Chapter 12: Diabetes, Cardiovascular Disease, and Cancer – Flashcards

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What is chronic disease?
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A disease that comes on gradually and lasts a long time; many chronic diseases can be managed but resist and complete cure.
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Are Cardiovascular disease and diabetes chronic diseases?
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yes
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How are CVD and diabetes managed?
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By a combination of lifestyle changes and medications focused on reducing the patient's cardio metabolic risk; that is, factors such as obesity, elevated blood pressure, and others that associated with theses two chronic diseases.
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What is the five year survival rate for all cancers?
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68%
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How many deaths does chronic disease cause?
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7 out of every 10 deaths in the U.S. each year. They are responsible for more than 54% of all deaths in the U.S. each year.
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When do many of the deaths due to chronic disease occur?
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Prematurely, that is at an earlier age.
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What are some effects of smoking?
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It can causes inflammation, reduced circulation, damage to blood vessels, genetic changes, and other problems that in turn are factors in diabetes, CVD and cancer.
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How are diabetes, CVD and cancer related?
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The functions of the chemicals, cells, and tissues of our bodies are interrelated, and certain factors that initiate disease in one body organ or system can initiate disease in another.
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What are the four key behaviors most strongly associated with the onset of chronic disease?
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-poor nutrition(obesity increases the risk for the most common form of diabetes as well as CVD and certain cancers) -lack of physical activity -tobacco use(single most avoidable cause of disease, disability, and death in the U.S.) -excessive alcohol consumption
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At what age is diabetes most seen in?
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Adults over the age of 64. It is one of the most common serious illnesses in the U.S. More than 11% of Americans aged 20 or older have diabetes and another 35% are on their way to developing it.
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What is diabetes mellitus?
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A group of diseases in which the body does not make or use insulin properly, resulting in elevated blood glucose. Covers a group of diseases characterized by high levels of sugar, or glucose in the blood. These high levels of blood glucose arise from problems with insulin, a hormone produced by the pancreas that is necessary for transportation of glucose into the body's cells.
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What occurs to people with diabetes after they eat?
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Some people with diabetes simply don't make enough insulin to clear enough glucose from the bloodstream. Others make enough insulin, but their body cells don't respond to it effectively. In either case, glucose builds up in the bloodstream, while the body's cells--unable to take in glucose--suffer from lack of nourishment.
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How does type 1 diabetes arise?
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It arises when the body's own immune system destroys the cells in the pancreas that make insulin
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When does type 1 diabetes usually appear?
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Usually appears in childhood or adolescence, and researchers are investigation the role of specific genes in its development as well as the possible role of external factors such as viruses.
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How is type 1 diabetes managed?
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People with it must monitor their blood glucose level throughout each day and take supplemental insulin. For this reason, type 1 diabetes is often know as insulin-dependent diabetes.
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Is there a cure for type 1 diabetes?
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There is no cure for type 1 diabetes, but the condition is the focus of intense research, including studies into the use of stem cell therapy to replace the pancreas insulin-making beta cells
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What is type 2 diabetes?
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A form of diabetes that usually begins later in life and arises when cells resist the effects of insulin.
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What was type 2 diabetes once known as?
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Adult-onset diabetes.
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What is the difference between type 1 and type 2 diabetes?
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With type 1 the cells of the pancreas stop making insulin, most cases of type 2 diabetes begin as insulin resistance. The pancreas makes normal amounts of insulin, but the body's cells don't respond to it properly, they resist its effects.
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Why do the body's cells resist the effects of insulin?
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One factor in this resistance is the interference due to an overabundance of fatty acids concentrated in fat cells. This explains why type 2 diabetes is linked not only to age but also to obesity.
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How does hyperglycemia occur?
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When the body's cells can't respond to insulin, they can't take up glucose, and it remains in the blood stream.
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How can the pancreas lose the ability to produce insulin?
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The resulting hyperglycemia signals the pancreas to produce more insulin to get more glucose into the cells. As the demand for insulin continues to rise, the cells of the pancreas begin to fatigue. With continued high demand over time, they can lose their ability to produce insulin, just as in type 1 diabetes.
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What is gestational diabetes?
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Develops in a women during pregnancy and affects up to 2-10% of pregnancy women. The condition usually disappears after childbirth, but researchers have learned that women who develop gestational diabetes have a 30%-60% chance of developing type 2 diabetes within the next 10-20 years.
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What is type 1.5 diabetes?
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It is a general term for several varieties of diabetes that blend aspects of type 1 and type 2. It is also called latent autoimmune diabetes of adults (LADA) type 1.5 is often revealed when blood tests show some immune system destruction of pancreatic beta cells but healthy insulin producing beta cells as well.
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What are some physical signs and symptoms of diabetes?
