Chapter 23. The Urinary system – Flashcards

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Normal urine from a healthy person should not contain
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Glucose
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Which organ system does not excrete waste?
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The Cardiovascular system
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Excretion systems
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*Respiratory system: CO2, small amounts of other gases, & water. *Integumentary system: Water, inorganic salts, lactic acid, urea in sweat. *Digestive system: Water, salts, CO2, lipids, bile pigments, cholesterol, & other metabolic waste. *Urinary system: Many metabolic wastes, toxins, drugs, hormones, salts, H+ & water.
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Kidneys functions
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Filter blood plasma, excrete toxic wastes. Regulate blood volume, pressure, and osmolarity. Regulate electrolytes and acid-base balance. Secrete erythropoietin production of RBCs. Help regulate calcium levels by participating in calcitriol synthesis. Clear hormones from blood. Detoxify free radicals. In starvation, they synthesize glucose from amino acids.
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Urinary system organs
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Kidney, Ureter, Urinary bladder and urethra
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Nitrogenous wastes and sources
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*NH2 from protein forms ammonia which liver converts to urea. *Uric acid & creatinine produced by catabolism of nucleic acids & creatine phosphate.
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Location and appearance of kidney
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Against posterior abdominal wall. Right kidney slightly lower than Left because of right lobe Liver.
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External features
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Medial surface has a slit, the hilium, that admits renal nerves, blood vessels, lymphatics and ureter.
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Internal features
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Renal fascia: fibrous tissue that binds the kidney to abdominal wall. Perirenal fat capsule: layer of adipose tissue that hold kidney in place. Fibrous capsule: encloses the kidney to protect it from trauma and infection.
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Flow of blood through kidneys
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Afferent arterioles-->Glomerular capillaries--->Efferent arterioles---> Peritubular capillaries and/or vasa recta.
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Flow of fluid through renal tubules
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glomerular capsule - PCT - nephron loop - DCT - collecting duct - papillary duct - minor calyx - major calyx - renal pelvis - ureter - urinary bladder - urethra.
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Nerve supply
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Cortical radiate vein and arcuate vein
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Cellular structure of glomerulus
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Ball of capillaries enclosed in a sphere called glomerular capsule. Blood leaves it by way of efferent arteriole.
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Forces in filtration
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Blood hydrostatic pressure (BHP), Colloid osmotic pressure (COP) & Capsular pressure (CP).
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Nephron loop in filtration
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reabsorbs 25% of Na+, K+ and Cl− in filtrate. NaCl remains in the tissue fluid of renal medulla. Water cannot follow since thick segment is impermeable.
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PCT
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reabsorbs about 65% of glomerular filtrate, removes some substances from blood, and secretes them into tubular fluid for disposal in urine.
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Tubular reabsorption(from tubular fluid to blood)
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*Nephron reabsorbs about half of urea in tubular fluid. *PCT reabsorbs uric acid. *Creatinine is not reabsorbed, passed in urine.
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Tubular secretion(from blood into tubular fluid)
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By PCT and nephron. *hydrogen and bicarbonate ions helps regulate pH of body fluids. *Urea, uric acid, bile acids, ammonia, and a little creatinine. *drugs and contaminants. Examples include: morphine, penicillin, and aspirin.
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Nephron regulates water excretion
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Generation of salinity gradient allows CD to concentrate urine, also helped by electrolyte reabsorption.
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Maintenance of osmotic gradient in renal medulla
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By the countercurrent multiplier. Recaptures NaCI and returns it to renal medulla.
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Functional anatomy of ureters, urinary bladder, and urethra
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Ureter transport urine to bladder, the bladder stores the urine until full, the urethra is the exit by which urine leaves the body.
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Properties and composition of urine
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Yellow color due to urochrome pigment from breakdown of Hb. Odor, bacteria degrade urea to ammonia. 95% water, 5% solutes.
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Abnormal solutes in urine
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glucose, free hemoglobin, albumin, ketones, bile pigments
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Normal solutes in urine
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urea, NaCl, KCl, creatinine, uric acid, phosphates, sulfates, traces of calcium, magnesium, and sometimes bicarbonate, urochrome, and a trace of bilirubin
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Variations in urine
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Pyuria: pus in the urine. Hematuria: blood in urine due to urinary tract infection, trauma, or kidney stones
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Blood plasma is filtered in the
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renal corpuscle
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The __________ muscle is located in the urinary bladder.
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Destrusor
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To meet the definition of polyuria, the minimum daily output of urine is
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2.0 L
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The fenestrated endothelium of the capillary has pores small enough to exclude blood cells from the filtrate.
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True
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Which of the following would reduce the glomerular filtration rate?
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Vasoconstriction of the afferent arteriole
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The most toxic of our metabolic wastes are nitrogenous wastes.
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True
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Aldosterone acts on the
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distal convoluted tubule
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In life threatening starvation, the kidneys synthesize glucose by _
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deaminating amino acids
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In a healthy kidney, very little __________ is filtered by the glomerulus.
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Protein
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Micturition is another term for __________.
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The elimination of urine
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In response to a drop in overall blood pressure, __________ stimulates constriction of the glomerular inlet and even greater constriction of the outlet.
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Angiotensin II
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The urine is most likely to be hypotonic when the __________.
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body's water volume is high
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Hypocalcemia stimulates
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Secretion of parathyroid hormone
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In the nephron, the fluid that immediately precedes urine is known as __________.
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tubular fluid
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Glucose and amino acids are reabsorbed from the glomerular filtrate by the __________.
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Proximal convoluted tubule (PCT)
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The transition from an afferent arteriole to an efferent arteriole occurs in the __________
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Glomerulus
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Which of the following is not reabsorbed by the proximal convoluted tubule?
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Hydrogen ions
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Which of the following are primarily responsible for maintaining the salinity gradient of the renal medulla?
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Juxtamedullary nephrons
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The __________ is not an organ of the urinary system.
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liver
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The mechanism of stabilizing the GFR based on the tendency of smooth muscle to contract when stretched is known as __________.
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the myogenic mechanism
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Renin hydrolyzes angiotensinogen, which is released from the _________, to form angiotensin I.
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Liver
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Parathyroid hormone increases phosphate excretion by the PCT as well as promotes synthesis of calcitriol.
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True
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Ethyl (drinking) alcohol stimulates the secretion of ADH, thereby reducing reabsorption by the collecting duct.
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False
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Which of the following is a direct result of antidiuretic hormone?
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Decreased urine volume
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The average person has approximately __________ nephrons per kidney.
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1.2 million
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Which of the following form the inner layer of the glomerular capsule and wrap around the capillaries of the glomerulus?
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Podocytes
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A byproduct of protein catabolism, __________ constitutes approximately one-half of all nitrogenous waste.
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Urea
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The pigment responsible for the color of urine is called __________.
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Urochrome
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Which of the following is NOT a function of the kidneys?
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They release waste into the bloodstream
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Which of the following does NOT contribute to water conservation?
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Diuretics
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