Fostamatinib C23H26FN6O9P structure

Flashcard maker : Jessica Forbes

Molecular FormulaC23H26FN6O9P
Average mass580.459 Da
Density1.5┬▒0.1 g/cm3
Boiling Point814.2┬▒75.0 °C at 760 mmHg
Flash Point446.2┬▒37.1 °C
Molar Refractivity137.9┬▒0.3 cm3
Polarizability54.7┬▒0.5 10-24cm3
Surface Tension68.8┬▒3.0 dyne/cm
Molar Volume387.8┬▒3.0 cm3
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Experimental Physico-chemical Properties
    • Experimental Solubility:

      DMSO 250 mg/mL; Water 48 mg/mL MedChem Express HY-13038A
  • Miscellaneous
    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-13038A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13038A
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. MedChem Express
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.; IC50 Value: 41 nM [1]; Target: Syk; in vitro: R788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. MedChem Express HY-13038A
      Syk MedChem Express HY-13038A

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.5┬▒0.1 g/cm3
Boiling Point: 814.2┬▒75.0 °C at 760 mmHg
Vapour Pressure: 0.0┬▒3.1 mmHg at 25°C
Enthalpy of Vaporization: 124.1┬▒3.0 kJ/mol
Flash Point: 446.2┬▒37.1 °C
Index of Refraction: 1.629
Molar Refractivity: 137.9┬▒0.3 cm3
#H bond acceptors: 15
#H bond donors: 4
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 2.12
ACD/LogD (pH 5.5): -2.18
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.10
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 197 Å2
Polarizability: 54.7┬▒0.5 10-24cm3
Surface Tension: 68.8┬▒3.0 dyne/cm
Molar Volume: 387.8┬▒3.0 cm3

Click to predict properties on the Chemicalize site

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