
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Basics of the lock and key model of enzyme action
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The lock is the enzyme and the key is the substrate. Only the correctly sized key fits into the key hole (active site) of the lock. Smaller keys, larger keys, or incorrectly positioned teeth on keys (incorrectly shaped or sized substrate molecules) don't fit into the lock. Only the correctly shaped key opens a particular lock
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Basics of the induced fit model of enzyme action
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Assumes that the substrate plays a role in determining the final shape of the enzyme and that the enzyme is partially flexible. This explains why certain compounds can bind to the enzyme but don't react because the enzyme has been distorted too much. Other molecules may be too small to induce the proper alignment and therefore cannot react. Only the proper substrate is capable of inducing the proper alignment at the active site.
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Active sites
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The specific region of the enzyme which combines with the substrate
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Describe the function of co-enzymes
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Carry out catalysis. They bind to the active site and help with the reaction
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Identify 3 different co-enzymes
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Vitamins B-2, B-3, and C
FMN
NAD
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Identify foods that are good sources of these co-enymes
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Beef, fish (trout), broccoli
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How does catalase work and what does it break down?
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Catalase is an enzyme in the liver that breaks down harmful hydrogen peroxide into oxygen and water. When this reaction occurs, oxygen gas bubbles escape and create foam.
H2O2-->H20 + O2
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How does temperature affect enzymes?
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Higher, faster reaction
Drops if gets too hot (45 degrees Celsius)
More energy
Human body temp: 37 degrees Celsius
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How does concentration affect enzymes?
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As the concentration increases, the reaction increases
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How does substrate concentration affect enzymes?
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As concentration increases, the reaction increases
Drops once there isn't enough enzyme to have reaction occur (around 1%)
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How does pH affect enzymes?
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As pH increases, reaction increases until it gets past 7.2
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Lipase
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Lipase is a protein (enzyme) released by the pancreas into the small intestine. It helps the body absorb fat
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Amylase
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An amylase is an enzyme that catalyses the hydrolysis of starch into sugars. Amylase is present in the saliva of humans and some other mammals, where it begins the chemical process of digestion.
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Pepsin
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Pepsin is an enzyme that breaks down proteins into smaller peptides (that is, a protease). It is produced in the stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food.
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Trypsin
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a digestive enzyme that breaks down proteins in the small intestine. It is secreted by the pancreas
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Maltase
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an enzyme, present in saliva and pancreatic juice, that catalyzes the breakdown of maltose and similar sugars to form glucose
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What is the oral cavity and what does it contain?
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The oral cavity is the first part of the digestive tract and it contains the mouth along with the organs in the mouth.
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What is the function of the salivary glands?
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The salivary glands produce saliva, which keeps the mouth and other parts of the digestive system moist.
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What is the function of the tongue?
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The tongue aids in moving food in the mouth, chewing, and swallowing.
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What is a bolus?
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A bolus is small rounded mass of a substance. Chewed food at the moment of swallowing is an example of bolus.
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Where are the soft and hard palate located and what are their functions?
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The soft and hard palate are located at the roof of the mouth. The hard palate is at the front, and the soft palate is at the back. The hard palate holds the root of the teeth. The soft palate pressed down for swallowing.
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What mechanical and chemical digestion occurs in the oral cavity?
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The mechanical digestion that occurs in the oral cavity is chewing. The chemical digestion occurring in the oral cavity is the enzymes in saliva commencing the degrading of food.
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What mechanisms are in place to make sure food does not "go down the wrong tube" and into the windpipe?
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A flap of skin, known as the epiglottis, separates the esophagus from the trachea, thus preventing food from "going down the wrong tube".
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What is peristaltic movement and how does it function in the esophagus?
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Peristaltic movement is a type of muscle contraction and it functions in the esophagus by helping push food to it.
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Does any digestion of food occur in the esophagus?
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Yes, some digestion of food occurs in the esophagus.
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What are the primary functions of the stomach?
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The primary functions of the stomach are to break down food after feeding and to extract the nutrients necessary to the body.
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What is chyme and how does the stomach mix this material?