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Frequent urination, excessive thirst, hunger, tendency to tire easily, numbness or tingling in the hands and feet, in women a tendency to develop vaginal yeast infections.
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What is FBG?
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FBG, or fasting blood glucose test. Requires you to fast overnight. A technician then draws a blood sample, and the level of glucose in your blood is measured.
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Describe blood glucose levels.
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-a blood glucose level below 100 mg/dl is normal -a blood glucose level between 100 and 125 means that you have prediabetes -a blood glucose level of 126 mg/dl or higher indicates true diabetes
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What is prediabetes?
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A persistent state of blood glucose levels higher than normal, but not yet high enough to qualify as diabetes.
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What is the glycated hemoglobin test?
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Also known as the A1C test, it measures how much glucose is attached to the hemoglobin. An A1C level of 6.5% or higher on two separete occasions indicates that you have diabetes, whereas 5.7% to 6.4% indicates prediabetes.
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What are the long term effects of diabetes?
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damage to the blood vessels, kidneys filters are affected, severe gum disease. Diabetes also increases the risk of death from infection, several cancers and a variety of other disorders.
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How many years does diabetes shave off a person's life?
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6 years and it is the 7th leading cause of death in the U.S.
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What are some risk factors for type 2 diabetes?
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overweight, disproportionately large waist, diet, lack of exercise, chronic stress, genetic factors.
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What happens after age 50?
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Body cells become increasingly less responsive to the effects of insulin
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Clinical management of diabetes
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glucose monitoring, weight loss, oral medications, insulin therapy
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What is CVD?
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Cardiovascular disease, or CVD, is a group of disorders that includes hypertension, coronary heart disease, congestive heart failure, and stroke.
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What is the leading cause of adult morality in the U.S.?
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CVD and it is responsible for more than 3 in 10 deaths.
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What are arteries?
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Vessels that transport blood away from the heart, delivering oxygen rich blood to the body periphery and oxygen poor blood to the lungs.
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What are veins?
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Vessels that transport blood toward the heart, delivering oxygen poor blood from the body periphery or oxygen rich blood from the lungs.
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What is the myocardium?
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The heart's muscle tissue. The contractions of the myocardium keep blood moving, ensuring that it transports oxygen and nutrients to, and eliminates wastes from, every region of the body.
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What are the four chambers of the heart?
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The upper two chambers are the atria. Each atrium is connected by a valve to one of the corresponding lower ventricles. This division lets each side of the heart focus on a different task--either sending oxygen poor blood to the lungs for replenishment or pumping that re-oxygenated blood back out to the rest of the body.
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What are capillaries?
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The smallest blood vessels, delivering blood and nutrients to individual cells and picking up wastes.
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What is atherosclerosis?
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Condition characterized by narrowing of the arteries because of inflammation, scarring, and the buildup of fatty deposits.
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What is blood pressure?
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The force of the blood moving against the arterial walls.
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What is hypertension?
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It is a persistent state of elevated blood pressure. In addition it is also a risk factor for other forms of CVD, including coronary heart disease, congestive heart failure and stroke.
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Factors influencing blood pressure
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The level of your blood pressure is determined, in part, by the pumping actions of your heart.
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What is a systole?
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When your heart contracts, an action called systole, the pressure of the blood in your arteries momentarily increases. When it relaxes it is called diastole, your blood pressure drops.
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What is blood pressure affected by?
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Compliance, the ability to stretch and recoil--of your arteries.
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What can increase blood volume?
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Excessive glucose, sodium or other solutes in the blood.
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Signs and symptoms of hyper tension
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Most people with hypertension experience no symptoms. A very few people with dangerously advanced hypertension may experience headaches and dizziness.
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Long-term effects of hypertension
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left untreated, it can lead to the other forms of CVD. It can also cause vision loss and kidney disease and can reduce your ability to think clearly, remember and learn.
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How is blood pressure measured?
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It is measured using a stethoscope and a device called a sphygmomanometer. Readings are recorded in millimeters of mercury.
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Clinical managedment of hypertension
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- low sodium diet -water pills
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What is CHD?
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Coronary heart disease is a disease characterized by atherosclerosis of the arteries that feed the heart; angina; and reduced blood supply to the myocardium
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What happens when there is a large or total blockage of the coronary arteries?
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A myocardial infarction can be triggered, or a disruption in heart rhythm known as sudden cardiac arrest.
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What is angina pectoris?
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Chest pain due to coronary heart disease. It occurs when the heart's need for nutirents and oxygen exceeds what the coronary arteries provide. It signals that a person is at significant risk of a life-threatening cardiac event.
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Myocardial Infarction
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The more time that passes without treatment to restore blood flow, the greater the damage.
