Chapter 3/pharmacology – Flashcards
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Allergic reaction
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acquired hyperresponse of body defenses to a foreign substance (allergen)
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Anaphylaxis
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acute allergic response to an antigen that results in severe hypotension and may lead to life-threatening shock if untreated
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Apothecary system
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older system of measurement that uses drams;rarely used
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ASAP order
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as soon as possible order that should be available for administration to the patient within 30 minutes of the written order
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Astringent effect
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drops or spray used to shrink swollen mucous membranes, or to loosen secretion and facilitate drainage
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Buccal route
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administration of a table or capsule by placing it in the oral cavity between the gum and the cheek
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Compliance
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taking a medication in the manner prescribed by the health care provider, or, in case of OTC drugs, following instructions on label
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Enteral route
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administration of drugs orally, and through nasogastric or gastrostomy tubes
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Enteric coated
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referring to tablets that have a hard, waxy coating designed to dissolve in the alkaline environment of the small intestine
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Five rights of drug administration
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principles that offer simple and practical guidance for nurses to use during drug preparation, delivery and administration
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Household system
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older system of measurement that uses teaspoons, tablespoons, and cupts
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Intradermal (ID)
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medication administered into the dermis layer of the skin
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Intramuscular (IM)
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delivery of medication into specific muscles
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Intravenous (IV)
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administration of medications and fluids directly into the bloodstream
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Metric system of measurement
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most common system of drug measurement that uses grams and liters
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Parenteral route
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dispensation of medication via a needle into the skin layers
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PRN order
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medication is administered as required by the patient's condition
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Routine orders
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order not written as STAT, ASAP, NOW, or PRN
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Single order
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medication that is to be given only once, and at a specific time, such as a preoperative order
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Standing order
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order written in advance of a situation that is to be carried out under specific cirumstances
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STAT order
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any medication that is need immediately and is to be given only once
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Subcutaneous
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medication delivered beneath the skin
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Sublingual route
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administration of medication by placing in under the tongue and allowing it to dissolve slowly
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Sustained release
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tablets or capsules designed to dissolve slowly over an extended time
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Three checks of drug administration
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in conjunction with the five rights, these ascertain patient safety and druf effectiveness
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The ____ route means the nurse will administer the drug to the patient by mouth, under the tongue, or into the rectum.
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enteral
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When the nurse places a drug directly onto the skin or associated membranes, this is referred to as the ______ route.
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topical
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The traditional ______ _______ of drug delivery form the operational basis for the safe delivery of medications.
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five rights
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Drugs swallowed or chewed or slowly dissolved in the mouth are referred to as _____ medications.
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oral
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________ administration involved plaocing drugs under the tongue.
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sublingual
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_______ and ________ are examples of rectal administration methods.
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suppositories, enemas
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The most common method of drug delivery is the ____ route.
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oral
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Drugs are injected directly into the muscle in the _________ route.
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intramuscular
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One popular method for delivering drugs across the skin at a slow steady rate is the _______ patch.
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transdermal
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________, ________ and ______ type drug delivery methods are useful in treating respiratory and reproductive ailments.
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...
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enteral
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rectal, oral, sublingual
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parenteral
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intravenous (IV), intramuscular (IM), subcutaneous (SC or SQ), intradermal
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topical
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transmucosal, transdermal
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define dissolution
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the process of dissolving solid drugs
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What is a standard order?
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prn
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What type of patient would be appropriate for rectal administration
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unconscious patient, patient with nausea or vomiting, infant who cannot swallow pills
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What is a major advantage of IV drug administration?
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a precise concentration of drug can be administered into the blood stream
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What is a disadvantage of subcutaneous drug administration?
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pain, swelling or infection may occur if proper precautions are not taken
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It rapid onset is critical which route would the nurse choose?
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intravenous
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What administration method would the nurse use for TB test with purified protein derivative (PPD)
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intradermal
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Implants are generally administered by which drug administration method?
