ALP Ch 19 – Flashcards

Which antibodies will be in the serum of a person with blood type B, Rh+? anti-A, anti-Rh anti-B, anti-Rh anti-B anti-A, anti-B, anti-Rh anti-A

When testing donated blood for compatibility you would find a person with O type blood will have anti-O antibodies in their plasma. has O type antigens on their red blood cells. will lack A and B red blood cell antigens. will lack plasma antibodies to A and B type antigens. lacks HLA and MHC antigens.

The symptoms of an immune complex reaction are due to antibodies against self. phagocytosis. complement activation. destruction of the antigen. cytokines.

Allergic contact dermatitis is due to IgM antibodies. IgE antibodies. activated macrophages. IgG antibodies. sensitized T cells.

In immune complex reaction shown in the figure, what is the small, circular/spherical structure labeled "a"? complement mast cell antibody neutrophil antigen

In immune complex reaction shown in the figure, what is the end result of the reaction? Complement is activated. IgG is directed against cell membrane antigens. Endothelial cells are damaged. Neutrophils are attracted and release enzymes. Antibodies destroy neutrophils.

All of the following lead to drug-induced thrombocytopenic purpura. Which occurs first? Purpura occurs on the skin. Drug binds to platelets. Antibodies against haptens are formed. Antibodies and complement react with platelets. Platelets are destroyed.

Which of the following statements about human embryonic stem cells is TRUE? They are typically obtained from the zygote stage of embryonic development. They are pluripotent. They are obtained in great numbers from umbilical cords of newborns. They are pluripotent and typically obtained from the blastocyst stage of embryonic development. They express no MHC II antigens.

All of the following regarding "immune privileged sites" are true EXCEPT they are rarely rejected. they do not have lymphatic vessels. they include any tissue transplanted from a pig. they include corneal and brain tissue. they explain how animals tolerate pregnancies without rejecting the fetus

A healthy immune system destroys cancer cells with CTLs and activated macrophages. tumor-specific antigens. activated macrophages. CTLs. CD+ T cells.

Which is true regarding Herceptin therapy? It neutralizes the growth factor EGF. It is an endotoxin that stimulates TNF by macrophages. It is used to treat some breast cancer patients. It is a vaccine to prevent the development of cancer. It acts as an immunotoxin to target and kill cancer cells

All of the following are reasons why an HIV vaccine has not been developed EXCEPT there is no known animal model of natural immunity for HIV infection. HIV has a high mutation rate so one vaccination would not be effective to treat the world-wide pandemic. small, inexpensive animals which could be used for HIV vaccine research are not available. use of a weakened virus would potentially transmit the infection. vaccines are not effective against viral infections.

Which of the following is the least likely vaccine against HIV? attenuated virus protein core subunit glycoprotein All of these vaccines are equally likely.

Chemotherapy to inhibit the progression of HIV infection utilizes all of the following mechanisms EXCEPT blockage of viral attachment. termination of viral DNA. destruction of viral ribosomes. prohibition of viral integration into host cell DNA. inhibition of viral proteases.

During the asymptomatic phase I of HIV disease, HIV infection is diagnosed by counting CD8+ T cells. detecting antibodies against HIV. counting CD4+ T cells. detecting viral RNA. the Western blot test.

All of the following are true of hypersensitivity EXCEPT it occurs in the presence of an antigen. it is synonymous with "allergy." it occurs when an individual is exposed to an allergen for the first time. it is due to an altered immune response. it requires previous exposure to an antigen.

In rheumatoid arthritis, IgM, IgG, and complement deposit in joints. This is an example of immunosuppression. immune complex autoimmunity. cell-mediated autoimmunity. cytotoxic autoimmunity. acquired immunodeficiency.

Graft-versus-host disease will most likely be a complication of a(n) Rh incompatibility between mother and fetus. corneal transplant. blood transfusion. bone marrow transplant. skin graft.

In the serological method for tissue typing, if human cells expressing HLA-I are mixed with anti-HLA-I, complement, and trypan blue, what would indicate the cells are HLA-I? Cells are damaged by complement. Trypan blue enters the cells. Anti-HLA antibodies bind to HLAs on lymphocytes. Enzyme is released from neutrophils. None of the answers are correct; the T cells are missing.

Which of the following best describes graft-versus-host disease? Immune cells attack transplanted tissue in a privileged site. A tissue transplant is rejected because the host's T cytotoxic cells are activated and kill the transplanted tissue. Immune cells in transplanted bone marrow attack the cells of the host. The cells of a host reject transplanted bone marrow.