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Aristo chemistry Essay Example
3075 words 6 pages

Detecting the presence of chemical species Action of heating solid sample strongly Chapter 64 Separation and purification methods Centrifugation Sublimation Partition equilibrium of a solute between two immiscible solvents Two-dimensional thin-layer chromatography 2 3 6 Chapter 65 Quantitative methods of analysis Detection of end point in acid-alkali titration 8 Chapter 66 Instrumental analytical methods More […]

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Chemistry Partition Coefficient Water
Lab Report Partition Coefficient
284 words 1 page

Purpose: The purpose of this particular lab was to demonstrate the difference in separation of Benzoic acid in water and Dichloromethane. Also the difference in separation of Benzoic acid in bicarbonate and Dichloromethane. By calculating the partition coefficient for each of these separations, it became clear the differences in the separation of the aqueous and […]

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Acid Partition Coefficient Solubility

Popular Questions About Partition Coefficient

What is partition coefficient of a drug?
The partition coefficient is the measure of the lipophilicity of a drug and an indication of its ability to cross the cell membrane. It is defined as the ratio between un-ionized drug distributed between the organic and aqueous layers at equilibrium.
What does a partition coefficient of 1 mean?
Most commonly, one of the solvents is water, while the second is hydrophobic, such as 1-octanol. Hence the partition coefficient measures how hydrophilic ("water-loving") or hydrophobic ("water-fearing") a chemical substance is. Partition coefficients are useful in estimating the distribution of drugs within the body.
Is a high partition coefficient better?
permeability of cell membranes. … unit of measure called the partition coefficient. The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.
Why is the partition coefficient important?
Partition coefficients are useful in estimating the distribution of drugs within the body, as it gives a measure of a solute's hydrophobicity and a proxy for its membrane permeability.