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Chyme is the pulpy acidic fluid that passes from the stomach to the small intestine. The stomach mixes this material by combining food, enzymes, and gastric juices.
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What role does the stomach play in decontaminating the incoming food matter?
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The stomach contains a lot of acids which which help break down food matter and kill bacteria.
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What cells in the stomach function to form enzymes and acids?
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Parietal cells in the stomach function to form enzymes and acids.
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Why doesn't gastric juice digest the inside of the stomach?
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The stomach is made to be strong enough to handle the gastric juices, thus protecting itself from being digested.
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What are sphincters and how are they related to the stomach?
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Sphincters are the openings into and out of the stomach. They open and close when needed to either allow food into the stomach or to allow digested food out of the stomach.
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What mechanical and chemical digestion occurs in the stomach?
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A type of mechanical digestion that occurs in the stomach is churning. A type of chemical digestion that occurs in the stomach is the role of gastric acid.
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What are the three sections of the small intestine and what role does each section play in digestion or absorption?
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The three sections of the small intestine are the duodenum, jejunum, and ileum. The duodenum receives partly-digested food, acid, and bile. The jejunum and ileum break down food fully.
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What is the pH within the small intestine and how is this pH maintained?
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The pH of within the small intestine is 6. This pH is maintained through bicarbonate ions.
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Where do bile and pancreatic enzymes enter the small intestine?
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Bile and pancreatic enzymes enter the small intestine through the duodenum.
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How does food move through the intestines?
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The pathway of food through the intestines is:
duodenum ? jejunum ? ileum ? cecum ? colon ? rectum
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What enzymes act inside the small intestine and what are the functions of these enzymes?
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The enzymes that act inside the small intestine are amylase, protease, and lipase. Amylase acts on starch and breaks it down into small carbohydrate molecules. Protease acts on proteins and breaks them down into amino acids. Lipase breaks down dietary fats into smaller molecules called fatty acids and glycerol.
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What is the function of the large intestine in relation to digestion?
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In relation to digestion, the large intestine absorbs water and salts. It also stores waste material until they're thrown out of the body.
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What are the three sections of the large intestine and what roles does each play in digestion or absorption?
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The three sections of the large intestine are the cecum, colon, and rectum. The cecum takes digested liquid from the ileum and passes it on to the colon. The colon is the principal place for water reabsorption and absorbs salts when needed. The rectum is where leftover waste sits until it is ready to be emptied through the anus.
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How does the large intestine help maintain a water balance in the body?
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The large intestine helps the body digest and remove water from the remains of food (feces) after which it will go through the rectum.
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What are the size and the location of the pancreas?
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The pancreas is about six inches long and is located in the abdomen.
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What are the different functions of the pancreas, and how is the pancreas directly related to digestion?
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The pancreas has an endocrine function (releases juices directly in bloodstream) and exocrine function (releases juices straight into ducts). Enzymes that are secreted by the pancreas are sent to the small intestine for further break down of the food.
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How does the pancreas connect to the rest of the digestive system?
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The pancreas lies beneath the stomach. It connects the rest of the digestive system through the small intestine and the duodenum.
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What enzymes are produced by the pancreas and what are their functions?
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The functions of the enzymes is to help down fats, carbohydrates, and proteins.
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How is insulin related to the digestive system?
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Insulin is released in the pancreas from a result in high blood sugar levels.
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What is the size of the liver and where is it located?
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The liver is located in the upper right portion in the abdominal cavity. It weighs about three pounds.
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How does the liver function in relation to digestion?
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The livers main function with the digestive system is to process the nutrients absorbed from the small intestine.
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What are other functions of the liver in the body?
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The liver is an organ that secretes hormones and chemicals due to it producing bile. It detoxifies blood from harmful substances, stores simple sugar glucose, breaks down hemoglobin, destroys old red blood cells and converts stored sugar into usable sugar when the body's glucose level falls below normal.
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What is the relationship between the liver and the gallbladder?
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The relationship between the liver and gallbladder is their structure and location. The gallbladder is located just underneath the liver.
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What is the function of bile and where does it enter the digestive tract?
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Bile aids in the digestion of lipids.
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Where is energy located in the ATP molecule?