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subcutaneous
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What intravenous drug administration might be used to instill adjunct medications, such as antibiotics and analgesics over a short period of time?
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intermittent infusion
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How are IV infusions administered?
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by way of a syringe and needle
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Whatis the deepest layer of the skin?
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dermis
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What is the most common type of drug formulation for eye and ear medication?
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drops
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Prior to administration of a medication through a gastrostomy tube, the nurse takes what action?
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aspirate feeding and check for residual volume
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A client has an allergac reaction to a newly prescribed medication. The nurse places the highest priority on what action?
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communicate the allergic response to the physician and the pharmacist
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The order reads "Lasix 40 mg IV STAT, what action should the nurse take?
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administer the medication within 5 minutes of the order
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The nurse determine the client needs an antipyretic medication. The nurse should check in which area of the MAR for this order?
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PRN orders ( orders that are administrated on an as needed basis are found in the PRN)
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A nasal spray is ordered for a client. The nurse knows that this medication contains an astringent effect, which will?
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shrink mucous membranes
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Toxic Epidermal Necrolysis (TEN)
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severe and deadly drug-induced allergic reaction, skin sloughing, 30% or more, associated with some anticonvulsants, antibiotics and some OTC, ex. advil & motrin
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Stevens-Johnson Syndrome (SJS)
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prompted by same drugs as TEN, begins within 1 to 14 days, signaled by nonspecific respiratory infection, chills, fever, malaise, blisterlike lesions follow in a few days, skin sloughing 10%
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Name five rights of drug .
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right patient, right medication, right dose, right route of administration, right time of delivery
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Name three checks of drug administration.
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1. checking drug with MAR or medication information system when removing it from drawer, refrigeration or controlled substance locker 2. checking the drug when preparing it, pouring it, taking it out of the unit-dose container, or connecting IV tubing to the bag 3. checking the drug before administering it to the patient
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Compliance
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taking a medication in the manner prescribed by the health care provider
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What is the primary role of a nurse in medication administration?
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ensure medications are administered and delivered in a safe manner
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Before administering drugs by the enteral route, the nurse should evaluate which of the following?
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ability of the patient to swallow
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What medications would not be administered through a nasogastric tube?
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entertic-coated tablets, sustained-release tablets, IV medications
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ac
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before meals
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ad lib
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as desired/as directed
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bid
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twice per day
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AM
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morning
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cap
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capsule
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gtt
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drop
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h or hr
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hour
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IM
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intramuscular
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IV
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intravenous
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no
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number
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pc
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after meals;after eating
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PO
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by mouth
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PM
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afternoon
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PRN
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when needed/necessary
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qid
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four times per day
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q2h
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every 2 hours(even or when first given)
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q4h
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every 4 hours (even)
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q6h
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every 6 hours (even)
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q8h
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every 8 hours (even)
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q12h
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every 12 hours
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Rx
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take
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STAT
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immediately;at once
