Recrystallization: Solvent and Solubility Essay Essay

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Recrystallization is the primary method for sublimating solid organic compounds through the differences in solubility at different temperatures. In this experiment. a suited dissolver was foremost determined. Acetanilide was produced by acetylation of aminobenzine with acetic anhydride. The petroleum phenylacetamide was dissolved in a dissolver in a warming H2O bath. The hot solution was filtered and the filtrate. cooled easy in an ice bath as crystals started organizing out. As the compound crystallizes from the solution. molecules of other compounds were excluded from the crystals to obtain pure phenylacetamide.


Recrystallization. referred to as the 2nd crystallisation. is a method in which two crystallisation procedures are performed. It is a procedure of fade outing the solid to be crystallized in a hot dissolver or solvent mixture and so chilling the solution easy. This technique can be used for big or little measures of stuffs. and is normally really effectual and efficient. The most of import facet of the recrystallization technique is the choice of the dissolver. A big figure of dissolvers are normally used for recrystallization of organic compounds. Among these are H2O. ethyl alcohol. ethyl ether. methyl alcohol. and hexane to call merely a few. A dissolver. which works attractively for one recrystallization. may be wholly unsuitable for purification of a different compound – the pick for recrystallization dissolver is made on a individual footing.

This is because of the fluctuation of solubility of different organic compounds in these dissolvers. A desirable recrystallizing dissolver would increase the solubility of the solute as the temperature rises. Aniline is a clear to somewhat yellow liquid with a characteristic olfactory property. It is somewhat soluble in H2O and mixes readily with most organic dissolvers. When exposed to visible radiation and air. it easy changes colour. It darkens because of atmospheric oxidization of an dross normally present in the benzine from which the aminobenzine was prepared. It is acetylated by warming a mixture of aminobenzine and acetic anhydride. organizing N-phenylacetamide. which is more normally known as phenylacetamide.

When a solid stuff is placed in a dissolver in which it has a low solubility. non much happens. A little fraction of the solid will fade out. but the remainder will non. They will non merely sit at that place. though. since equilibrium is in consequence. with solid molecules traveling into solution. and an tantamount figure of dissolved molecules reforming solid. but the same sum of undissolved stuff is seen. One manner to acquire the full solid to fade out is to heat the solution — most stuffs are more soluble in hot dissolver than in cold. Suppose it is subjected to heat at the boiling temperature of the dissolver ( the highest temperature which is practical ) . and the full solid goes into solution.

At some temperature. the concentration of solute will transcend its solubility. and the solid will get down to come back out of solution – it will crystallise. By the clip it returns to the initial temperature. about all of the original stuff has formed crystals. which can be removed from the dissolver by filtration. If the original solid contained little sums of drosss. the drosss would travel into solution every bit good. but since the drosss are present merely in little sums. they remain soluble when the temperature is lowered once more. Therefore. the crystals. which come out of solution. are more pure than the original sample. This is the kernel of purification by recrystallization ( Fig. 1 ) .

Figure 1: An impure solid in: ( A ) cold dissolver in which it has low solubility. ( B ) dissolver that has been warmed up to fade out all of the solid. and ( C ) dissolver that has cooled down to the original temperature. The crystallised solid is now pure. while the drosss remain in solution. The aims of the experiment were. ( a ) to synthesise phenylacetamide by the acetylation of aminobenzine. ( B ) to sublimate rough acetanilide merchandise by recrystallization. and ( degree Celsius ) to cipher the per centum output of pure phenylacetamide.


A. Compounds tested ( or Samples Used )
For the finding of recrystallizing dissolver. H2O. methyl alcohol. and hexane were tested. Aniline was allowed to respond with acetic anhydride to bring forth the phenylacetamide. Activated wood coal was added for stain.

B. Procedure
In taking the recrystallizing dissolver. a corn-grain sum of pure phenylacetamide was placed into each of three trial tubings. 1 milliliter of H2O. methyl alcohol. and hexane were added to each trial tubing. They were shaken. placed in a warm H2O bath ( 37 – 40o C ) for 1 – 5 proceedingss. and allowed to chill. Observations were recorded. For the petroleum phenylacetamide. 2mL of aminobenzine and 20mL of distilled H2O were assorted in an Erlenmeyer flask. 3mL of acetic anhydride was so easy added. Noting the alterations. the flask was cooled in an ice bath to rush the crystallisation. After chilling. the mixture was filtered. dried. and the petroleum phenylacetamide. weighed. In a beaker. the petroleum phenylacetamide was dissolved with 10mL of the recrystallizing dissolver ( H2O ) for every gm of the petroleum phenylacetamide and so subjected to heat in a H2O bath until all the solid atoms dissolved.

Figure 2: Fluted Filter Paper Folding

Removing the solution from the H2O bath. activated wood coal was so added to take the coloured drosss. After this. the solution was rapidly filtered while it was still hot utilizing a fluted filter paper. The residue was discarded and the filtrate was subjected to an ice bath for 5 – 10 proceedingss. It was so filtered to divide the crystals. When dried. the pure phenylacetamide was weighed.

The undermentioned set – ups were used:

Distilled Ice
Erlenmeyer flask

Figure 3: Ice Bath

Figure 4: Filtration of Hot Solution Using Fluted Fillter Paper


In choosing a suited dissolver. there is a set of features to see. First. the substance to be purified must hold a high solubility in the dissolver at its boiling point. and a significantly diminished solubility at lower temperatures ( limited merely by the freezing temperature of the dissolver ) . Second. the dissolver should fade out the drosss at all temperatures. Third. the dissolver must non respond with the substance to be purified. Fourth. a moderately volatile dissolver is preferred.

This consideration is dictated by the demand to finally take hints of dissolver from the crystals. and this is most easy accomplished by vaporization. either at room temperature or in an oven. Last. the dissolver should be cheap. non-toxic. and non-flammable. These are non perfectly required. but desirable features. which can assist to find the pick of a dissolver. Water is an ideal pick based on these standards. and is the preferable dissolver if it satisfies conditions 1-4.


From books:
Bayquen. A. et Al. ( 2009 ) . Laboratory Manual in Organic Chemistry. Quezon City: C & A ; E Publishing INC.

From the Internet:
chemicalland21. com/lifescience/phar/ACETANILIDE. htm 08/04/12
Bunnelle. W. et. Al. Recrystallization and Melting Point Determination Version 3. World Wide Web. chem. Missouri. edu/chem2050/Recrystallization % 20notes. physician 08/04/12

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