Biology 6 – Flashcards

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It acts by permanently modifying the active site.
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Which statement about the feedback inhibition of enzymes is not true?
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potential energy
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Water held behind a dam would best reflect ______.
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the part of the enzyme that binds with a substrate.
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An active site is
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constant.
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The first law of thermodynamics states that the total energy in the universe is
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True
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True or False: Temperature, pH, and ionic concentrations each play an important role in the proper functioning of enzymes.
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Energy
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What can never be created or destroyed?
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Catabolism
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The process of breaking glycogen down to glucose is an example of: ____.
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prevent the substrate from binding the enzyme's active site.
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Altering the three-dimensional structure of an enzyme might
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The reaction will yield energy and is spontaneous.
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What would you predict about a reaction that has a ΔG < 0?
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Energy
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The ability to promote change or do work.
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Kinetic Energy and Potential Energy
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Two forms of energy
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Kinetic Energy
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Associated with movement
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Potential Energy
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Due to structure or location (stored energy)
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Chemical Energy
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The energy in molecular bonds is a form of potential energy.
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Kinetic Energy
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Girl hits ball with a baseball bat
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Potential Energy
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Women shoots bowen arrow
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1st law of thermodynamics
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"Law of Conservation of Energy" Energy cannot be created or destroyed but can be transformed from one type to another.
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Entropy
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Degree of disorder. As this increases, less energy is available for organisms to use to promote change.
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True
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True or False: Change in free energy determines direction of chemical reactions
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Total energy
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Usable energy and unusable energy =
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Free Energy
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Amount of energy avaliable to do work
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Spontaneous Reactions
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Occur without input of additional energy. Not necessarily fast, can be slow.
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True
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True or False: If Delta G is negative, then process is exergonic and spontaneous.
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Exergonic, spontaneous, energy is released by reaction
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Delta G < 0 (negative free energy change)
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Exergonic
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Spontaneous =
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Endergonic, not spontaneous, requires addition of energy to drive reaction
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Delta G > 0 (positive free energy change)
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Endergonic
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Not spontaneous =
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-7.3 KCAL/MOLE
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Delta G =
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ATP
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Cellular Energy
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Endergonic
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Energy input
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Exergonic
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Energy release
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Exergonic
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The energy to synthesize ATP comes from chemical reactions that are..
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Catalyst
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An agent that speeds up the rate of chemical reaction without being consumed during reactin
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Enzymes
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Protein catalyst in living cells
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Ribozymes
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RNA molecules with catalyst properties
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Active site
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location where reactions takes place
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Substrates
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Reactants that bind to active site
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Enzyme-substrate complex
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Formed when enzyme and substrate bind
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Phophorylates or places a phosphat group on another molecule
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Any enzyme called a "kinase" is an enzyme that...
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Competitive and non-competitive
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2 types of reversible inhibitors
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Competitive Inhibitors
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Molecules bind to active site, inhibits ability of substrate to bind
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Non-Competitive Inhibitors
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Inhibitors binds to allosteric site, not active site.
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Feedback Inhibition
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Very common cellular mechanism. If the concentration of the final product becomes high, it will bind to enzyme 1 and cause a conformational change that inhibits the enzymes ability to convert the initial substrate into intermediate 1.
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Initial --> intermediate 1 ----> intermediate 2 ----> final product ----> back to enzyme 1.
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What is the Feedback pattern?
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Prosthetic Groups
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Small molecules permanently attached to the enzyme
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Cofactor
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Usually inorganic ion that temporarily binds to enzyme
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Environment
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Enzymes are affected by..
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Temperature and pH
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Most enzymes function maximally in a narrow-range of what..
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Proteins
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Enzymes are..
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Catabolic Pathways
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breakdown cellular components, exergonic
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Anabolic Pathways
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Synthesis cellular components, endergonic, must be coupled to exergonic reaction.
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Catabolic Reactions
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breakdown of reactants, used for recycling building blocks, used for energy to drive endergonic reactions.
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Substrate-level phosphorylation
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Enzyme directly transfers phosphate from one molecule to another molecule
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Reduction
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Addition of electrons; addition of electrons reduces the net charge of a molecule
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Oxidation
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Removal of electrons. Oxygen is frequently involved.
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Redox Reduction
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Important in the metabolism of small molecules. Electron removed from one molecule is added to another.
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Gene Regulation
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Turns genes on or off
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Cellular Regulation
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Cell-signaling pathways like hormones
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Biochemical Regulation
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Feedback inhibition is what regulation?
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Each energy transfer increases the disorder of a system
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According to the second law of thermodynamics?
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exergonic, and spontaneous
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Reactions that release free energy are
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lowering the activation energy necessary to initiate the reaction.
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Enzymes speed up reactions by
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pH, temperature, and cofactors
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Which of the following factors may alter the function of an enzyme?
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providing the energy to drive endergonic reactions
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In Biological systems, ATP functions by
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Oxidized
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In a chemical reaction, NADH is converted to NAD+H. We would say that NADH has been?
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determining if the protein has a known ATP binding site
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Scientists are identifying proteins that use ATP as an energy source by
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raises the Km only.
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With regard to its effects on an enzyme-catalyzed reaction, a competitive inhibitor
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Degrade entire organelles and recycle their components.
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Autophagy provides a way for cells to
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