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tab
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tablet
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tid
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three times per day
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1mL (metric) convert to apothecary & household
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15-16 minims (apothecary) 15-16 drops (household)
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4-5 mL (metric) convert to apothecary & household
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1 fluid dram (apothecary) 1 teaspoon or 60 drops (household)
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15-16 mL (metric) convert to apothecary & household
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4 fluid drams (apothecary) 1 tablespoon or 3-4 teaspoons (household)
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30-32mL (metric) convert to apothecary & household
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8 fluid drams or 1 fluid ounce (apothecary) 2 tablespoons (household)
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240-250 mL (metric) convert to apothecary & household
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8 fluid ounces (1/2) pint (apothecary) 1 glass or cup (household)
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500 mL (metric) convert to apothecary & household
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1 pint (apothecary) 2 glasses or 2 cups (household)
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1 L (metric) convert to apothecary & household
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32 fluid ounces or 1 quart (apothecary) 4 glasses or 4 cups or 1 quart (household)
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1 mg (metric) convert to apothecary
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1/60 grain (apothecary)
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60-64 mg (metric) convert to apothecary
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1 grain (apothecary)
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300-325 mg (metric) convert to apothecary
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5 grains (apothecary)
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1 g (metric) convert to apothecary
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15-16 grains (apothecary)
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1 kg (metric) convert to household
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2.2 pounds (household)
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administration guidelines for a tablet
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assess patient is alert, has ability to swallow place capsules in medication cup if liquid, shake bottle,measure into medication cup offer glass of water, milk or juice if not contrtraindicted remain with patient until swallowed
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administration guidelines for sublingual
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assess that patient is alert and has ability to hold medication under tongue place under tongue instruct patient, do not chew, swallow or move tablet with tongue remain with patient until dissolved offer glass of water
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administration guidelines for buccal
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assess that patient is alert and has ability to hold medication between gums and cheek place tablet instruct patient do not chew, allow to dissolve completely remain with patient until dissolved offer glass of water
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administration guidelines for nasogastric and gastrostomy
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administer liquid forms when possible to avoid clogging tube if solid, crush finely into powder and mix thoroughly with at least 30 mL of warm water until dissolved assess and verify tube placement turn of feeding if applicable aspirate stomach contents and mesure residual volume, if greater than 100mL for adult, check agency policy return residual via gravity and flush with water pour medication into syring barrel and allow to flow into the tube by gravity, give each medication separately, flushing between with water keep head of bed elevated for 1 hour to prevent aspiration reestablish continual feeding, as scheduled, keep head of bed elevated 45 degree to prevent aspiration
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nasogastric tube (NG)
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soft flexible tube inserted by way of the nasopharynx with the tip lying in the stomach
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gastrostomy tube (G)
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tube is surgically placed directly into the patient's stomach
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What types of drug cannot be crushed and administered through NG or G tubes?
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sustained-release drugs
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dermatologic preparations
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drugs applied to the skin, creams, lotions, gels, powders and sprays
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instillation and irrigations
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drugs applied into body cavities or orifices, eyes ears, nose, urinary bladder, rectum and vagina
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inhalations
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drugs applied to the respiratory tract by inhalers, nebulizers, or positive-pressure breathing apparatuses
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transdermal drug administration
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read mfg. guidlines apply gloves cleanse area if using ointment apply amount on paper that accompanies medication tube press to clean dry, hairless skin rotate sites to prevent irritation label patch with date, time and initials
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ophthalmic drug administration
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instuct patient to lie supine or sit with head slightly tilted back pull lower lid down gently to expose conjunctival sac, creating pocket ask patient to look upward hold eyedropper 1/4-1/8 inch above eye, do not hold dropper over eye (may cause blink) instill into eye, if applying ointment apply thin line along inner edge of lower lid margin, instruct patient to close eye gently, apply gentle pressure to the nasolacrimal duct for 1-2 minutes , wipe excess with tissue, replace dropper
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otic drug administration
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instruct patient to lie on side or to sit with head tilted so that affected ear is facing up if necessary clean pinna of ear and meatus with a clean washcloth to prevent discharge from being washed into ear canal hold dropper 1/4" above ear canal, install drops into the side of ear canal, avoid placing drops directly on the tympanic membrane apply intermittent pressure to the tragus of the ear 3-4 times instruct patient to remain on side for 10 minutes, it cotton ball ordered, presoak with medication and insert into outermost part of ear canal wipe any solution that may have dripped
