Dermatology: Drug, drug class/moa, indication, dose/frequency, AE – Flashcards

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Retin-A, Retin-A Micro, Avita, Tretin-X (Tretinoin)
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Topical vitamin A analog Indication: Acne, psoriasis Apply once at bedtime irritation, erythema, peeling, skin discoloration category x
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Differin (Adapalene)
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Topical vitamin A analog Indication: Acne Apply once daily erythema, dryness
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Tazorac (Tazarotene)
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Prodrug, Vitamin A analog Indication: Acne, psoriasis Apply once daily erythema, pruritis, stinging, burning, do not use on >20% bsa
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Ery-Gel, Erycette, Akne-Mycin, Benzamycin (erythromycin, topical)
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macrolide antibiotic Indication: Acne Apply twice daily erythema, desquamation, dryness, pruritis
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Clindagel, Cleocin-T, Benza-Clin, Acanya (clindamycin, topical)
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Lincosamide antibiotic Indication: acne apply twice daily dryness, burning, itching, erythema
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Azelex (Azelaic Acid)
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Topical antibiotic Indication: acne apply twice daily burning, stinging, tingling, pruritis
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Amnesteem, Claravis, Sotret (Isotretinoin)
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Retinoid Indication: severe nodular/conglobata acne Dose: 0.5-1 mg/kg/day, divided BID Dry mucosa (mouth, nose, eyes) Cheilitis with desquamation ↑ TG's - FLP baseline, 2 & 4 weeks, then monthly Alopecia Muscle/joint pain Blood dyscrasias - CBC baseline, 2 & 4 weeks, then monthly Hepatitis - LFT's baseline, 2 & 4 weeks, then monthly Depression - monitor s/sx depression & suicide Photosensitivity Teratogenicity - negative Hcg monthly; iPLEDGE program
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Dovonex, Calcitrene, Sorilux (Calcipotriene)
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Vitamin D Analogue Indication: psoriasis applied 1 to 2 times/day skin irritation, burning, stinging, contact dermatitis, can cause hypercalcemia if systemically absorbed
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Vectical (Calcitriol)
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Vitamin D Analogue Indication: psoriasis applied 2 times daily, NTE 200 gm per week skin "discomfort," pruritis
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Drithocreme, Dritho-Scalp, Psoriatec (Anthralin)
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anthracene derivative Indication: psoriasis apply for 15 minutes nightly then remove irritation, inflammation, staining of skin (temporarily) and clothing
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Soriatane (Acitretin)
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MOA: not well understood Indication: psoriasis 25 to 50 mg daily orally dry skin, pruritis, hepatotoxicity, ↑ TG's Contraindicated in females who are pregnant or plan pregnancy within 3 years following drug discontinuation (category X) Females should not ingest EtOH during or for 2 months after treatment
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Remicade (Infliximab)
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monoclonal antibody directed against TNF-α Indication: psoriasis 5mg/kg by slow IV infusion at weeks 0, 2, and 6 then every 8 weeks headaches, fever, chills, fatigue, diarrhea, abdominal pain
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Enbrel (etanercept)
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binds free- and membrane-bound TNF-α Indication: psoriasis 50 mg subcutaneous twice per week injection site reaction, N/V, abdominal pain, cough, rhinitis, headache, rash, respiratory tract infection
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Stelara (Ustekinumab)
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monoclonal antibody; human interleukin 12 and 23 antagonist Indication: psoriasis 100kg: 90mg SC initially, at week 4, then Q 12 weeks nasopharyngitis, URI, HA, fatigue, Reversible posterior leukenocephalopathy syndrome (RPLS), cv risk?
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Protopic (Tacrolimus, topical)
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Calcineurin inhibitors: inhibit T-cell activation Indication: atopic dermatitis 0.1% applied BID - mod-severe AD in adults 0.03% applied BID - mod-severe AD in kids 2 y/o + pruritis, burning, photosensitivity Black Box Warning: Controversial; warns of possible link between use and cancer
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Elidel (Pimecrolimus, topical)
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Calcineurin inhibitors: inhibit T-cell activation Indication: atopic dermatitis 1% applied BID in kids 2 y/o + pruritis, burning, photosensitivity Black Box Warning: Controversial; warns of possible link between use and cancer
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