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The bonds between each of the phosphates
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How is ADP generated?
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When a phosphate group is taken off from ATP
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Basal metabolic rate (BMR)
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The rate at which heat is given off by an organism at complete rest.
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Body mass index (BMI)
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A measure of body fat that is the ratio of the weight of the body in kilograms to the square of its height in meters.
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Why may BMI not be accurate?
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BMI (body mass index), which is based on the height and weight of a person, is an inaccurate measure of body fat content and does not take into account muscle mass, bone density, overall body composition, and racial and sex differences
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Discuss at least two health risks faced by people with a BMI above 25.
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heart disease, high blood pressure, stroke, Type 2 diabetes, high cholesterol, metabolic syndrome, cancer, osteoarthritis, sleep apnea, breathing problems, gallstones, reproductive problems.
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Discuss at least two health risks faced by people with a BMI below 20.
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inhibited growth and development, fragile bones, weakened immune system, anemia (low iron levels in blood), fertility issues, hair loss.
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Describe how being overweight affects at least three other body systems.
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Being overweight affects your cardiovascular system. Being overweight can also affect your respiratory system. If you have sleep apnea as a result of being overweight, your body is not always getting the oxygen it needs, which is what causes you to wake up often and not get a good night's sleep. Being overweight increases your risk for colon and gallbladder cancers (both parts of the digestive system).
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Describe how being underweight affects at least three other body systems.
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Being underweight can affect your skeletal system. Not getting enough nutrients can make your body calcium deficient, which can lead to osteoporosis (loss in bone density). It can also affect your immune system because your body does not have the nutrients it needs to fight off disease or infection. It can also affect the reproductive system by causing women or men to become infertile.
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Gas exchange that occurs between the alveoli and the capillaries in the lungs
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As you breathe in, oxygen goes to the alveoli and gets diffused into the bloodstream. Then, carbon dioxide comes from the heart, is diffused into the alveoli, and is discarded when we breathe out, or exhale. As you breathe in, the diaphragm contracts, and relaxes when you breathe out.
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Spirometer
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An instrument for measuring the air entering and leaving the lungs.
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Minute Volume
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The volume of air breathed in one minute without conscious effort: MV = TV x (breaths/minute).
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Note that Melissa's exam indicates a pulse ox value of 91%. What is this value and how can it be used to monitor overall health?
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The pulse oximeter (pulse ox) measures the saturation of oxygen in the bloodstream. In other words, out of the total amount of oxygen that could be absorbed in the bloodstream (100%), how much oxygen actually is absorbed? For a person with a healthy respiratory system, the pulse ox level should be 94 - 99%. Anything under 90% is dangerous for a prolonged period of time. Between 90% and 94% could indicate some sort of long-term respiratory issue. So Melissa's level indicates that something could be wrong with her respiratory system.
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Asthma
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Hypertensive airways, inflammation, irritated, red, and swollen airways, tightening (constricted) muscles, and increase in mucus
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Triggers for an asthma attack
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strenuous exercise, cold air, dust mites, pollen, tobacco smoke, mold, and pet dander
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bid, BID
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twice a day
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Prn, PRN
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as needed
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q
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every
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qh
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every hour
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q4h
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every 4 hours
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qd
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every day
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ac
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before meals
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pc
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after meals
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cap, caps
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capsule
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i, ii, iii, or iiii
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The number of doses (1, 2, 3, or 4)
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mg
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milligrams
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ml
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milliliters
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tab
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tablet
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tbsp
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tablespoon (15 ml)
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tsp
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teaspoon (5 ml)
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po, PO
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by mouth
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IV
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intravenous
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FEV1
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also called Tiffeneau-Pinelli index, is a calculated ratio used in the diagnosis of obstructive and restrictive lung disease. It represents the proportion of a person's vital capacity that they are able to expire in the first second of forced expiration.
