DEXTROSE 50% IN WATER (D50W)(T22)

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DEXTROSE 50% IN WATER (D50W)(T22) Brand Name:
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(25 gm of Dextrose in a 50 ml solution).
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DEXTROSE 50% IN WATER (D50W)(T22) Classification:
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Carbohydrate.
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DEXTROSE 50% IN WATER (D50W)(T22) Mechanism of Action:
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Provides immediate source of glucose for cellular metabolism.
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DEXTROSE 50% IN WATER (D50W)(T22) Indications:
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ALOC due to documented or suspected hypoglycemia.
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DEXTROSE 50% IN WATER (D50W)(T22) Contraindications:
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1. There are no absolute contraindications to the IV administration of dextrose 50% in the emergency setting. 2. Relative contraindication: Use with caution in patients with increasing Intracranial pressure as the added glucose may worsen the cerebral edema.
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DEXTROSE 50% IN WATER (D50W)(T22) Side Effects:
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1. Patients may complain of warmth, pain or burning at the injection site. 2. Dextrose can cause severe neurologic symptoms (Wernicke’s encephalopathy or Korsakoff’s psychosis) if patient is thiamine deficient.
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DEXTROSE 50% IN WATER (D50W)(T22) Precautions:
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1. Aspirate prior to administration and after every 10-15 ml to ensure IV patency (medication will cause necrosis). 2. Cannulate largest vein possible and run IV wide open prior to and after administration. 3. Relative contraindication: Use with caution in patients with increasing intracranial pressure as the added glucose may worsen the cerebral edema or potentiate cellular necrosis in hemorrhagic stroke.
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DEXTROSE 50% IN WATER (D50W)(T22) Interactions:
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None.
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DEXTROSE 50% IN WATER (D50W)(T22) Routes of Administration:
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IV, IO.
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DEXTROSE 50% IN WATER (D50W)(T22) Onset and Duration of Actions:
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Onset will be 30-60 seconds but duration depends upon degree and cause of hypoglycemia.
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DEXTROSE 50% IN WATER (D50W)(T22) Dosages:
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ADULT: 25 gm (50 ml solution preload) IVP/IO May repeat once in 5 minutes PEDIATRIC: Birth – 1 month: 5-10 ml/kg slow IVP of a 10% solution. May repeat once in10 minutes. 1 month+-2 years: 2 ml/kg slow IVP/IO of a 25% solution. May repeat once in 5 minutes. Over 2 years: 1 ml/kg slow IVP/IO of a 50% solution (same solution as for the adult) May repeat once in 5 minutes.
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DEXTROSE 50% IN WATER (D50W)(T22) Notes:
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Do not exceed a 12.5% concentration in neonates.

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