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nasal drops administration
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ask patient to blow nose instruct patient to open and breath through mouth, measure correct volume into dropper, hold tip of dropper above nostril without touching the nose with dropper, direct solution toward the midline of the superior concha of the ethmoid bone- not the base of the nasal cavity, ask patient to stay in position for 5 minutes, discard any remaining solution that is in dropper
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vaginal drug administration
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instruct patient to assume a supine position with knees bent and separated place water soluble lubricant into medicine cup apply gloves, open suppository and lubricate rounded end expose vaginal orifice by separating labia insert about 8-10cm along the posterior wall of vagina or as far as it will pass if using cream, jelly or foam insert application 5cm along posterior wall of vaginal and slowly push the plunger remove applicator and place on a paper towel ask patient to lower legs and remain in supine or side lying position for 5-10 minutes
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intradermal route administration
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prepare medication in a tuberculin or 1 mL syringe with preattached 26-27 guage 3/8 to 5/8 neede, apply gloves, cleanse injection site, with thumb and index finger spread skin taunt, insert needle with bevel facing upward at angle of 10-15 degrees, advance needle until entire bevel is under skin;do not aspirate, slowly inject medication to for small wheal or bleb, withdraw needle quickly and pat site with sterile 2 X 2 gauze, instruct patient not to rub or scratch area, draw circle around perimeter of injection site, read in 48 to 72 hours
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subcutaneous route
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prepare medication in a 1 to 3 mL syringe using a 23 to 25 guage, 1/2 to 5/8 needle, for heparin use 3/8 needle and 25-26 guage, choose side, check previous rotation sites, apply gloves and cleanse injection site, allow to dry, bunch skin between thumb and index finger spead taunt, insert needle at 45 to 90 angle dependeing on body size, 90 degree if obese, 45 degree if average weight, if patient very thin gather skin and insert at 90 degree angle, for nonheparin injections, aspirate by pulling back on plunger, if blood appears, withdraw needle, discard syringe and prepare new injection. for heparing do not aspirate ( can cause damage surrounding tissues and cause bruising)
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intramuscular route; ventrogluteal (different guidelines would apply to the dorsogluteal, vastus lateralis, and deltoid muscle sites)
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prepare medication, using a 20-23 gauge, 1 to 1.5" needle, apply gloves, cleanse ventrogluteal site, let dry,insert needle with smooth, dartlike movement, angle at 90 degree within V-shaped area, aspirate and observe for blood, if blood appears, discard syrings, inject slowly and with smooth even pressure, remove needle quickly, apply pressure with 2 X 2 gauze and massage vigourously to create warmth and promote absorption of the medication into the muscle
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intravenous route of drug administration
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to add to IV fluid container- verify order and compatibility of drug with IV fluid prepare medication in a 5 to 20 mL syringe, using a 1 to 1.5", 19-21 gauge needle, apply gloves, assess injection site for signs and symptoms of inflammation or extravasation, locate medication port on IV fluid container and cleanse with antiseptic swab, carefully insert needle or access device into port and inject medication, withdraw needle and missolution by rotating container end to end, hand container and check infusion rate
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When is deltoid site used for injections?
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well-developed teens and adults for volumes of medication not to exceed 1 mL, usually only used for small-volume vacines, ex; hepatitis B
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When is dorsogluteal site used for injection?
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adults and for children who have been walking for at least 6 months, nurse must avoid puncture or irritation of the sciatic nerve and blood vessels
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What is the vastus lateralis site used for injection?
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middle third of the muscle is the site of IM injections
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large-volume infusion administration
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IV administration for fluid mainteance, replacement or supplmentation
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intermittent infusion administration
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this is a small amount of IV solution that is arranged tandem with or piggybacked to the primary large-volume infusion, used to instill medications over a short period of time ex: antibiotics or analgesics
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IV bolus (push) administration
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this is a concentrated dose delivered directly to the circulation via syringe to administer single-dose medications
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What is the goal of studying pharmacology?
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to limit the number and severity of adverse drug events
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What are most common causes of med errors?
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incomplete patient information unavailable drug information miscommunication of drug orders: illegible handwritten orders lack of appropriate labeling environmental factors: distractions during the preparation of administration of drugs
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First-pass metabolism
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medication absorbed in the stomach and intestine first travel to the liver where they may be inactivated before they ever reach the target organs
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Pharmacokinetics
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study of drug movement or motion throughout the body
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Processes of Pharmacokinetics:
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absorption, distribution, metabolism, excretion