Normal range: 80-150
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Enteral routes for drugs (through the GI tract)
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oral, sublingual (under tongue and dissolve), buccal (between gums and cheek)
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Parenteral routes for drugs (via injection)
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intradermal (in dermis), subcutaneous (below dermis), intramuscular, intravenous injection (IV) (veins)
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Other routes (not including enteral or parenteral) for drugs
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transdermal (via skin preparations), ophthalmic (eye), otic (ears), nasal, inhalation, vaginal, rectal
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Accolate (zafirlukast)
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CONTROL
generic
twice a day
by mouth
after meals
10 mg
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Albuterol sulfate
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RESCUE
chemical
every 4-6 hours as needed
1.25 mg for every 3 ml
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Difference between green, yellow, and red zones in an asthma action plan
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Green: 80%-100% of normal peak flow
Yellow: 50%-80% of normal peak flow
Red: Less than 50% of normal peak flow
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Antidiuretic Hormone (ADH) (what is it?) and explain how alcohol affects it
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Hormone produced by the neurosecretory cells in the hypothalamus that stimulates water reabsorption from kidney tubule cells into the blood and vasoconstriction of arterioles.
Allows water to move from the ducts to the capillaries
Alcohol decreases the amount of ADH being produced
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Aldosterone
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A mineralcortocoid produced by the adrenal cortex that promotes sodium and water reabsorption by the kidneys and potassium excretion in urine.
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What hormones are produced by the kidney and what function do they serve?
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-Vitamin D: stimulates uptake of calcium from food, maintenance of healthy bones, regulates response of immune system to infection
-Erythropoietin: stimulates production of mature red blood cells by acting on bone marrow
-Renin: controls blood pressure
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Describe the role of at least two other organs or structures that help the body deal with an influx of alcohol
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Eliminated through excretion of alcohol in breath, urine, sweat, feces, and saliva
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Diuretics are often prescribed to treat high blood pressure. Given the name of the class of drug, how do you think diuretics affect the kidney, the fluid and electrolyte balance in the body and overall blood pressure?
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Diuretics work on the kidneys to cause them to retain more sodium. This also causes water to diffuse into the tubules from the bloodstream. This removal of excess sodium and water from the bloodstream can help to reduce blood pressure. (If the sodium is not removed, then the next time a person drinks water, the pressure will go up again, because the water will diffuse into the area of lowest concentration, which is the bloodstream.)
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Explain how drinking too much water can throw off the electrolyte balance in your blood. How does this imbalance specifically affect the nervous system and the muscular system?
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Drinking too much water can dilute the electrolytes in the bloodstream. This can be a very serious condition as well, because electrolytes like sodium and potassium are essential for the transmission of a nervous signal from one end of a neuron to the other end. Without a sufficient concentration of sodium and potassium in the bloodstream, a neuron could not conduct its signal.
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Explain how a shortage of water affects the health of your cells.
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A shortage of water will cause your cells to be hypotonic. If there is not enough water outside the cells (because you are sweating or have been drinking and are losing all your water through your urine), then water will move from the area of higher concentration (inside the cell) to an area of lower concentration (outside the cell). This process is called osmosis. This osmosis will occur until the cells are isotonic with the surrounding environment, meaning that the concentration of water inside and outside is the same. But too little water in the cells can be a very bad thing, and if a cell is severely dehydrated, it will die.
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Kidney
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One of a pair of vertebrate organs situated in the body cavity near the spinal column that excrete waste products of metabolism, in humans are bean-shaped organs about 4½ inches (11½ centimeters) long lying behind the peritoneum in a mass of fatty tissue, and consist chiefly of nephrons by which urine is secreted, collected, and discharged into the pelvis of the kidney whence it is conveyed by the ureter to the bladder.
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Ureter
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A duct leading from the kidney to the urinary bladder.
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Bladder
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The pouch where urine is stored prior to elimination.
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Urethra
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A tube that releases urine from the body near the vagina in females or through the penis in males; also serves in males as the exit tube for the reproductive system.
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Importance of transitional epithelium in the bladder
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As more urine builds up in the bladder, the epithelium expands, but once it's released/excreted, the epithelium contracts back to normal size
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Which part of the nephron is in the cortex and which part is in the medulla?
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The cortex contains the renal capsule, proximal, and distal convoluted tubules. The medulla and medullary rays contain the loops of Henle and collecting ducts.