Copanlisib C23H28N8O4 structure

Flashcard maker : Jazzlyn Sampson

Molecular FormulaC23H28N8O4
Average mass480.520 Da
Density1.5±0.1 g/cm3
Boiling Point
Flash Point
Molar Refractivity125.7±0.5 cm3
Polarizability49.8±0.5 10-24cm3
Surface Tension64.0±7.0 dyne/cm
Molar Volume317.6±7.0 cm3
  • Experimental data
  • Predicted – ACD/Labs
  • Predicted – ChemAxon
  • Experimental Physico-chemical Properties
    • Experimental Solubility:

      10 mM in DMSO MedChem Express http://www.medchemexpress.com/vd3-d6.html, HY-15346
  • Miscellaneous
    • Bio Activity:

      BAY 80-6946(Copanlisib) is a potent and highly selective reversible PI3K inhibitor for PI3K?/? with IC50 of 0.469 nM/3.72 nM.; IC50 value: 0.469/3.72 nM(PI3K?/?) [1]; Target: PI3K?/?; in vitro: BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. MedChem Express HY-15346
      PI3K MedChem Express HY-15346
      PI3K/Akt/mTOR MedChem Express HY-15346
      PI3K/Akt/mTOR; MedChem Express HY-15346

Predicted data is generated using the ACD/Labs Percepta Platform – PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.722
Molar Refractivity: 125.7±0.5 cm3
#H bond acceptors: 12
#H bond donors: 3
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 1
ACD/LogP: -1.00
ACD/LogD (pH 5.5): -2.26
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -0.84
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 4.58
Polar Surface Area: 140 Å2
Polarizability: 49.8±0.5 10-24cm3
Surface Tension: 64.0±7.0 dyne/cm
Molar Volume: 317.6±7.0 cm3

Click to predict properties on the Chemicalize site

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