## Pharmacology

 IBW equation
 50 + (2.3 x Height in Inches over 60) 45 + (2.3 x Height in Inches over 60)
 ABW equation
 ABW=IBW + 0.4 (TBW – IBW)
 BSA m2 equation
 square root of ht(cm)x Wt(kg)/3,600
 what equation is used to calculate the CrCl ml/min?
 Cockcroft-Gault equation (140-age)(Wt Kg)/(72)(SrCr mg/dl)
 What are the normal values for CrCl in men and women
 Normal CrCl 97-137 ml/min males 88-128 ml/min femalesRenal dysfunction<60ml/min
 What is the normal creatinine levels in men and women
 Normal creatinine in men 0.8 to 1.3 mg/dl and in women: 0.6 to 1.0 mg/dl.
 What is the Volume of Distribution equation
 Vd L = dose/ C0 or Cl/K
 The elimination rate constant equation
 -K = ln(C1/C0)/t1-t0
 Half-life equation
 t ? hr= 0.693/KdOrt ? hr= (0.693)(Vd)/Cl
 What is the SS Steady State?
 Point at which, after multiple doses, amount of drug administered over a dosing interval equals amount of drug being eliminated over that same period
 Which body weight should you use to calculate CrCl
 IBW unless the person is OBESE, then use the adjusted body weight
 what’s the criteria for being obese
 What can you say about a drug that has a high Vd(L)
 the drug is lipophillic
 What can you say about a drug that has a low Vd(L)
 the drug is hydrophillic
 if you double the dose and the concentration doubles, what order drug is it?
 1st order
 describe 1st order drugs
 The fraction of the drug eliminated is constant
 Describe Zero order drugs
 The AMOUNT of Drug eliminated over time is constant
 What is CrCl and indicator of?
 of how well your kidneys are working
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