Fostamatinib C23H26FN6O9P structure

C23H26FN6O9P structure
Molecular Formula C23H26FN6O9P
Average mass 580.459 Da
Density 1.5±0.1 g/cm3
Boiling Point 814.2±75.0 °C at 760 mmHg
Flash Point 446.2±37.1 °C
Molar Refractivity 137.9±0.3 cm3
Polarizability 54.7±0.5 10-24cm3
Surface Tension 68.8±3.0 dyne/cm
Molar Volume 387.8±3.0 cm3
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-13038A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13038A
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. MedChem Express
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.; IC50 Value: 41 nM [1]; Target: Syk; in vitro: R788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. MedChem Express HY-13038A
      Syk MedChem Express HY-13038A

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 814.2±75.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.1 mmHg at 25°C
Enthalpy of Vaporization: 124.1±3.0 kJ/mol
Flash Point: 446.2±37.1 °C
Index of Refraction: 1.629
Molar Refractivity: 137.9±0.3 cm3
#H bond acceptors: 15
#H bond donors: 4
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 2.12
ACD/LogD (pH 5.5): -2.18
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.10
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 197 Å2
Polarizability: 54.7±0.5 10-24cm3
Surface Tension: 68.8±3.0 dyne/cm
Molar Volume: 387.8±3.0 cm3

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