Excoriated papules on the knees in dermatitis herpetiformis. Pathogenesis: deposition of IgA in papillary dermis - neutrophil recruitment and complement activation. Result of an immunologic response to chronic stimulation of the gut mucosa by gluten. HLA genes. Symptoms: papules, excoriations, intensly pruritic, burning, stinging Sites: Symmetrically distributed over extensor surfaces (elbows, knees, buttocks, shoulders) Ddx: Bullous pemphigoid, Erythema multiforme, Scabies Diagnosis: Skin biopsy. Serum IgA Treatment: Gluten free diet. Dapsone

Question

Excoriated papules on the knees in dermatitis herpetiformis. Pathogenesis: deposition of IgA in papillary dermis -> neutrophil recruitment and complement activation. Result of an immunologic response to chronic stimulation of the gut mucosa by gluten. HLA genes. Symptoms: papules, excoriations, intensly pruritic, burning, stinging Sites: Symmetrically distributed over extensor surfaces (elbows, knees, buttocks, shoulders) Ddx: Bullous pemphigoid, Erythema multiforme, Scabies Diagnosis: Skin biopsy. Serum IgA Treatment: Gluten free diet. Dapsone

Accepted Answer

There are intolerance to gluten products and complaints about a strong itch in patient’s history. More test answers on https://studyhippo.com/dermatology-pictures-2/

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