AALAS intro to rats and rabbits – Flashcards
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what best describes the purpose of the federally mandated "alternatives search" in an animal protocol?
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A search for procedures that may replace the use of animals, reduce the number of animals used, or refine the methodology to minimize animal pain or distress
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An investigator's responsibilities towards the use of laboratory animals include assuring that staff are properly trained to:
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perform the animal procedures humanely. provide the necessary supportive care to the animals during a procedure. provide the necessary supportive care to the animals following a procedure.
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Why is pre-surgical fasting not necessary in rabbits?
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because they cannot vomit
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True or false: A rabbit with a moderately painful condition may appear and behave normally or have subtle changes in activity level.
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true
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true or false: Cardiac puncture is commonly permitted without anesthesia in rabbits
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false
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true or false: The most common sites for venipuncture are the ear vessels in rabbits
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true
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true or false: Long term anesthesia in rabbits is appropriately achieved by repeat dosages of a short-acting injectable anesthetic cocktail
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false
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true or false: Pentobarbital is a preferred agent for general anesthesia in rabbits
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false
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true or false: Long term anesthesia is appropriately achieved by gas anesthesia using a vaporizer
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true
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true or false: Antibiotics should be routinely administered to avoid wound infection in rabbits
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false
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true or false: During the procedure, rabbits should be monitored for anesthesia, body temperature, and cardiovascular and respiratory function.
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true
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true or false: Supportive care and monitoring can be discontinued when the rabbits have recovered from anesthesia.
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false
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According to the AVMA, which method is acceptable, when used by itself, for euthanasia of rabbits?
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Overdose of barbiturate formulation
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What information should be provided with the results of a database search for alternatives (4)
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The names of the databases used, the date of the search, the years of citations accessed, and the search strategy
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List 4 reasons a rabbit may develop gastrointestinal disorders
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Administration of certain antibiotics Transportation stress Eating a high-energy and low-fiber diet Proliferation of E. coli and Clostridium
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If an institution using rabbits for research receives federal funding, which two documents must that institution adhere to?
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Animal Welfare Regulations the Guide for the Care and Use of Laboratory Animals note: Rabbits are covered by the Animal Welfare Act and Regulations, and since the institution receives federal funding it must also follow the Guide.
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Which occupational health and safety concern is NOT relevant to performing research on rabbits?
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Risks for zoonotic diseases when working with healthy, specific pathogen free rabbits
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true or false: In selecting a site for immunization (in rabbits), areas of the animal's body that are used for grasping and handling should be avoided.
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true
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in regards to conduct of surgery on rabbits, what do the applicable federal mandates requireÉ
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aseptic technique for survival surgical procedures
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true or false: changing rat cages on an open bench is recommended.
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false
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true or false: it is recommended to house rats in filter-top cages
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true
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An investigator's responsibilities towards the use of laboratory animals include assuring that staff is properly trained for ...
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Provide the necessary supportive care to the animals following a procedure. Perform the animal procedures humanely. Provide the necessary supportive care to the animals during a procedure.
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Why is it difficult to assess pain or distress in rats?
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because rats do not always display signs of pain or distress
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What is the difference between inbred strains of rats and outbred stocks of rats?
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Rats in an inbred strain are more genetically similar to each other than rats in an outbred stock.
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why do rats require thermal support during anesthesia?
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because they lose body heat rapidly under anesthesia
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why is it not recommended to collect more than 10% of total blood volume at one time from a rat?
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because the rat could experience hypovolemic shock
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What should you be aware of due to a rat's high metabolic rate?
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they will rapidly eliminate drugs from their systems
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what should be monitored on a rat under anesthesia?
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body temo cardiovascular function respiratory function
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what is the only acceptable source of carbon dioxide?
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compressed CO2 gas in cylinders
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true or false: USDA law oversees research with laboratory strains of rats and mice.
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false
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true or false: shoebox cages have solid bottoms (so no perforations or holes) so that feces and urine CANNOT fall through
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true
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what may happen to rats who have just arrived at a facility
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they might undergo a quarantine period upon arrival (if required by the institution).
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What does the USDA say about Freunds complete adjuvant (FCA) immunization?
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it is a painful procedure
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what should you do when preparing a rat for surgery?
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firmly pinch the toe/foot to check for pain reflex BEFORE beginning surgery
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List the "acceptable" methods of euthanasia for rats
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barbiturate overdose dissociative agent combinations
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List the "acceptable with conditions" methods of euthanasia (according to AVMA)
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decapitation cervical dislocation inhalent anesthetic overdose
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true or false: cardiac puncture is most often allowed only as a terminal procedure.
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true