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Warning signs of MI
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Angina, discomfort in the chest or other parts of the upper body, shortness of breath, and sweating, nausea, or dizziness. Women are less likely to experience less specific forms of pain and discomfort.
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What happens when the heart is starved of blood?
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The nerve cells of the sinus node can also be affected, resulting in an irregularity of the heartbeat called an arrhythmia, in which the heart can beat too slowly, too quickly, or unevenly.
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What is bradycardia?
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A slow arrhythmia. A slow heart rate of less than 60 beats per min
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What is tachycardia?
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A fast arrhythmia. A fast heart rate--more than 100 beats per min. An especially dangerous type of tachycardia is fibrillation.
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What happens in fibrillation?
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An improper electrical signal causes either the atria or the ventricles to contract so quickly and unevenly that they quiver rather than pump, unable to move blood effectively.
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What happens with sudden cardiac arrest?
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The person's heart must be restarted within 6 min via electrical shock to prevent death. Even if the heart is restarted within 6 min, the patient may sustain irreversible brain damage from lack of oxygen to the brain.
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What is an EKG, or ECG?
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It measures the heart's electrical activity and is commonly used to detect arrhythmias as well as the restricted blood flow that causes angina. An ECG conducted with the patient resting provides a baseline measurement, or the test can be done while the patient is exercising.
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What does a stress test show?
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shows how the heart performs under increased physical demands.
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What is an echocardiogram?
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It may be done during the stress test to produce images of the heart using sound waves.
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What does asprin do?
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helps prevent blood clots and improves blood flow.
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How do nitroglyercin tablets work?
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people will take them by placing the tablets under their tounge or use a spray version. It dialates blood vessles.
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Management of sudden cardiac arrest
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The persons heart must be restarted with an AED. Automatic external defibrillator. It sends an electric shock to the heart and can restore a normal heartbeat.
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What is an implantable cardioverter defibirllator?
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It is similar to a pacemaker, but transmits stronger electric pulses to help prevent further dangerous arrhythmias.
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what is congestive heart failure?
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it is when the heart can no longer pump enough blood to meet the body's needs. As a result blood may pool, or become congested in other areas of the body, such as the lungs, the abdomen or the arms and legs.
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What is a stroke?
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Also called cerebrovascular accident, it is a medical emergency in which the blood supply to a part of the brain ceases.
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What is an ischemic stroke?
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Either a cerebral artery or one of the carotid arteries that run through the neck into the brain becomes blocked. All brain tissues normally served by the blocked artery become starved of oxygen and nutrients.
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What is an hemorrhagic stroke?
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The term hemorrhage, means uncontrolled bleeding. A weakened cerebral artery leaks or ruptures, spilling blood into brain tissue. The blood compresses and damages the brain cells in the area of the spill.
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What are the two most common causes of hemorrhagic strokes?
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-uncontrolled hypertension -aneurysm, a weak spot in an artery wall that may rupture.
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What is an transient ischemic attack?
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A temporary episode of strokelike sumptoms, idicative of high stroke risk.
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Long term effects of a stroke
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-paralysis -impaired speaking, swallowing and chewing -aphasia, a difficulty in understanding and expressing ideas in spoken or written words -loss of memory -pain
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Congenital heart disease
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effects include holes in the walls that divide the chambers of the heart, abnormal narrowing of the coronary arteries, and malformations of the arteries that connect the heart and lungs.
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Hypertrophic cardiomyopathy
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a genetic disorder resulting in a thick, stiffened muscle wall that cannot pump enough blood during rigorous activity.
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Rheumatic heart disease
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begins when a bacterial infection, caused by the same streptococcus bacterium that causes strep throat, flares into rheuamatic fever. Along with an electaed temp. the illness causes inflammation of connective tissues throughout the body
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What is dyslipidemia?
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Disorder characterized by abnormal levels of blood lipids, such as high LDL, cholesterol or low HDL cholesterol.
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What is metabolic syndrome?
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A set of 5 unhealthy physical and metabolic conditoins together linked to an increased risk for type 2 diabetes and other metabolic diseases.
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What is cardiometabolic risk?
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A cluster of nine modifiable factors that identify individuals at risk for type 2 diabetes and cardiovascular disease.
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What is cancer?
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A group of diseases marked by the uncontrollable multiplication of abnormal cells.
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What are carcinogens?
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substances known to trigger DNA mutations that can lead to cancer
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What happens if growth control genes are irreparably damaged?
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They become cancer causing oncogenes, issuing faulty orders for accelerated cell growth.
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what are the five types of cancer?
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-carcinomas -sarcomas -central nervous system cancers -lymphomas and myelomas -leukemias
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5 general signs of cancer
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unexplained weight loss, fever, fatigue, pain, skin changes
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What is the most deadliest form of skin cancer?
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Malignany melanomas
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