Dermatology: Drug, drug class/moa, indication, dose/frequency, AE – Flashcards

Topical vitamin A analog Indication: Acne, psoriasis Apply once at bedtime irritation, erythema, peeling, skin discoloration category x

Topical vitamin A analog Indication: Acne Apply once daily erythema, dryness

Prodrug, Vitamin A analog Indication: Acne, psoriasis Apply once daily erythema, pruritis, stinging, burning, do not use on >20% bsa

macrolide antibiotic Indication: Acne Apply twice daily erythema, desquamation, dryness, pruritis

Lincosamide antibiotic Indication: acne apply twice daily dryness, burning, itching, erythema

Topical antibiotic Indication: acne apply twice daily burning, stinging, tingling, pruritis

Retinoid Indication: severe nodular/conglobata acne Dose: 0.5-1 mg/kg/day, divided BID Dry mucosa (mouth, nose, eyes) Cheilitis with desquamation ↑ TG's - FLP baseline, 2 & 4 weeks, then monthly Alopecia Muscle/joint pain Blood dyscrasias - CBC baseline, 2 & 4 weeks, then monthly Hepatitis - LFT's baseline, 2 & 4 weeks, then monthly Depression - monitor s/sx depression & suicide Photosensitivity Teratogenicity - negative Hcg monthly; iPLEDGE program

Vitamin D Analogue Indication: psoriasis applied 1 to 2 times/day skin irritation, burning, stinging, contact dermatitis, can cause hypercalcemia if systemically absorbed

Vitamin D Analogue Indication: psoriasis applied 2 times daily, NTE 200 gm per week skin "discomfort," pruritis

anthracene derivative Indication: psoriasis apply for 15 minutes nightly then remove irritation, inflammation, staining of skin (temporarily) and clothing

MOA: not well understood Indication: psoriasis 25 to 50 mg daily orally dry skin, pruritis, hepatotoxicity, ↑ TG's Contraindicated in females who are pregnant or plan pregnancy within 3 years following drug discontinuation (category X) Females should not ingest EtOH during or for 2 months after treatment

monoclonal antibody directed against TNF-α Indication: psoriasis 5mg/kg by slow IV infusion at weeks 0, 2, and 6 then every 8 weeks headaches, fever, chills, fatigue, diarrhea, abdominal pain

binds free- and membrane-bound TNF-α Indication: psoriasis 50 mg subcutaneous twice per week injection site reaction, N/V, abdominal pain, cough, rhinitis, headache, rash, respiratory tract infection

monoclonal antibody; human interleukin 12 and 23 antagonist Indication: psoriasis 100kg: 90mg SC initially, at week 4, then Q 12 weeks nasopharyngitis, URI, HA, fatigue, Reversible posterior leukenocephalopathy syndrome (RPLS), cv risk?

Calcineurin inhibitors: inhibit T-cell activation Indication: atopic dermatitis 0.1% applied BID - mod-severe AD in adults 0.03% applied BID - mod-severe AD in kids 2 y/o + pruritis, burning, photosensitivity Black Box Warning: Controversial; warns of possible link between use and cancer

Calcineurin inhibitors: inhibit T-cell activation Indication: atopic dermatitis 1% applied BID in kids 2 y/o + pruritis, burning, photosensitivity Black Box Warning: Controversial; warns of possible link between use and cancer